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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation
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Citation:
Sci Adv. 2018;4:eaao1261 doi:10.1126/sciadv.aao1261 Epub:
Not Epub Abstract:
Retinoic acid (RA) is an important intercellular signaling molecule in vertebrate development, with a well-established role in... Delivery Method:
microinjection Organism or Cell Type:
Platynereis dumerilii (annelid) Citation Extract: Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Nadendla EK, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M. The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation. Sci Adv. 2018;4:eaao1261 doi:10.1126/sciadv.aao1261. |
Repurposing Dantrolene for Long-term Combination Therapy to Potentiate Antisense-Mediated DMD Exon-Skipping in the mdx mouse
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Citation:
Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.002 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, essential to muscle health.... Delivery Method:
retroorbital injection Organism or Cell Type:
mice mdx Citation Extract: Wang DW, Mokhonova EI, Genevieve C. Kendall GC, Becerra D, Naeini YB, Cantor RM, Spencer MJ, Nelson SF, Miceli MC. Repurposing Dantrolene for Long-term Combination Therapy to Potentiate Antisense-Mediated DMD Exon-Skipping in the mdx mouse. Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.002. |
A dystrophic Duchenne mouse model for testing human antisense oligonucleotides
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Citation:
PLoS ONE. 2018;13(2):e0193289. doi:10.1371/journal.pone.0193289 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease generally caused by reading frame disrupting mutations in... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
del52hDMD/mdx mouse Citation Extract: Veltrop M, van Vliet L, Hulsker M, Claassens J, Brouwers C, Breukel C, van der Kaa J, Linssen MM, den Dunnen JT, Verbeek S, Aartsma-Rus A, van Putten M. A dystrophic Duchenne mouse model for testing human antisense oligonucleotides. PLoS ONE. 2018;13(2):e0193289. doi:10.1371/journal.pone.0193289. |
Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery in vitro and in mdx Mice
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Citation:
Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.004 Epub:
Yes Abstract:
Antisense oligonucleotide (AON) therapy for Duchenne muscular dystrophy has drawn great attention in preclinical and clinical... Delivery Method:
Endo-Porter or Saponin in culture, injection in mice Organism or Cell Type:
cell culture: C2C12E50, C2C12E23; mice, mdx Citation Extract: Wang M, Wu B, Shah SN, Lu P, Lu Q. Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery in vitro and in mdx Mice. Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.004. |
Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates
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Citation:
Proc Natl Acad Sci U S A. 2018 Feb 9. pii: 201711516. doi: 10.1073/pnas.1711516115. [Epub ahead of print] Epub:
Yes Abstract:
Robust morphogenetic events are pivotal for animal embryogenesis. However, comparison of the modes of development of different... Delivery Method:
microinjection Organism or Cell Type:
Nematostella vectensis (sea anemone) Citation Extract: Kirillova A, Genikhovich G, Pukhlyakova E, Demilly A, Kraus Y, Technau U. Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates. Proc Natl Acad Sci U S A. 2018 Feb 9. pii: 201711516. doi: 10.1073/pnas.1711516115. [Epub ahead of print]. |
Antisense inhibitors retain activity in pulmonary models of Burkholderia infection
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Citation:
ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print] Epub:
Yes Abstract:
The Burkholderia cepacia complex is a group of gram-negative bacteria that are opportunistic pathogens in immunocompromised... Delivery Method:
peptide-linked Organism or Cell Type:
Burkholderia cepacia, Pseudomonas Citation Extract: Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller B, Greenberg D. Antisense inhibitors retain activity in pulmonary models of Burkholderia infection. ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print]. |
Amplification-free detection of DNA in a paper-based microfluidic device using electroosmotically balanced isotachophoresis
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Citation:
Lab Chip. 2018 Feb 20. doi: 10.1039/c7lc01250k. [Epub ahead of print] Epub:
Not Epub Abstract:
We present a novel microfluidic paper-based analytical device (μPAD) which utilizes the native high electroosmotic flow (EOF)... Citation Extract: Rosenfeld T, Bercovici M. Amplification-free detection of DNA in a paper-based microfluidic device using electroosmotically balanced isotachophoresis. Lab Chip. 2018 Feb 20. doi: 10.1039/c7lc01250k. [Epub ahead of print]. |
Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype
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Citation:
Hum Molec Genet. 20-18;26(21):4168-80. doi:10.1093/hmg/ddx305 Epub:
Not Epub Abstract:
Cell Division Cycle 6 (Cdc6) is a component of pre-replicative complex (preRC) forming on DNA replication origins in eukaryotes... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yao L, Chen J, Wu X, Jia S, Meng A. Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Hum Molec Genet. 20-18;26(21):4168-80. doi:10.1093/hmg/ddx305. |
The Beta-Adrenergic Agonist Salbutamol Modulates Neuromuscular Junction Formation in Zebrafish Models of Human Myasthenic Syndromes
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Citation:
Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy062 Epub:
Yes Abstract:
Inherited defects of the neuromuscular junction (NMJ) comprise an increasingly diverse range of disorders, termed congenital... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: McMacken G, Cox D, Roos A, Müller J, Whittaker R, Lochmüller H. The Beta-Adrenergic Agonist Salbutamol Modulates Neuromuscular Junction Formation in Zebrafish Models of Human Myasthenic Syndromes. Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy062. |
MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion
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Citation:
Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy054 Epub:
Yes Abstract:
Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterised by compromised function of the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: O’Connor E, Phan V, Cordts I, Cairns G, Hettwer S, Cox D, Lochmüller H, Roos A. MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion. Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy054. |