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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Xom induces proteolysis of β-catenin through GSK3β-mediated pathway

Authors:
Wu B, Gao H, Le Y, Wu X, Zhu Z
Citation:
FEBS Lett. 2017 Dec 18. doi: 10.1002/1873-3468.12949. [Epub ahead of print]
Epub:
Yes
Abstract:
The dorsal cell fate determination factor β-catenin and its antagonist, the ventral cell fate determination factor Xom, are...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12949/abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Wu B, Gao H, Le Y, Wu X, Zhu Z. Xom induces proteolysis of β-catenin through GSK3β-mediated pathway. FEBS Lett. 2017 Dec 18. doi: 10.1002/1873-3468.12949. [Epub ahead of print].

Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish

Authors:
He J, Yang Y, Zhang J, Chen J, Wei X, He J, Luo L
Citation:
J Genet Genomics. 2017 Nov 29. pii: S1673-8527(17)30198-4. doi: 10.1016/j.jgg.2017.09.013. [Epub ahead of print]
Epub:
Yes
Abstract:
Ribosome biogenesis is essential for the cell growth and division. Disruptions in ribosome biogenesis result in developmental...
Link:
http://www.sciencedirect.com/science/article/pii/S1673852717301984
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
He J, Yang Y, Zhang J, Chen J, Wei X, He J, Luo L. Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish. J Genet Genomics. 2017 Nov 29. pii: S1673-8527(17)30198-4. doi: 10.1016/j.jgg.2017.09.013. [Epub ahead of print].

Tween 85-Modified Low Molecular Weight PEI Enhances Exon-Skipping of Antisense Morpholino Oligomer In Vitro and in mdx Mice

Authors:
Wang M, Wu B, Tucker JD, Shah SN, Lu P, Bollinger LE, Lu Q
Citation:
Mol Ther Nucleic Acids. 2017 Dec 15;9:120-131. doi: 10.1016/j.omtn.2017.09.006. Epub 2017 Sep 20
Epub:
Not Epub
Abstract:
We investigated a series of Tween 85 modified low molecular weight polyethylenimine (LPEI, 0.8k/1.2k/2.0k)-copolymers (Zs)...
Link:
http://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(17)30256-1
Delivery Method:
Tween 85-Modified PEI, Endo-Porter (delivery control)
Organism or Cell Type:
cell culture: C2C12E50, C2C12E23; mdx mice
Citation Extract:
Wang M, Wu B, Tucker JD, Shah SN, Lu P, Bollinger LE, Lu Q. Tween 85-Modified Low Molecular Weight PEI Enhances Exon-Skipping of Antisense Morpholino Oligomer In Vitro and in mdx Mice. Mol Ther Nucleic Acids. 2017 Dec 15;9:120-131. doi: 10.1016/j.omtn.2017.09.006. Epub 2017 Sep 20.

Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation

Authors:
van der Vaart M, Svoboda O, Weijts BG, Espín-Palazón R, Sapp V, Pietri T, Bagnat M, Muotri AR, Traver D
Citation:
Dis Model Mech. 2017 Oct 9. pii: dmm.026922. doi: 10.1242/dmm.026922. [Epub ahead of print]
Epub:
Yes
Abstract:
Mutations in MECP2 cause Rett syndrome, a severe neurological disorder with autism-like features. Duplication of MECP2 also...
Link:
http://dmm.biologists.org/content/10/12/1439
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
van der Vaart M, Svoboda O, Weijts BG, Espín-Palazón R, Sapp V, Pietri T, Bagnat M, Muotri AR, Traver D. Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation. Dis Model Mech. 2017 Oct 9. pii: dmm.026922. doi: 10.1242/dmm.026922. [Epub ahead of print].

Notch-mediated lateral inhibition is an evolutionarily conserved mechanism patterning the ectoderm in echinoids

Authors:
Erkenbrack EM
Citation:
Dev Genes Evol. 2017;{Epub ahead or print] doi:10.1007/s00427-017-0599-y
Epub:
Yes
Abstract:
Notch signaling is a crucial cog in early development of euechinoid sea urchins, specifying both non-skeletogenic mesodermal...
Link:
https://link.springer.com/article/10.1007/s00427-017-0599-y
Delivery Method:
microinjection
Organism or Cell Type:
Eucidaris tribuloides (sea urchin)
Citation Extract:
Erkenbrack EM. Notch-mediated lateral inhibition is an evolutionarily conserved mechanism patterning the ectoderm in echinoids. Dev Genes Evol. 2017;{Epub ahead or print] doi:10.1007/s00427-017-0599-y.

Single-cell transcriptome analysis of avian neural crest migration reveals signatures of invasion and molecular transitions

Authors:
Morrison JA, McLennan R, Wolfe LA, Gogol MM, Meier S, McKinney MC, Teddy JM, Holmes L, Semerad CL, Box AC, Li H, Hall KE, Perera AG, Kulesa PM
Citation:
Elife. 2017 Dec 4;6. pii: e28415. doi: 10.7554/eLife.28415
Epub:
Not Epub
Abstract:
Neural crest cells migrate throughout the embryo, but how cells move in a directed and collective manner has remained unclear....
Link:
https://elifesciences.org/articles/28415
Delivery Method:
Endo-Porter (cultures), injection then electroporation (embryos)
Organism or Cell Type:
cell culture: LMH cell line, Gallus gallus (chick)
Citation Extract:
Morrison JA, McLennan R, Wolfe LA, Gogol MM, Meier S, McKinney MC, Teddy JM, Holmes L, Semerad CL, Box AC, Li H, Hall KE, Perera AG, Kulesa PM. Single-cell transcriptome analysis of avian neural crest migration reveals signatures of invasion and molecular transitions. Elife. 2017 Dec 4;6. pii: e28415. doi: 10.7554/eLife.28415.

Activation of Lysophosphatidic Acid Receptor 3 Inhibits Megakaryopoiesis in Human Hematopoietic Stem Cells and Zebrafish

Authors:
Lin KH, Li MW, Chang YC, Lin YN, Ho YH, Weng WC, Huang CJ, Chang BE, Yao CL, Lee H
Citation:
Stem Cells Dev. 2017 Dec 14. doi: 10.1089/scd.2017.0190. [Epub ahead of print]
Epub:
Yes
Abstract:
Lysophosphatidic acid (LPA) is a membrane-derived lysophospholipid that exists in the plasma and platelets. It exerts its...
Link:
http://online.liebertpub.com/doi/abs/10.1089/scd.2017.0190
Organism or Cell Type:
zebrafish
Citation Extract:
Lin KH, Li MW, Chang YC, Lin YN, Ho YH, Weng WC, Huang CJ, Chang BE, Yao CL, Lee H. Activation of Lysophosphatidic Acid Receptor 3 Inhibits Megakaryopoiesis in Human Hematopoietic Stem Cells and Zebrafish. Stem Cells Dev. 2017 Dec 14. doi: 10.1089/scd.2017.0190. [Epub ahead of print].

ABIN-1 negatively Regulates μ-opioid Receptor Function

Authors:
Zhou P, Jiang J, Yan H, Li Y, Zhao J, Wang X, Su R, Gong Z
Citation:
Mol Pharmacol. 2017 Dec 13. pii: mol.117.109009. doi: 10.1124/mol.117.109009. [Epub ahead of print]
Epub:
Yes
Abstract:
The μ-opioid receptor (MOR) is a Gi/o protein-coupled receptor that mediates analgesic, euphoric, and reward effects. Using a...
Link:
http://molpharm.aspetjournals.org/content/early/2017/12/13/mol.117.109009
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou P, Jiang J, Yan H, Li Y, Zhao J, Wang X, Su R, Gong Z. ABIN-1 negatively Regulates μ-opioid Receptor Function. Mol Pharmacol. 2017 Dec 13. pii: mol.117.109009. doi: 10.1124/mol.117.109009. [Epub ahead of print].

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension

Authors:
Miles LB, Darido C, Kaslin J, Heath JK, Jane SM, Dworkin S
Citation:
Sci Rep. 2017;7:17607. doi:10.1038/s41598-017-17898-7
Epub:
Not Epub
Abstract:
The grainyhead-like (grhl) transcription factors play crucial roles in craniofacial development, epithelial morphogenesis,...
Link:
https://www.nature.com/articles/s41598-017-17898-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Miles LB, Darido C, Kaslin J, Heath JK, Jane SM, Dworkin S. Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension. Sci Rep. 2017;7:17607. doi:10.1038/s41598-017-17898-7.

Tissue-Resident TSP1-CD47 Signaling Promotes Sickle Cell-Associated Arterial Vasculopathy and Pulmonary Hypertension

Authors:
Novelli EM, Ihrig LL, Knupp HE, Rogers NM, Yao M, Huang X, Baust J, Meijles D, St Croix CM, Ross MA, Pagano PJ, Champion HC, Miles G, Potoka KP, Gladwin MT, Isenberg JS
Citation:
Blood, 2017;130(Suppl 1):957
Epub:
Not Epub
Abstract:
Pulmonary hypertension (PH) is a chronic pulmonary complication of sickle cell disease (SCD) and a leading cause of death in...
Link:
http://www.bloodjournal.org/content/130/Suppl_1/957
Delivery Method:
i.p. injection
Organism or Cell Type:
mice
Citation Extract:
Novelli EM, Ihrig LL, Knupp HE, Rogers NM, Yao M, Huang X, Baust J, Meijles D, St Croix CM, Ross MA, Pagano PJ, Champion HC, Miles G, Potoka KP, Gladwin MT, Isenberg JS. Tissue-Resident TSP1-CD47 Signaling Promotes Sickle Cell-Associated Arterial Vasculopathy and Pulmonary Hypertension. Blood, 2017;130(Suppl 1):957.

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