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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide
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Citation:
Mol Ther Nucleic Acids. 2023;102034 [Epub ahead of print]. doi:10.1016/j.omtn.2023.102034 Epub:
Yes Abstract:
Exon-skipping therapy mediated by antisense oligonucleotides is expected to provide a therapeutic option for Duchenne muscular... Delivery Method:
electroporation, intravenous (i.v.) Organism or Cell Type:
cell culture: RD, DMD patient derived myotubes, monkey primary cells; cynomolgus monkeys Citation Extract: Watanabe N, Tone Y, Nagata T, Masuda S, Saito T, Motohashi N, Takagaki K, Aoki Y, Takeda S. Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide. Mol Ther Nucleic Acids. 2023;102034 [Epub ahead of print]. doi:10.1016/j.omtn.2023.102034. |
Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit
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Citation:
eLife. 2023;12:RP91258. doi:10.7554/eLife.91258.1 Epub:
Not Epub Abstract:
Nitric oxide (NO) produced by nitric-oxide synthase (NOS) is a key regulator of animal physiology. Here we uncover a function... Delivery Method:
microinjection Organism or Cell Type:
Platynereis dumerilii (annelid) Citation Extract: Jokura K, Ueda N, Gühmann M, Yañez-Guerra LA, Słowiński P, Wedgwood KCA, Jékely G. Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit. eLife. 2023;12:RP91258. doi:10.7554/eLife.91258.1. |
Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression
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Citation:
Mol Ther Nucleic Acids. 2023 Sep 5;34:102024. doi: 10.1016/j.omtn.2023.09.001. eCollection 2023 Dec 12 Epub:
Not Epub Abstract:
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by a CTG repeat expansion in the DMPK gene that... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: DM1, mice Citation Extract: González-Martínez I, Cerro-Herreros E, Moreno N, García-Rey A, Espinosa-Espinosa J, Carrascosa-Sàez M, Piqueras-Losilla D, Arzumanov A, Seoane-Miraz D, Jad Y, Raz R, Wood MJ, Varela MA, Llamusí B, Artero R. Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. Mol Ther Nucleic Acids. 2023 Sep 5;34:102024. doi: 10.1016/j.omtn.2023.09.001. eCollection 2023 Dec 12. |
SASH1 contributes to glial cell migration in the early development of the central nervous system
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Citation:
Dev Biol. 2023 Sep 21:S0012-1606(23)00160-4. doi: 10.1016/j.ydbio.2023.09.006. Online ahead of print Epub:
Yes Abstract:
SAM and SH3 domain-containing 1 (SASH1), a member of the Sly protein family, is a tumor suppressor gene that has been studied... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhou Z, Wang P, Wang Q, Dong Z, Chen X, Zhuo R, Wu R, Liu Y, Yang L, Liu M. SASH1 contributes to glial cell migration in the early development of the central nervous system. Dev Biol. 2023 Sep 21:S0012-1606(23)00160-4. doi: 10.1016/j.ydbio.2023.09.006. Online ahead of print. |
Myosin1G promotes Nodal signaling to control Zebrafish Left-Right asymmetry
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.09.15.557992 Epub:
Not Epub Abstract:
Myosin1D (Myo1D) has recently emerged as a conserved regulator of animal LR asymmetry that governs the morphogenesis of the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kurup AJ, Bailet F, Furthauer M. Myosin1G promotes Nodal signaling to control Zebrafish Left-Right asymmetry. bioRxiv. 2023;[preprint] doi:10.1101/2023.09.15.557992. |
Discovery of seven hox genes in zebrafish thrombopoiesis
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Citation:
Blood Cells Mol Dis. 2023 Aug 30;104:102796. doi: 10.1016/j.bcmd.2023.102796. Online ahead of print Epub:
Not Epub Abstract:
Thrombopoiesis is the production of platelets from megakaryocytes in the bone marrow of mammals. In fish, thrombopoiesis... Delivery Method:
Vivo-Morpholino piggyback Organism or Cell Type:
zebrafish Citation Extract: Sundaramoorthi H, Fallatah W, Mary J, Jagadeeswaran P. Discovery of seven hox genes in zebrafish thrombopoiesis. Blood Cells Mol Dis. 2023 Aug 30;104:102796. doi: 10.1016/j.bcmd.2023.102796. Online ahead of print. |
Transposable elements drive the evolution of metazoan zinc finger genes
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Citation:
Genome Res. 2023 Sep 15. doi: 10.1101/gr.277966.123. Online ahead of print Epub:
Yes Abstract:
Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in metazoans. ZNF evolution is highly... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wells JN, Chang NC, McCormick J, Coleman C, Ramos N, Jin B, Feschotte C. Transposable elements drive the evolution of metazoan zinc finger genes. Genome Res. 2023 Sep 15. doi: 10.1101/gr.277966.123. Online ahead of print. |
Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation
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Citation:
Cells. 2023;12:2285. doi:10.3390/ cells12182285 Epub:
Not Epub Abstract:
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in maintaining normal homeostatic processes under the... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Gupta D, Orehek S, Turunen J, O’Donovan L, Gait MJ, El-Andaloussi S, Wood MJA. Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation. Cells. 2023;12:2285. doi:10.3390/ cells12182285. |
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain
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Citation:
Sci Rep. 2023;13, 15164. doi:10.1038/s41598-023-41240-z Epub:
Not Epub Abstract:
Inflammatory processes and mechanisms are of central importance in neurodegenerative diseases. In the brain, α-... Delivery Method:
intracerebroventricular (i.c.v.) infusion, stereotaxic brain injection Organism or Cell Type:
mice Citation Extract: Thomas R, Connolly KJ, Brekk OR, Hinrich AJ, Hastings ML, Isacson O, Hallett PJ. Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain. Sci Rep. 2023;13, 15164. doi:10.1038/s41598-023-41240-z. |
Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence
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Citation:
Elife. 2023 Sep 11;12:e58300. doi: 10.7554/eLife.58300 Epub:
Not Epub Abstract:
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic stem... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sahai-Hernandez P, Pouget C, Eyal S, Svoboda O, Chacon J, Grimm L, Gjøen T, Traver D. Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. Elife. 2023 Sep 11;12:e58300. doi: 10.7554/eLife.58300. |