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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal
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Citation:
Cell Rep. 2019;28(9):2264-74. doi:10.1016/j.celrep.2019.07.087 Epub:
Not Epub Abstract:
Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Di Bella DJ, Carcagno AL, Bartolomeu ML, Pardi MB, Löhr H, Siegel N, Hammerschmidt M, Marín-Burgin A, Lanuza GM. Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal. Cell Rep. 2019;28(9):2264-74. doi:10.1016/j.celrep.2019.07.087. |
Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy
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Citation:
Biochemistry. 2019 Sep 24;58(38):3980-3989. doi: 10.1021/acs.biochem.9b00413. Epub 2019 Sep 6. PMID: 31450889 Epub:
Yes Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) make up a promising class of therapeutics for genetic disease. PMOs... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa-654 Citation Extract: Fadzen CM, Holden RL, Wolfe JM, Choo ZN, Schissel CK, Yao M, Hanson GJ, Pentelute BL. Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy. Biochemistry. 2019 Sep 24;58(38):3980-3989. doi: 10.1021/acs.biochem.9b00413. Epub 2019 Sep 6. PMID: 31450889. |
Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation
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Citation:
Development. 2019 Aug 23. pii: dev.177063. doi: 10.1242/dev.177063. [Epub ahead of print] Epub:
Yes Abstract:
The presumptive somite boundary in the presomitic mesoderm (PSM) is defined by the anterior border of the expression domain of... Organism or Cell Type:
zebrafish Citation Extract: Ban H, Yokota D, Otosaka S, Kikuchi M, Kinoshita H, Fujino Y, Yabe T, Ovara H, Izuka A, Akama K, Yamasu K, Takada S, Kawamura A.. Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation. Development. 2019 Aug 23. pii: dev.177063. doi: 10.1242/dev.177063. [Epub ahead of print]. |
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates
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Citation:
Nat Comm. 2019;10(1):3857. doi:10.1038/s41467-019-11561-7 Epub:
Not Epub Abstract:
Cardiovascular lineages develop together with kidney, smooth muscle, and limb connective tissue progenitors from the lateral... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Prummel KD, Hess C, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Anna Czarkwiani, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, Müller P, Bronner M, Krumlauf R, Mosimann C. A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nat Comm. 2019;10(1):3857. doi:10.1038/s41467-019-11561-7. |
Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation
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Citation:
Biology. 2019;8(3):61. doi:10.3390/biology8030061 Epub:
Not Epub Abstract:
Homologous long non-coding RNAs (lncRNAs) are elusive to identify by sequence similarity due to their fast-evolutionary rate.... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Herrera-Úbeda C, Marín-Barba M, Navas-Pérez E, Gravemeyer J, Albuixech-Crespo BA, Wheeler GN, Garcia-Fernàndez J. Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation. Biology. 2019;8(3):61. doi:10.3390/biology8030061. |
Functional role of pax6 during eye and nervous system development in the annelid Capitella teleta
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Citation:
Dev Biol. 2019 Aug 21. pii: S0012-1606(18)30055-1. doi: 10.1016/j.ydbio.2019.08.011. [Epub ahead of print] Epub:
Yes Abstract:
The transcription factor Pax6 is an important regulator of early animal development. Loss of function mutations of pax6 in a... Delivery Method:
microinjection Organism or Cell Type:
Capitella teleta (annelid) Citation Extract: Klann M, Seaver EC. Functional role of pax6 during eye and nervous system development in the annelid Capitella teleta. Dev Biol. 2019 Aug 21. pii: S0012-1606(18)30055-1. doi: 10.1016/j.ydbio.2019.08.011. [Epub ahead of print]. |
Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy
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Citation:
bioRxiv. 2019;[preprint] doi:10.1101/744144 Epub:
Not Epub Abstract:
The contribution of microglia in neurological disorders is emerging as a leading driver rather than a consequence of pathology... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Hamilton N, Rutherford HA, Isles HM, Petts JJ, Henneke M, Gaertner J, Dunning M, Renshaw SA. Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy. bioRxiv. 2019;[preprint] doi:10.1101/744144. |
Chemokine signaling links cell-cycle progression and cilia formation for left–right symmetry breaking
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Citation:
PLoS Biol. 2019;17(8):e3000203. doi:10.1371/journal.pbio.3000203 Epub:
Not Epub Abstract:
Zebrafish dorsal forerunner cells (DFCs) undergo vigorous proliferation during epiboly and then exit the cell cycle to generate... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Liu J, Zhu C, Ning G, Yang L, Cao Y, Huang S, Wang Q. Chemokine signaling links cell-cycle progression and cilia formation for left–right symmetry breaking. PLoS Biol. 2019;17(8):e3000203. doi:10.1371/journal.pbio.3000203. |
Genome-wide identification of binding sites and gene targets of Alx1, a pivotal regulator of echinoderm skeletogenesis
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Citation:
Development. 2019;146:dev180653. doi: 10.1242/dev.180653 Epub:
Not Epub Abstract:
Alx1 is a conserved regulator of skeletogenesis in echinoderms and evolutionary changes in Alx1 sequence and expression have... Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin) Citation Extract: Khor JM, Guerrero-Santoro J, Ettensohn CA. Genome-wide identification of binding sites and gene targets of Alx1, a pivotal regulator of echinoderm skeletogenesis. Development. 2019;146:dev180653. doi: 10.1242/dev.180653. |
Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins
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Citation:
Nat Comm. 2019;10(1):3779. doi:10.1038/s41467-019-11560-8 Epub:
Not Epub Abstract:
Evolution is proposed to result, in part, from acquisition of new developmental programs. One such example is the appearance of... Delivery Method:
microinjection Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin) Citation Extract: Poon J, Fries A, Wessel GM, Yajima M. Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins. Nat Comm. 2019;10(1):3779. doi:10.1038/s41467-019-11560-8. |