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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Regulatory circuit rewiring and functional divergence of the duplicate admp genes in dorsoventral axial patterning

Authors:
Chang YC, Pai CY, Chen YC, Ting HC, Martinez P, Telford MJ, Yu JK, Su YH
Citation:
Dev Biol. 2015 Dec 21. pii: S0012-1606(15)30365-1. doi: 10.1016/j.ydbio.2015.12.015. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The spatially opposed expression of Antidorsalizing morphogenetic protein (Admp) and BMP signals controls dorsoventral (DV)...
Organism or Cell Type:
Sea urchin
Citation Extract:
Chang YC, Pai CY, Chen YC, Ting HC, Martinez P, Telford MJ, Yu JK, Su YH. Regulatory circuit rewiring and functional divergence of the duplicate admp genes in dorsoventral axial patterning. Dev Biol. 2015 Dec 21. pii: S0012-1606(15)30365-1. doi: 10.1016/j.ydbio.2015.12.015. [Epub ahead of print].

Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression

Authors:
Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI
Citation:
Blood. 2015 Dec 24;126(26):2811-20. doi: 10.1182/blood-2015-07-659276. Epub 2015 Sep 18
Epub:
Not Epub
Abstract:
Rare endothelial cells in the aorta-gonad-mesonephros (AGM) transition into hematopoietic stem cells (HSCs) during embryonic...
Organism or Cell Type:
zebrafish
Citation Extract:
Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24;126(26):2811-20. doi: 10.1182/blood-2015-07-659276. Epub 2015 Sep 18.

A Boolean Function for Neural Induction Reveals a Critical Role of Direct Intercellular Interactions in Patterning the Ectoderm of the Ascidian Embryo

Authors:
Ohta N, Waki K, Mochizuki A, Satou Y
Citation:
PLoS Comput Biol. 2015 Dec 29;11(12):e1004687. doi: 10.1371/journal.pcbi.1004687. eCollection 2015 Dec
Epub:
Not Epub
Abstract:
A complex system of multiple signaling molecules often produce differential gene expression patterns in animal embryos. In the...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Ohta N, Waki K, Mochizuki A, Satou Y. A Boolean Function for Neural Induction Reveals a Critical Role of Direct Intercellular Interactions in Patterning the Ectoderm of the Ascidian Embryo. PLoS Comput Biol. 2015 Dec 29;11(12):e1004687. doi: 10.1371/journal.pcbi.1004687. eCollection 2015 Dec.

Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation

Authors:
Cheng YC, Huang YC, Yeh TH, Shih HY, Lin CY, Lin SJ, Chiu CC, Huang CW, Jiang YJ
Citation:
Neural Dev. 2015 Dec 30;10(1):28. doi: 10.1186/s13064-015-0055-5
Epub:
Not Epub
Abstract:
BACKGROUND: Notch signaling has been conserved throughout evolution and plays a fundamental role in various neural...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng YC, Huang YC, Yeh TH, Shih HY, Lin CY, Lin SJ, Chiu CC, Huang CW, Jiang YJ. Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural Dev. 2015 Dec 30;10(1):28. doi: 10.1186/s13064-015-0055-5.

A novel role for ASCL1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT function

Authors:
Gao L, Zhu X, Chen G, Ma X, Zhang Y, Khand AA, Shi H, Gu F, Lin H, Chen Y, Zhang H, He L, Tao Q
Citation:
Development. 2015;[Epub ahead of print] doi:10.1242/dev.126292
Epub:
Yes
Abstract:
Maternally expressed proteins function in vertebrates to establish the major body axes of the embryo, and to establish a pre-...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gao L, Zhu X, Chen G, Ma X, Zhang Y, Khand AA, Shi H, Gu F, Lin H, Chen Y, Zhang H, He L, Tao Q. A novel role for ASCL1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT function. Development. 2015;[Epub ahead of print] doi:10.1242/dev.126292 .

Recessive mutations in the α3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia

Authors:
Zech M, Lam DD, Francescatto L, Schormair B, Salminen AV, Jochim A, Wieland T, Lichtner P, Peters A, Gieger C, Lochmüller H, Strom TM, Haslinger B, Katsanis N, Winkelmann J
Citation:
Am J Hum Genet. 2015 Jun 4;96(6):883-93. doi: 10.1016/j.ajhg.2015.04.010. Epub 2015 May 21
Epub:
Not Epub
Abstract:
Isolated dystonia is a disorder characterized by involuntary twisting postures arising from sustained muscle contractions....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zech M, Lam DD, Francescatto L, Schormair B, Salminen AV, Jochim A, Wieland T, Lichtner P, Peters A, Gieger C, Lochmüller H, Strom TM, Haslinger B, Katsanis N, Winkelmann J. Recessive mutations in the α3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia. Am J Hum Genet. 2015 Jun 4;96(6):883-93. doi: 10.1016/j.ajhg.2015.04.010. Epub 2015 May 21.

Genetic pathways for differentiation of the peripheral nervous system in ascidians

Authors:
Waki K, Imai KS, Satou Y
Citation:
Nat Commun. 2015 Oct 30;6:8719. doi: 10.1038/ncomms9719
Epub:
Not Epub
Abstract:
Ascidians belong to tunicates, the sister group of vertebrates. Peripheral nervous systems (PNSs) including epidermal sensory...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Waki K, Imai KS, Satou Y. Genetic pathways for differentiation of the peripheral nervous system in ascidians. Nat Commun. 2015 Oct 30;6:8719. doi: 10.1038/ncomms9719.

Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Authors:
Roy S, Šileikytė J, Schiavone M, Neuenswander B, Argenton F, Aubé J, Hedrick MP, Chung TD, Forte MA, Bernardi P, Schoenen FJ
Citation:
ChemMedChem. 2015 Oct;10(10):1655-71. doi: 10.1002/cmdc.201500284. Epub 2015 Aug 18
Epub:
Not Epub
Abstract:
The mitochondrial permeability transition pore (mtPTP) is a Ca2+-requiring mega-channel which, under pathological conditions,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Roy S, Šileikytė J, Schiavone M, Neuenswander B, Argenton F, Aubé J, Hedrick MP, Chung TD, Forte MA, Bernardi P, Schoenen FJ. Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore. ChemMedChem. 2015 Oct;10(10):1655-71. doi: 10.1002/cmdc.201500284. Epub 2015 Aug 18.

A susceptibility locus rs7099208 is associated with non-obstructive azoospermia via reduction in the expression of FAM160B1

Authors:
Zhang Y, Qian J, Wu M, Liu M, Zhang K, Lin Y, Guo X, Zhou Z, Hu Z, Sha J
Citation:
J Biomed Res. 2015 Nov;29(6):491-500. doi: 10.7555/JBR.29.20150034. Epub 2015 Aug 8. Erratum in: J Biomed Res. 2015 Nov;29(6):518
Epub:
Not Epub
Abstract:
Non-obstructive azoospermia (NOA) is a severe defect in male reproductive health that occurs in 1% of adult men. In a previous...
Organism or Cell Type:
cell culture: mouse spermatocyte GC2-spd
Citation Extract:
Zhang Y, Qian J, Wu M, Liu M, Zhang K, Lin Y, Guo X, Zhou Z, Hu Z, Sha J. A susceptibility locus rs7099208 is associated with non-obstructive azoospermia via reduction in the expression of FAM160B1. J Biomed Res. 2015 Nov;29(6):491-500. doi: 10.7555/JBR.29.20150034. Epub 2015 Aug 8. Erratum in: J Biomed Res. 2015 Nov;29(6):518.

ZBTB42 mutation defines a novel lethal congenital contracture syndrome (LCCS6)

Authors:
Patel N, Smith LL, Faqeih E, Mohamed J, Gupta VA, Alkuraya FS
Citation:
Hum Mol Genet. 2014 Dec 15;23(24):6584-93. doi: 10.1093/hmg/ddu384. Epub 2014 Jul 23
Epub:
Not Epub
Abstract:
Lethal congenital contracture syndrome (LCCS) is a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Patel N, Smith LL, Faqeih E, Mohamed J, Gupta VA, Alkuraya FS. ZBTB42 mutation defines a novel lethal congenital contracture syndrome (LCCS6). Hum Mol Genet. 2014 Dec 15;23(24):6584-93. doi: 10.1093/hmg/ddu384. Epub 2014 Jul 23.

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