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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient

Authors:
Nakamura A, Aoki Y, Tsoumpra M, Yokota T, Takeda S
Citation:
Methods Mol Biol. 2018;1828:151-163. doi: 10.1007/978-1-4939-8651-4_9
Epub:
Not Epub
Abstract:
Antisense oligonucleotide induced exon skipping emerges as a promising therapeutic strategy for patients suffering from a...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_9
Organism or Cell Type:
cell culture: canine and human fibroblasts differentiated to myotubes
Citation Extract:
Nakamura A, Aoki Y, Tsoumpra M, Yokota T, Takeda S. In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient. Methods Mol Biol. 2018;1828:151-163. doi: 10.1007/978-1-4939-8651-4_9.

Tips to Design Effective Splice-Switching Antisense Oligonucleotides for Exon Skipping and Exon Inclusion

Authors:
Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2018;1828:79-90. doi: 10.1007/978-1-4939-8651-4_5
Epub:
Not Epub
Abstract:
Antisense-mediated exon skipping and exon inclusion have proven to be powerful tools for treating neuromuscular diseases. The...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_5
Citation Extract:
Maruyama R, Yokota T. Tips to Design Effective Splice-Switching Antisense Oligonucleotides for Exon Skipping and Exon Inclusion. Methods Mol Biol. 2018;1828:79-90. doi: 10.1007/978-1-4939-8651-4_5.

Bapx1 is required for jaw joint development in amphibians

Authors:
Lukas P, Olsson L.
Citation:
Evol Dev. 2018 Nov;20(6):192-206. doi:10.1111/ede.12267
Epub:
Not Epub
Abstract:
The acquisition of a movable jaw and a jaw joint are key events in gnathostome evolution. Jaws are derived from the neural...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1111/ede.12267
Citation Extract:
Lukas P, Olsson L. . Bapx1 is required for jaw joint development in amphibians. Evol Dev. 2018 Nov;20(6):192-206. doi:10.1111/ede.12267.

Pressure-Modulated Selective Electrokinetic Trapping for Direct Enrichment, Purification, and Detection of Nucleic Acids in Human Serum

Authors:
Ouyang W, Li Z, Han J
Citation:
Anal Chem. 2018 Aug 29. doi: 10.1021/acs.analchem.8b02330. [Epub ahead of print]
Epub:
Yes
Abstract:
Micro total analysis systems (μTAS) have been extensively developed for the detection of nucleic acids (NAs) in resource-...
Link:
https://pubs.acs.org/doi/10.1021/acs.analchem.8b02330
Citation Extract:
Ouyang W, Li Z, Han J. Pressure-Modulated Selective Electrokinetic Trapping for Direct Enrichment, Purification, and Detection of Nucleic Acids in Human Serum. Anal Chem. 2018 Aug 29. doi: 10.1021/acs.analchem.8b02330. [Epub ahead of print].

Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

Authors:
Li L, Jiao X, D’Atri I, Ono F, Nelson R, Chan C-C, Nakaya N, Ma Z, Ma Y, Cai X, Zhang L, Lin S, Hameed A, Chioza BA, Hardy H, Arno G, Hull S, Khan MI, Fasham J, Harlalka GV, Michaelides M, Moore AT, Akdemir ZHC, Jhangiani S, Lupski JR, Cremers FPM, Qamar R, Salman A, Chilton J, Self J, Ayyagari R, Firoz Kabir F, Naeem MA, Ali M, Akram J, Sieving PA, Riazuddin S, Baple EL, Riazuddin SA, Crosby AH, Hejtmancik JF
Citation:
PLoS Genet. 2018;14(8):e1007504. doi:10.1371/journal.pgen.1007504
Epub:
Not Epub
Abstract:
We identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding a presumptive intracellular chloride...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1007504
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li L, Jiao X, D’Atri I, Ono F, Nelson R, Chan C-C, Nakaya N, Ma Z, Ma Y, Cai X, Zhang L, Lin S, Hameed A, Chioza BA, Hardy H, Arno G, Hull S, Khan MI, Fasham J, Harlalka GV, Michaelides M, Moore AT, Akdemir ZHC, Jhangiani S, Lupski JR, Cremers FPM, Qamar R, Salman A, Chilton J, Self J, Ayyagari R, Firoz Kabir F, Naeem MA, Ali M, Akram J, Sieving PA, Riazuddin S, Baple EL, Riazuddin SA, Crosby AH, Hejtmancik JF. Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. PLoS Genet. 2018;14(8):e1007504. doi:10.1371/journal.pgen.1007504.

TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration

Authors:
Yoon J, Hwang Y-S, Lee M, Sun J, Cho HJ, Knapik L, Daar IO
Citation:
Nat Comm. 2018;9:3491. doi:10.1038/s41467-018-05924-9
Epub:
Not Epub
Abstract:
Although Eph-ephrin signalling has been implicated in the migration of cranial neural crest (CNC) cells, it is still unclear...
Link:
https://www.nature.com/articles/s41467-018-05924-9
Organism or Cell Type:
Xenopus
Citation Extract:
Yoon J, Hwang Y-S, Lee M, Sun J, Cho HJ, Knapik L, Daar IO. TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration. Nat Comm. 2018;9:3491. doi:10.1038/s41467-018-05924-9.

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia

Authors:
Lee S-H, Singh I, Tisdale S, Abdel-Wahab O, Leslie CS, Mayr C
Citation:
Nature. 2018:[Epub ahead of print] doi:10.1038/s41586-018-0465-8DO
Epub:
Yes
Abstract:
DNA mutations are known cancer drivers. Here we investigated whether mRNA events that are upregulated in cancer can...
Link:
https://www.nature.com/articles/s41586-018-0465-8
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Lee S-H, Singh I, Tisdale S, Abdel-Wahab O, Leslie CS, Mayr C. Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia. Nature. 2018:[Epub ahead of print] doi:10.1038/s41586-018-0465-8DO.

De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome

Authors:
Toki T, Yoshida K, Wang R, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F, Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa Y, Kataoka K, Shiraishi Y, Sanada M, Chiba K, Tanaka H, Terui K, Sato T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Kanno H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto K, Ogawa S, Ito E
Citation:
Am J Hum Genet. 2018 Aug 22. pii: S0002-9297(18)30247-7. doi: 10.1016/j.ajhg.2018.07.020. [Epub ahead of print]
Epub:
Yes
Abstract:
Inherited bone-marrow-failure syndromes (IBMFSs) include heterogeneous genetic disorders characterized by bone-marrow failure,...
Link:
https://www.sciencedirect.com/science/article/pii/S0002929718302477
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Toki T, Yoshida K, Wang R, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F, Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa Y, Kataoka K, Shiraishi Y, Sanada M, Chiba K, Tanaka H, Terui K, Sato T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Kanno H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto K, Ogawa S, Ito E. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome. Am J Hum Genet. 2018 Aug 22. pii: S0002-9297(18)30247-7. doi: 10.1016/j.ajhg.2018.07.020. [Epub ahead of print].

Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality

Authors:
Saydmohammed M, Yagi H, Calderon M, Clark MJ, Feinstein T, Sun M, Stolz DB, Watkins SC, Amack JD, Lo CW, Tsang M
Citation:
Nat Commun. 2018 Aug 23;9(1):3381. doi: 10.1038/s41467-018-05866-2
Epub:
Not Epub
Abstract:
Establishing left-right asymmetry is a fundamental process essential for arrangement of visceral organs during development. In...
Link:
https://www.nature.com/articles/s41467-018-05866-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Saydmohammed M, Yagi H, Calderon M, Clark MJ, Feinstein T, Sun M, Stolz DB, Watkins SC, Amack JD, Lo CW, Tsang M. Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality. Nat Commun. 2018 Aug 23;9(1):3381. doi: 10.1038/s41467-018-05866-2.

A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural crest cells

Authors:
Buitrago-Delgado E, Schock EN, Nordin K, LaBonne C
Citation:
Dev Biol. 2018 Aug 22. pii: S0012-1606(18)30259-8. doi: 10.1016/j.ydbio.2018.08.008. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The neural crest is a stem cell population unique to vertebrate embryos that gives rise to derivatives from multiple embryonic...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160618302598
Organism or Cell Type:
Xenopus
Citation Extract:
Buitrago-Delgado E, Schock EN, Nordin K, LaBonne C. A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural crest cells. Dev Biol. 2018 Aug 22. pii: S0012-1606(18)30259-8. doi: 10.1016/j.ydbio.2018.08.008. [Epub ahead of print].

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