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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish
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Citation:
Elife. 2015 Oct 16;4. pii: e09406. doi: 10.7554/eLife.09406 Epub:
Not Epub Abstract:
Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy and skeletal myopathy. The most... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16;4. pii: e09406. doi: 10.7554/eLife.09406. |
RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure
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Citation:
J Clin Invest. 2015 Nov 30. pii: 84015. doi: 10.1172/JCI84015. [Epub ahead of print] Epub:
Yes Abstract:
RNA splicing is a major contributor to total transcriptome complexity; however, the functional role and regulation of splicing... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gao C, Ren S, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, Xiao X, Fu XD, Chen JN, Wang Y. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. J Clin Invest. 2015 Nov 30. pii: 84015. doi: 10.1172/JCI84015. [Epub ahead of print]. |
Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish
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Citation:
Development 2015 142: 4080-4091; doi: 10.1242/dev.125724 Epub:
Not Epub Abstract:
Congenital heart disease often features structural abnormalities that emerge during development. Accumulating evidence... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Samsa LA, Givens C, Tzima E, Stainier DYR, Qian L, Liu J. Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish. Development 2015 142: 4080-4091; doi: 10.1242/dev.125724. |
The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry
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Citation:
Development. 2015 Oct 22. pii: dev.126953. [Epub ahead of print] Epub:
Yes Abstract:
Vertebrate left-right (LR) asymmetry originates at a transient left-right organizer (LRO), where cilia play a crucial role in... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Endicott SJ, Basu B, Khokha M, Brueckner M. The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry. Development. 2015 Oct 22. pii: dev.126953. [Epub ahead of print]. |
The ascidian numb gene involves in the formation of neural tissues
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Citation:
Balsaenggwa Saengsig. 2012 Dec;16(4):371-8. doi: 10.12717/DR.2012.16.4.371 Epub:
Not Epub Abstract:
Notch signaling plays fundamental roles in various animal development. It has been suggested that Hr-Notch, a Notch homologue... Delivery Method:
microinjection Organism or Cell Type:
Halocynthia roretzi Citation Extract: Ahn HR, Kim GJ. The ascidian numb gene involves in the formation of neural tissues. Balsaenggwa Saengsig. 2012 Dec;16(4):371-8. doi: 10.12717/DR.2012.16.4.371. |
RFX7 is required for the formation of cilia in the neural tube
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Citation:
Mech Dev. 2014 May;132:28-37. doi: 10.1016/j.mod.2014.02.001. Epub 2014 Feb 12 Epub:
Not Epub Abstract:
Regulatory Factor X (RFX) transcription factors are important for development and are likely involved in the pathogenesis of... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Manojlovic Z, Earwood R, Kato A, Stefanovic B, Kato Y. RFX7 is required for the formation of cilia in the neural tube. Mech Dev. 2014 May;132:28-37. doi: 10.1016/j.mod.2014.02.001. Epub 2014 Feb 12. |
Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth
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Citation:
J Clin Invest. 2016;126(1):68-84. doi:10.1172/JCI82534 Epub:
Not Epub Abstract:
MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in... Delivery Method:
DNA-leash lipofectamine (melanoma cells), DLBCL cells electroporation (DLBCL), Vivo-Morpholino (mice) Organism or Cell Type:
cell culture MDM4-expressing melanoma cell lines, diffuse, large B cell lymphoma DLBCL cells, mice Citation Extract: Dewaele M, Tabaglio T, Willekens K, Bezzi M, Teo SX, Low DHP, Koh CM, Rambow F, Fiers M, Rogiers A, Radaelli E, Al-Haddawi M, Tan SY, Hermans E, Amant F, Yan H, Lakshmanan M, Koumar RC, Lim ST, Derheimer FA, Campbell RM, Bonday Z, Tergaonkar V, Shackleton M, Blattner C, Marine J-C, Guccione E. Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth. J Clin Invest. 2016;126(1):68-84. doi:10.1172/JCI82534. |
Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation
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Citation:
Chem Biol. 2014 Apr 24;21(4):488-501. doi: 10.1016/j.chembiol.2014.02.013. Epub 2014 Mar 27 Epub:
Not Epub Abstract:
Cranial neural crest (CNC) cells are patterned and coalesce to facial prominences that undergo convergence and extension to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kong Y, Grimaldi M, Curtin E, Dougherty M, Kaufman C, White RM, Zon LI, Liao EC. Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation. Chem Biol. 2014 Apr 24;21(4):488-501. doi: 10.1016/j.chembiol.2014.02.013. Epub 2014 Mar 27. |
Endothelial Ca2+ oscillations reflect VEGFR signaling-regulated angiogenic capacity in vivo
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Citation:
eLife. 2015;10.7554/eLife.08817 doi:10.7554/eLife.08817 Epub:
Not Epub Abstract:
Sprouting angiogenesis is a well-coordinated process controlled by multiple extracellular inputs, including vascular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yokota Y, Nakajima H, Wakayama Y, Muto A, Kawakami K, Fukuhara S, Mochizuki N. Endothelial Ca2+ oscillations reflect VEGFR signaling-regulated angiogenic capacity in vivo. eLife. 2015;10.7554/eLife.08817 doi:10.7554/eLife.08817. |
Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics
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Citation:
Sci Rep. 2015;5:17104 doi:10.1038/srep17014 Epub:
Not Epub Abstract:
There is currently an urgent need for biomarkers that can be used to monitor the efficacy of experimental therapies for... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Coenen-Stass AML, McClorey G, Manzano R, Betts CA, Blain A, Saleh AF, Gait MJ, Lochmüller H, Wood MJA, Roberts TC. Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics. Sci Rep. 2015;5:17104 doi:10.1038/srep17014. |