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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12138 scientific papers returned from the database with the search filters currently being used below.

Antisense Oligonucleotides Promote Exon Inclusion and Correct the Common c.-32-13T>G GAA Splicing Variant in Pompe Disease

Authors:
van der Wal E, Bergsma AJ, Pijnenburg JM, van der Ploeg AT, Pijnappel WWMP
Citation:
Mol Ther Nucleic Acids. 2017 Jun 16;7:90-100. doi: 10.1016/j.omtn.2017.03.001. Epub 2017 Mar 14
Epub:
Not Epub
Abstract:
The most common variant causing Pompe disease is c.-32-13T>G (IVS1) in the acid α-glucosidase (GAA) gene, which weakens the...
Link:
http://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(17)30139-7
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human primary fibroblasts
Citation Extract:
van der Wal E, Bergsma AJ, Pijnenburg JM, van der Ploeg AT, Pijnappel WWMP. Antisense Oligonucleotides Promote Exon Inclusion and Correct the Common c.-32-13T>G GAA Splicing Variant in Pompe Disease. Mol Ther Nucleic Acids. 2017 Jun 16;7:90-100. doi: 10.1016/j.omtn.2017.03.001. Epub 2017 Mar 14.

Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ<sub>1-42</sub> and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae

Authors:
Nery LR, Silva NE, Fonseca R, Vianna MRM
Citation:
Neurochem Res. 2017 Jun 16. doi: 10.1007/s11064-017-2327-4. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Presenilins are transmembrane proteases required for the proteolytic cleavage of Notch and also act as the catalytic core of...
Link:
https://link.springer.com/article/10.1007%2Fs11064-017-2327-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nery LR, Silva NE, Fonseca R, Vianna MRM. Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ<sub>1-42</sub> and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae. Neurochem Res. 2017 Jun 16. doi: 10.1007/s11064-017-2327-4. [Epub ahead of print].

Zebrafish Znfl1s control the expression of hoxb1b in the posterior neuroectoderm by acting upstream of pou5f3 and sall4

Authors:
Dong X, Li J, He L, Gu C, Jia W, Yue Y, Li J, Zhang Q, Chu L, Zhao Q
Citation:
J Biol Chem. 2017 Jun 16. pii: jbc.M117.777094. doi: 10.1074/jbc.M117.777094. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Transcription factors play crucial roles in patterning posterior neuroectoderm. Previously, zinc finger transcription factor...
Link:
http://www.jbc.org/content/early/2017/06/16/jbc.M117.777094.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dong X, Li J, He L, Gu C, Jia W, Yue Y, Li J, Zhang Q, Chu L, Zhao Q. Zebrafish Znfl1s control the expression of hoxb1b in the posterior neuroectoderm by acting upstream of pou5f3 and sall4. J Biol Chem. 2017 Jun 16. pii: jbc.M117.777094. doi: 10.1074/jbc.M117.777094. [Epub ahead of print].

FoxD1 protein interacts with Wnt and BMP signaling to differentially pattern mesoderm and neural tissue

Authors:
Polevoy H, Malyarova A, Fonar Y, Elias S, Frank D
Citation:
Int J Dev Biol. 2017;61(3-4-5):293-302. doi: 10.1387/ijdb.160300df
Epub:
Not Epub
Abstract:
The foxd1 gene (previously known as Brain Factor 2/BF2) is expressed during early Xenopus laevis development. At gastrula...
Link:
http://www.ijdb.ehu.es/web/paper/160300df/foxd1-protein-interacts-with-wnt-and-bmp-signaling-to-differentially-pattern-mesoderm-and-neural-tissue
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Polevoy H, Malyarova A, Fonar Y, Elias S, Frank D. FoxD1 protein interacts with Wnt and BMP signaling to differentially pattern mesoderm and neural tissue. Int J Dev Biol. 2017;61(3-4-5):293-302. doi: 10.1387/ijdb.160300df.

Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease

Authors:
Haskell GT, Jensen BC, Samsa LA, Marchuk D, Huang W, Skrzynia C, Tilley C, Seifert BA, Rivera-Muñoz EA, Koller B, Wilhelmsen KC, Liu J, Alhosaini H, Weck KE, Evans JP, Berg JS
Citation:
Circ Cardiovasc Genet. 2017 Jun;10(3). pii: e001443. doi: 10.1161/CIRCGENETICS.116.001443
Epub:
Not Epub
Abstract:
Recent findings indicate that growth factor-driven angiogenesis is markedly influenced by genetic variation. This variation in...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006848
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Haskell GT, Jensen BC, Samsa LA, Marchuk D, Huang W, Skrzynia C, Tilley C, Seifert BA, Rivera-Muñoz EA, Koller B, Wilhelmsen KC, Liu J, Alhosaini H, Weck KE, Evans JP, Berg JS. Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease. Circ Cardiovasc Genet. 2017 Jun;10(3). pii: e001443. doi: 10.1161/CIRCGENETICS.116.001443.

Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease

Authors:
Haskell GT, Jensen BC, Samsa LA, Marchuk D, Huang W, Skrzynia C, Tilley C, Seifert BA, Rivera-Muñoz EA, Koller B, Wilhelmsen KC, Liu J, Alhosaini H, Weck KE, Evans JP, Berg JS
Citation:
Circ Cardiovasc Genet. 2017 Jun;10(3). pii: e001443. doi: 10.1161/CIRCGENETICS.116.001443
Epub:
Yes
Abstract:
BACKGROUND: The genetic variation underlying many heritable forms of cardiovascular disease is incompletely understood, even in...
Link:
http://circgenetics.ahajournals.org/content/10/3/e001443.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Haskell GT, Jensen BC, Samsa LA, Marchuk D, Huang W, Skrzynia C, Tilley C, Seifert BA, Rivera-Muñoz EA, Koller B, Wilhelmsen KC, Liu J, Alhosaini H, Weck KE, Evans JP, Berg JS. Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease. Circ Cardiovasc Genet. 2017 Jun;10(3). pii: e001443. doi: 10.1161/CIRCGENETICS.116.001443.

Targeted gene knockdown validates the essential role of lactate dehydrogenase in Cryptosporidium parvum

Authors:
Witola WH, Zhang X, Kim CY
Citation:
Int J Parasitol. 2017 Jun 9. pii: S0020-7519(17)30166-2. doi: 10.1016/j.ijpara.2017.05.002. [Epub ahead of print]
Epub:
Yes
Abstract:
Cryptosporidium parvum is a zoonotic protozoan that can cause a life-threatening gastrointestinal syndrome in children and in...
Link:
http://www.sciencedirect.com/science/article/pii/S0020751917301662
Delivery Method:
Vivo-Morpholino, Endo-Porter
Organism or Cell Type:
Cryptosporidium parvum
Citation Extract:
Witola WH, Zhang X, Kim CY. Targeted gene knockdown validates the essential role of lactate dehydrogenase in Cryptosporidium parvum. Int J Parasitol. 2017 Jun 9. pii: S0020-7519(17)30166-2. doi: 10.1016/j.ijpara.2017.05.002. [Epub ahead of print].

Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2-/- mice

Authors:
Hall C, Ehrlich L, Meng F, Invernizzi P, Bernuzzi F, Lairmore TC, Alpini G, Glaser S
Citation:
J Surg Res. 2017 May 11. pii: S0022-4804(17)30273-1. doi: 10.1016/j.jss.2017.05.020. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Liver transplantation remains the primary treatment for primary sclerosing cholangitis (PSC). Mdr2-/- mice provide...
Link:
http://www.journalofsurgicalresearch.com/article/S0022-4804(17)30273-1/fulltext
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice Mdr2-/-
Citation Extract:
Hall C, Ehrlich L, Meng F, Invernizzi P, Bernuzzi F, Lairmore TC, Alpini G, Glaser S. Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2-/- mice. J Surg Res. 2017 May 11. pii: S0022-4804(17)30273-1. doi: 10.1016/j.jss.2017.05.020. [Epub ahead of print].

Cationic Cytosine Morpholino-Based Transporters: Synthesis and Regulation of Intracellular Localization

Authors:
Nandi B, Khatra H, Khan PP, Bhadra J, Pattanayak S, Sinha S.
Citation:
ChemistrySelect. 2017;2:5059-67 doi:10.1002/slct.201700238
Epub:
Not Epub
Abstract:
Cationic guanidinium and phosphonium functionalized cytosine morpholino tetramer (G3) and trimer (P3) have been reported for...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/slct.201700238/abstract
Delivery Method:
modified cationic cytosine moieties
Organism or Cell Type:
zebrafish
Citation Extract:
Nandi B, Khatra H, Khan PP, Bhadra J, Pattanayak S, Sinha S.. Cationic Cytosine Morpholino-Based Transporters: Synthesis and Regulation of Intracellular Localization. ChemistrySelect. 2017;2:5059-67 doi:10.1002/slct.201700238.

Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes

Authors:
Drew K, Lee C, Huizar RL, Tu F, Borgeson B, McWhite CD, Ma Y, Wallingford JB, Marcotte EM
Citation:
Mol Syst Biol. 2017 Jun 8;13(6):932. doi: 10.15252/msb.20167490
Epub:
Yes
Abstract:
Macromolecular protein complexes carry out many of the essential functions of cells, and many genetic diseases arise from...
Link:
http://msb.embopress.org/content/13/6/932
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Drew K, Lee C, Huizar RL, Tu F, Borgeson B, McWhite CD, Ma Y, Wallingford JB, Marcotte EM. Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes. Mol Syst Biol. 2017 Jun 8;13(6):932. doi: 10.15252/msb.20167490.

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