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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease

Authors:
Uusimaa J, Kaarteenaho R, Paakkola T, Tuominen H, Karjalainen MK, Nadaf J,Varilo T, Uusi-Mäkelä M, Suo-Palosaari M, Pietilä I, Hiltunen AE, Ruddock L, Alanen H, Biterova E, Miinalainen I, Salminen A, Soininen R, Manninen A, Sormunen R, Kaakinen M, Vuolteenaho R, Herva R, Vieira P, Teija Dunder T, Kokkonen H, Moilanen JS, Rantala H, Nogee LM, Majewski J, Rämet M, Hallman M, Hinttala R
Citation:
Acta Neuropath. 2018;[Epub ahead of print] doi:10.1007/s00401-018-1817-z
Epub:
Not Epub
Abstract:
A novel multi-organ disease that is fatal in early childhood was identified in three patients from two non-consanguineous...
Link:
https://link.springer.com/article/10.1007%2Fs00401-018-1817-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Uusimaa J, Kaarteenaho R, Paakkola T, Tuominen H, Karjalainen MK, Nadaf J,Varilo T, Uusi-Mäkelä M, Suo-Palosaari M, Pietilä I, Hiltunen AE, Ruddock L, Alanen H, Biterova E, Miinalainen I, Salminen A, Soininen R, Manninen A, Sormunen R, Kaakinen M, Vuolteenaho R, Herva R, Vieira P, Teija Dunder T, Kokkonen H, Moilanen JS, Rantala H, Nogee LM, Majewski J, Rämet M, Hallman M, Hinttala R. NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease. Acta Neuropath. 2018;[Epub ahead of print] doi:10.1007/s00401-018-1817-z.

Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis

Authors:
Donat S, Lourenço M, Paolini A, Otten C, Renz M, Abdelilah-Seyfried S
Citation:
Elife. 2018 Feb 1;7. pii: e28939. doi: 10.7554/eLife.28939
Epub:
Not Epub
Abstract:
Endothelial cells respond to different levels of fluid shear stress through adaptations of their mechanosensitivity. Currently...
Link:
https://elifesciences.org/articles/28939
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Donat S, Lourenço M, Paolini A, Otten C, Renz M, Abdelilah-Seyfried S. Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis. Elife. 2018 Feb 1;7. pii: e28939. doi: 10.7554/eLife.28939.

Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling

Authors:
Krispin S, Stratman AN, Melick CH, Stan RV, Malinverno M, Gleklen J, Castranova D, Dejana E, Weinstein BM
Citation:
Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):353-362. doi: 10.1161/ATVBAHA.117.309571. Epub 2017 Dec 28
Epub:
Not Epub
Abstract:
OBJECTIVE: The assembly of a functional vascular system requires a coordinated and dynamic transition from activation to...
Link:
http://atvb.ahajournals.org/content/38/2/353
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Krispin S, Stratman AN, Melick CH, Stan RV, Malinverno M, Gleklen J, Castranova D, Dejana E, Weinstein BM. Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):353-362. doi: 10.1161/ATVBAHA.117.309571. Epub 2017 Dec 28.

Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein

Authors:
Sztal TE, McKaige EA, Williams C, Ruparelia AA, Bryson-Richardson RJ
Citation:
PLoS Genet. 2018;14(2):e1007212. doi:10.1371/journal.pgen.1007212
Epub:
Not Epub
Abstract:
The lack of a mutant phenotype in homozygous mutant individuals’ due to compensatory gene expression triggered upstream of...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007212
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sztal TE, McKaige EA, Williams C, Ruparelia AA, Bryson-Richardson RJ. Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. PLoS Genet. 2018;14(2):e1007212. doi:10.1371/journal.pgen.1007212.

Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep

Authors:
Lenis YY, Johnson GA, Wang X, Tang WW, Dunlap KA, Satterfield MC, Wu G, Hansen TR, Bazer FW
Citation:
J Anim Sci Biotechnol. 2018 Jan 24;9:10. doi: 10.1186/s40104-017-0225-x. eCollection 2018
Epub:
Not Epub
Abstract:
Background: Polyamines stimulate DNA transcription and mRNA translation for protein synthesis in trophectoderm cells, as well...
Link:
https://jasbsci.biomedcentral.com/articles/10.1186/s40104-017-0225-x
Delivery Method:
Endo-Porter
Organism or Cell Type:
Ovis aries (sheep)
Citation Extract:
Lenis YY, Johnson GA, Wang X, Tang WW, Dunlap KA, Satterfield MC, Wu G, Hansen TR, Bazer FW. Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep. J Anim Sci Biotechnol. 2018 Jan 24;9:10. doi: 10.1186/s40104-017-0225-x. eCollection 2018.

Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi syndrome in zebrafish

Authors:
Babu A, Kamaraj M, Basu M, Mukherjee D, Kapoor S, Ranjan S, Swamy MM, Kaypee S, Scaria V, Kundu TK, Sachidanandan C
Citation:
Biochim Biophys Acta. 2018 Jan 30. pii: S0925-4439(18)30040-1. doi: 10.1016/j.bbadis.2018.01.029. [Epub ahead of print]
Epub:
Yes
Abstract:
EP300 is a member of the EP300/CBP family of lysine acetyltransferases (KATs) with multiple roles in development and physiology...
Link:
https://www.sciencedirect.com/science/article/pii/S0925443918300401
Organism or Cell Type:
zebrafish
Citation Extract:
Babu A, Kamaraj M, Basu M, Mukherjee D, Kapoor S, Ranjan S, Swamy MM, Kaypee S, Scaria V, Kundu TK, Sachidanandan C. Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi syndrome in zebrafish. Biochim Biophys Acta. 2018 Jan 30. pii: S0925-4439(18)30040-1. doi: 10.1016/j.bbadis.2018.01.029. [Epub ahead of print].

Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors

Authors:
Saera-Vila A, Louie KW, Sha C, Kelly RM, Kish PE, Kahana A
Citation:
PLoS ONE. 2018;13(2):e0192214. doi:10.1371/journal.pone.0192214
Epub:
Not Epub
Abstract:
Insulin-like growth factors (Igfs) are key regulators of key biological processes such as embryonic development, growth, and...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192214
Delivery Method:
electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Saera-Vila A, Louie KW, Sha C, Kelly RM, Kish PE, Kahana A. Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors. PLoS ONE. 2018;13(2):e0192214. doi:10.1371/journal.pone.0192214.

Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation

Authors:
Yan MS, Turgeon PJ, Man HSJ, Dubinsky MK, Ho Jr JD, El-Rass S, Wang Y-D, Wen X-Y, Marsden PA
Citation:
J Biol Chem. 2018;[Epub ahead of print] doi:10.1074/jbc.RA117.001383
Epub:
Yes
Abstract:
Although the functional role of chromatin marks at promoters in mediating cell-restricted gene expression has been well...
Link:
http://www.jbc.org/content/early/2018/02/06/jbc.RA117.001383.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yan MS, Turgeon PJ, Man HSJ, Dubinsky MK, Ho Jr JD, El-Rass S, Wang Y-D, Wen X-Y, Marsden PA. Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation. J Biol Chem. 2018;[Epub ahead of print] doi:10.1074/jbc.RA117.001383.

Deficiency of a novel gene, Yulink, predisposes to heart failure and ventricular arrhythmia

Authors:
Tsai CT, Kuo MW, Lin JL, Yu AL, Yu J
Citation:
FASEB J. 2018 Jan 11:fj201700932RR. doi: 10.1096/fj.201700932RR. [Epub ahead of print]
Epub:
Yes
Abstract:
Heart failure is a major cardiovascular disease and is associated with significant morbidity and mortality. Sudden cardiac...
Link:
http://www.fasebj.org/doi/abs/10.1096/fj.201700932RR
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tsai CT, Kuo MW, Lin JL, Yu AL, Yu J. Deficiency of a novel gene, Yulink, predisposes to heart failure and ventricular arrhythmia. FASEB J. 2018 Jan 11:fj201700932RR. doi: 10.1096/fj.201700932RR. [Epub ahead of print].

Modifier variant of METTL13 suppresses human GAB1-associated profound deafness

Authors:
Yousaf R, Ahmed ZM, Giese AP, Morell RJ, Lagziel A, Dabdoub A, Wilcox ER, Riazuddin S, Friedman TB, Riazuddin S
Citation:
J Clin Invest. 2018 Feb 6. pii: 97350. doi: 10.1172/JCI97350. [Epub ahead of print]
Epub:
Yes
Abstract:
A modifier variant can abrogate risk of a monogenic disorder. DFNM1 is a locus on chromosome 1 encoding a dominant suppressor...
Link:
https://www.jci.org/articles/view/97350
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yousaf R, Ahmed ZM, Giese AP, Morell RJ, Lagziel A, Dabdoub A, Wilcox ER, Riazuddin S, Friedman TB, Riazuddin S. Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. J Clin Invest. 2018 Feb 6. pii: 97350. doi: 10.1172/JCI97350. [Epub ahead of print].

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