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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Polycystin-1 loss-of-function is directly linked to an imbalance in G-Protein signaling in the kidney

Authors:
Zhang B, Tran U, Wessely O
Citation:
Development. 2018 Mar 12. pii: dev.158931. doi: 10.1242/dev.158931. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The development of the kidney relies on the establishment and maintenance of a precise tubular diameter of its functional units...
Link:
dev.biologists.org/content/early/2018/03/08/dev.158931
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Zhang B, Tran U, Wessely O. Polycystin-1 loss-of-function is directly linked to an imbalance in G-Protein signaling in the kidney. Development. 2018 Mar 12. pii: dev.158931. doi: 10.1242/dev.158931. [Epub ahead of print].

A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations

Authors:
Keßler M, Kieltsch A, Kayvanpour E, Katus HA, Schoser B, Schessl J, Just S, Rottbauer W
Citation:
Neuromusc Disord. 2018;[Epub ahead of print] doi:10.1016/j.nmd.2018.03.001
Epub:
Yes
Abstract:
Missense mutations in the four and a half LIM domain 1 (FHL1) gene were found to cause X-linked inherited myopathies of both...
Link:
https://www.sciencedirect.com/science/article/pii/S0960896617312658
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Keßler M, Kieltsch A, Kayvanpour E, Katus HA, Schoser B, Schessl J, Just S, Rottbauer W. A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations. Neuromusc Disord. 2018;[Epub ahead of print] doi:10.1016/j.nmd.2018.03.001.

TBX20 Regulates Angiogenesis Through the PROK2-PROKR1 Pathway

Authors:
Meng S, Gu Q, Yang X, Lv J, Owusu I, Matrone G, Chen K, Cooke JP, Fang L
Citation:
Circulation. 2018 Mar 15. pii: CIRCULATIONAHA.118.033939. doi: 10.1161/CIRCULATIONAHA.118.033939. [Epub ahead of print]
Epub:
Yes
Abstract:
Background -Angiogenesis is integral for embryogenesis, and targeting angiogenesis improves the outcome of many pathological...
Link:
http://circ.ahajournals.org/content/early/2018/03/13/CIRCULATIONAHA.118.033939.long
Organism or Cell Type:
zebrafish
Citation Extract:
Meng S, Gu Q, Yang X, Lv J, Owusu I, Matrone G, Chen K, Cooke JP, Fang L. TBX20 Regulates Angiogenesis Through the PROK2-PROKR1 Pathway. Circulation. 2018 Mar 15. pii: CIRCULATIONAHA.118.033939. doi: 10.1161/CIRCULATIONAHA.118.033939. [Epub ahead of print].

Pitx1 regulates cement gland development in Xenopus laevis through activation of transcriptional targets and inhibition of BMP signaling

Authors:
Jin Y, Weinstein DC
Citation:
Dev Biol. 2018 Mar 9. pii: S0012-1606(17)30225-7. doi: 10.1016/j.ydbio.2018.03.008. [Epub ahead of print]
Epub:
Yes
Abstract:
The cement gland in Xenopus laevis has long been used as a model to study the interplay of cell signaling and transcription...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160617302257
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Jin Y, Weinstein DC. Pitx1 regulates cement gland development in Xenopus laevis through activation of transcriptional targets and inhibition of BMP signaling. Dev Biol. 2018 Mar 9. pii: S0012-1606(17)30225-7. doi: 10.1016/j.ydbio.2018.03.008. [Epub ahead of print].

Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway

Authors:
Xu D, Lv J, He L, Fu L, Hu R, Cao Y, Mei C
Citation:
FASEB J. 2018 Mar 12:fj201701376RR. doi: 10.1096/fj.201701376RR. [Epub ahead of print]
Epub:
Yes
Abstract:
Polarity complexes, including the PAR (Partitioning-defective), CRB (Crumbs) and SCRIB (Scribble) complexes, are required for...
Link:
http://www.fasebj.org/doi/abs/10.1096/fj.201701376RR
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu D, Lv J, He L, Fu L, Hu R, Cao Y, Mei C. Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway. FASEB J. 2018 Mar 12:fj201701376RR. doi: 10.1096/fj.201701376RR. [Epub ahead of print].

Role of zebrafish fhl1A in satellite cell and skeletal muscle development

Authors:
Chen F, Yuan W, Mo X, Zhuang J, Wang Y, Chen J, Jiang Z, Zhu X, Zeng Q, Wan Y, Li F, Shi Y, Cao L, Fan X, Luo S, Ye X, Chen Y, Dai G, Gao J, Wang X, Xie H, Zhu P, Li Y, Wu X
Citation:
Curr Mol Med. 2018 Mar 7. doi: 10.2174/1566524018666180308113909. [Epub ahead of print]
Epub:
Yes
Abstract:
Four-and-a-half LIM domains protein 1 (FHL1) mutations are associated with human myopathies. However, the function of this...
Link:
http://www.eurekaselect.com/160312/article
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen F, Yuan W, Mo X, Zhuang J, Wang Y, Chen J, Jiang Z, Zhu X, Zeng Q, Wan Y, Li F, Shi Y, Cao L, Fan X, Luo S, Ye X, Chen Y, Dai G, Gao J, Wang X, Xie H, Zhu P, Li Y, Wu X. Role of zebrafish fhl1A in satellite cell and skeletal muscle development. Curr Mol Med. 2018 Mar 7. doi: 10.2174/1566524018666180308113909. [Epub ahead of print].

Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity

Authors:
Zhang X, Kim CY, Worthen T, Witola WH
Citation:
Int J Parasitol. 2018 Mar 9. pii: S0020-7519(18)30056-0. doi: 10.1016/j.ijpara.2018.01.005. [Epub ahead of print]
Epub:
Yes
Abstract:
Cryptosporidium is a highly prevalent protozoan parasite that is the second leading cause of childhood morbidity and mortality...
Link:
https://www.sciencedirect.com/science/article/pii/S0020751918300560
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Cryptosporidium parvum
Citation Extract:
Zhang X, Kim CY, Worthen T, Witola WH. Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity. Int J Parasitol. 2018 Mar 9. pii: S0020-7519(18)30056-0. doi: 10.1016/j.ijpara.2018.01.005. [Epub ahead of print].

A Dominant Negative Antisense Approach Targeting β-Catenin

Authors:
Vonbrüll M, Riegel E, Halter C, Aigner M, Bock H, Werner B, Lindhorst T, Czerny T
Citation:
Mol Biotechnol. 2018 Mar 9. doi: 10.1007/s12033-018-0058-7. [Epub ahead of print]
Epub:
Yes
Abstract:
There have been many attempts to unveil the therapeutic potential of antisense molecules during the last decade. Due to its...
Link:
https://link.springer.com/article/10.1007%2Fs12033-018-0058-7
Delivery Method:
cell scraping, electroporation
Organism or Cell Type:
cell culture: SW480, HeLa pSplice3βcat Ex13 SD
Citation Extract:
Vonbrüll M, Riegel E, Halter C, Aigner M, Bock H, Werner B, Lindhorst T, Czerny T. A Dominant Negative Antisense Approach Targeting β-Catenin. Mol Biotechnol. 2018 Mar 9. doi: 10.1007/s12033-018-0058-7. [Epub ahead of print].

C9orf72 is essential for neurodevelopment and motility mediated by cyclin G1

Authors:
Yeh TH, Liu HF, Li YW, Lu CS, Shih HY, Chiu CC, Lin SJ, Huang YC, Cheng YC
Citation:
Exp Neurol. 2018 Mar 6. pii: S0014-4886(18)30064-5. doi: 10.1016/j.expneurol.2018.03.002. [Epub ahead of print]
Epub:
Yes
Abstract:
Hexanucleotide repeat expansions in the C9orf72 gene are a common genetic cause of familial and sporadic amyotrophic lateral...
Link:
https://www.sciencedirect.com/science/article/pii/S0014488618300645
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yeh TH, Liu HF, Li YW, Lu CS, Shih HY, Chiu CC, Lin SJ, Huang YC, Cheng YC. C9orf72 is essential for neurodevelopment and motility mediated by cyclin G1. Exp Neurol. 2018 Mar 6. pii: S0014-4886(18)30064-5. doi: 10.1016/j.expneurol.2018.03.002. [Epub ahead of print].

Song X, Gao X, Lu J, Liang H, Su P, Li Q, Pang Y

Authors:
High mobility group box transcription factor 1 (HBP1) from Lampetra japonica affects cell cycle regulation
Citation:
Develop Growth Differ. 2018;[Epub] doi:10.1111/dgd.12426
Epub:
Yes
Abstract:
High mobility group (HMG) box-containing protein 1 (HBP1) is a member of the HMG family of chromosomal proteins. Previous...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/dgd.12426/abstract
Organism or Cell Type:
cell culture: Lampetra japonica cells
Citation Extract:
High mobility group box transcription factor 1 (HBP1) from Lampetra japonica affects cell cycle regulation. Song X, Gao X, Lu J, Liang H, Su P, Li Q, Pang Y. Develop Growth Differ. 2018;[Epub] doi:10.1111/dgd.12426.

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