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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12236 scientific papers returned from the database with the search filters currently being used below.

AMONDYS 45 (Casimersen), a Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations for Treatment in Duchenne Muscular Dystrophy.

Authors:
Vasterling ME, Maitski RJ, Davis BA, Barnes JE, Kelkar RA, Klapper RJ, Patel H, Ahmadzadeh S, Shekoohi S, Kaye AD, Varrassi G
Citation:
Cureus. 2023;15(12):e51237. doi:10.7759/cureus.51237
Epub:
Not Epub
Abstract:
AMONDYS 45 (casimersen) is an antisense oligonucleotide therapy used to treat Duchenne muscular dystrophy (DMD), a rare genetic...
Link:
https://www.cureus.com/articles/215610-amondys-45-casimersen-a-novel-antisense-phosphorodiamidate-morpholino-oligomer-clinical-considerations-for-treatment-in-duchenne-muscular-dystrophy#!/
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Vasterling ME, Maitski RJ, Davis BA, Barnes JE, Kelkar RA, Klapper RJ, Patel H, Ahmadzadeh S, Shekoohi S, Kaye AD, Varrassi G. AMONDYS 45 (Casimersen), a Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations for Treatment in Duchenne Muscular Dystrophy.. Cureus. 2023;15(12):e51237. doi:10.7759/cureus.51237.

Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouse

Authors:
Park E, Yun S-H, Jin H-S, Lee C-G, Lee S-H, Choi S-Y, Woo HG, Lim JE, Oh B, Jeong S-Y
Citation:
medRxiv. 2023;[preprint] doi:10.1101/2023.12.20.23300337
Epub:
Not Epub
Abstract:
BACKGROUNDS Osteopetrosis, a rare skeletal disease, is characterized by an increased bone mass resulting from impaired bone...
Link:
https://www.medrxiv.org/content/10.1101/2023.12.20.23300337v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Park E, Yun S-H, Jin H-S, Lee C-G, Lee S-H, Choi S-Y, Woo HG, Lim JE, Oh B, Jeong S-Y. Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouse. medRxiv. 2023;[preprint] doi:10.1101/2023.12.20.23300337.

Cost-effective strategies to knock down genes of interest in the retinas of adult Zebrafish

Authors:
Shihabeddin E, Santhanam A, O'Brien J
Citation:
Front Cell Neurosci. 2023;(17):[Epub] doi:10.3389/fncel.2023.1321337
Epub:
Not Epub
Abstract:
High throughput sequencing has generated an enormous amount of information about the genes expressed in various cell types and...
Link:
https://www.frontiersin.org/articles/10.3389/fncel.2023.1321337/abstract
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Shihabeddin E, Santhanam A, O'Brien J. Cost-effective strategies to knock down genes of interest in the retinas of adult Zebrafish. Front Cell Neurosci. 2023;(17):[Epub] doi:10.3389/fncel.2023.1321337.

TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning

Authors:
de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P
Citation:
bioRxiv. 2023:[preprint] doi:10.1101/2023.03.29.534583
Epub:
Not Epub
Abstract:
Patients with pathogenic variants in the TANGO2 gene suffer from severe and recurrent rhabdomyolysis (RM) episodes precipitated...
Link:
https://www.biorxiv.org/content/10.1101/2023.03.29.534583v3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P. TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning. bioRxiv. 2023:[preprint] doi:10.1101/2023.03.29.534583.

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

Authors:
Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell LJ, Boyd P, Palazzo I, Nagashima M, Silva NJ, Hitchcock PF, Qian J, Hyde DR, Blackshaw S
Citation:
Nat Commun. 2023 Dec 20;14(1):8477. doi: 10.1038/s41467-023-44142-w
Epub:
Not Epub
Abstract:
Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes through Müller glia (MG)...
Link:
https://www.nature.com/articles/s41467-023-44142-w
Delivery Method:
intravitreal injection & electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell LJ, Boyd P, Palazzo I, Nagashima M, Silva NJ, Hitchcock PF, Qian J, Hyde DR, Blackshaw S. Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina. Nat Commun. 2023 Dec 20;14(1):8477. doi: 10.1038/s41467-023-44142-w.

β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition

Authors:
Mizoguchi Y, Nakashima K, Sato A, Shindo A
Citation:
iScience. 2023 Nov 15;26(12):108469. doi: 10.1016/j.isci.2023.108469. eCollection 2023 Dec 15
Epub:
Not Epub
Abstract:
During morphogenesis, epithelial tissues reshape and expand to cover the body and organs. The molecular mechanisms of this...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(23)02546-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Mizoguchi Y, Nakashima K, Sato A, Shindo A. β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition. iScience. 2023 Nov 15;26(12):108469. doi: 10.1016/j.isci.2023.108469. eCollection 2023 Dec 15.

BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles

Authors:
Huang LC, McKeown CR, He HY, Ta AC, Cline HT
Citation:
Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2316542121. doi: 10.1073/pnas.2316542121. Epub 2024 Jan 10
Epub:
Not Epub
Abstract:
In developing Xenopus tadpoles, the optic tectum begins to receive patterned visual input while visuomotor circuits are still...
Link:
https://www.pnas.org/doi/10.1073/pnas.2316542121
Delivery Method:
electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Huang LC, McKeown CR, He HY, Ta AC, Cline HT. BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles. Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2316542121. doi: 10.1073/pnas.2316542121. Epub 2024 Jan 10.

SH2 domain protein E and ABL signaling regulate blood vessel size

Authors:
Schumacher JA, Wright ZA, Rufin Florat D, Anand SK, Dasyani M, Batta SPR, Laverde V, Ferrari K, Klimkaite L, Bredemeier NO, Gurung S, Koller GM, Aguera KN, Chadwick GP, Johnson RD, Davis GE, Sumanas S
Citation:
PLoS Genet. 2024 Jan 8;20(1):e1010851. doi: 10.1371/journal.pgen.1010851. Online ahead of print
Epub:
Not Epub
Abstract:
Blood vessels in different vascular beds vary in size, which is essential for their function and fluid flow along the vascular...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010851
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schumacher JA, Wright ZA, Rufin Florat D, Anand SK, Dasyani M, Batta SPR, Laverde V, Ferrari K, Klimkaite L, Bredemeier NO, Gurung S, Koller GM, Aguera KN, Chadwick GP, Johnson RD, Davis GE, Sumanas S. SH2 domain protein E and ABL signaling regulate blood vessel size. PLoS Genet. 2024 Jan 8;20(1):e1010851. doi: 10.1371/journal.pgen.1010851. Online ahead of print.

The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development

Authors:
Song X, Hu R, Chen Y, Xiao M, Zhang H, Wu S, Lu Q
Citation:
J Mol Cell Biol. 2024 Jan 4:mjad083. doi: 10.1093/jmcb/mjad083. Online ahead of print
Epub:
Yes
Abstract:
TRAF7 serves as a crucial intracellular adaptor and E3 ubiquitin ligase involved in signal transduction pathways, contributing...
Link:
https://academic.oup.com/jmcb/advance-article/doi/10.1093/jmcb/mjad083/7511116
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Song X, Hu R, Chen Y, Xiao M, Zhang H, Wu S, Lu Q. The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development. J Mol Cell Biol. 2024 Jan 4:mjad083. doi: 10.1093/jmcb/mjad083. Online ahead of print.

ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation

Authors:
Wang C, Liu Z, Zeng Y, Zhou L, Long Q, Hassan IU, Zhang Y, Qi X, Cai D, Mao B, Lu G, Sun J, Yao Y, Deng Y, Zhao Q, Feng B, Zhou Q, Chan WY, Zhao H
Citation:
EMBO Rep. 2024 Jan 2. doi: 10.1038/s44319-023-00046-w. Online ahead of print
Epub:
Yes
Abstract:
The dorsoventral gradient of BMP signaling plays an essential role in embryonic patterning. Zinc Finger SWIM-Type Containing 4...
Link:
https://www.embopress.org/doi/full/10.1038/s44319-023-00046-w
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Wang C, Liu Z, Zeng Y, Zhou L, Long Q, Hassan IU, Zhang Y, Qi X, Cai D, Mao B, Lu G, Sun J, Yao Y, Deng Y, Zhao Q, Feng B, Zhou Q, Chan WY, Zhao H. ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation. EMBO Rep. 2024 Jan 2. doi: 10.1038/s44319-023-00046-w. Online ahead of print.

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