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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

DNA methylation analysis of Homeobox genes implicates HOXB7 hypomethylation as risk factor for neural tube defects

Authors:
Rochtus A, Izzi B, Vangeel E, Louwette S, Wittevrongel C, Lambrechts D, Moreau Y, Winand R, Verpoorten C, Jansen K, Van Geet C, Freson K
Citation:
Epigenetics. 2015;10(1):92-101. doi: 10.1080/15592294.2014.998531. Epub 2015 Jan 29
Epub:
Not Epub
Abstract:
Neural tube defects (NTDs) are common birth defects of complex etiology. Though family- and population-based studies have...
Link:
http://www.tandfonline.com/doi/full/10.1080/15592294.2014.998531
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rochtus A, Izzi B, Vangeel E, Louwette S, Wittevrongel C, Lambrechts D, Moreau Y, Winand R, Verpoorten C, Jansen K, Van Geet C, Freson K. DNA methylation analysis of Homeobox genes implicates HOXB7 hypomethylation as risk factor for neural tube defects. Epigenetics. 2015;10(1):92-101. doi: 10.1080/15592294.2014.998531. Epub 2015 Jan 29.

Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition

Authors:
Qian Y, van Meel E, Flanagan-Steet H, Yox A, Steet R, Kornfeld S
Citation:
J Biol Chem. 2015 Jan 30;290(5):3045-56. doi: 10.1074/jbc.M114.612507. Epub 2014 Dec 11
Epub:
Not Epub
Abstract:
UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase tags newly synthesized lysosomal enzymes with mannose 6-phosphate...
Link:
http://www.jbc.org/content/290/5/3045.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Qian Y, van Meel E, Flanagan-Steet H, Yox A, Steet R, Kornfeld S. Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition. J Biol Chem. 2015 Jan 30;290(5):3045-56. doi: 10.1074/jbc.M114.612507. Epub 2014 Dec 11.

Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish

Authors:
Ge R, Zhou Y, Peng R, Wang R, Li M, Zhang Y, Zheng C, Wang C
Citation:
J Virol. 2015 Aug;89(15):7696-706. doi: 10.1128/JVI.01049-15. Epub 2015 May 13
Epub:
Not Epub
Abstract:
Zebrafish (Danio rerio) is a unique potential model animal for dissecting innate immune signaling. Here we demonstrate that...
Link:
http://jvi.asm.org/content/89/15/7696.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ge R, Zhou Y, Peng R, Wang R, Li M, Zhang Y, Zheng C, Wang C. Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish. J Virol. 2015 Aug;89(15):7696-706. doi: 10.1128/JVI.01049-15. Epub 2015 May 13.

Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease

Authors:
Levic DS, Minkel JR, Wang WD, Rybski WM, Melville DB, Knapik EW
Citation:
J Mol Med (Berl). 2015 Feb;93(2):165-76. doi: 10.1007/s00109-014-1247-x. Epub 2015 Jan 7
Epub:
Not Epub
Abstract:
Anderson disease (ANDD) or chylomicron retention disease (CMRD) is a rare, hereditary lipid malabsorption syndrome associated...
Link:
http://link.springer.com/article/10.1007%2Fs00109-014-1247-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Levic DS, Minkel JR, Wang WD, Rybski WM, Melville DB, Knapik EW. Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease. J Mol Med (Berl). 2015 Feb;93(2):165-76. doi: 10.1007/s00109-014-1247-x. Epub 2015 Jan 7.

FAT1 mutations cause a glomerulotubular nephropathy

Authors:
Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LGT, ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NES, Walz G, Tufro A, Hildebrandt F
Citation:
Nat Comm. 2016;7:10822 doi:10.1038/ncomms10822
Epub:
Not Epub
Abstract:
Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease (CKD). Here we show that recessive mutations...
Link:
http://www.nature.com/ncomms/2016/160224/ncomms10822/full/ncomms10822.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LGT, ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NES, Walz G, Tufro A, Hildebrandt F. FAT1 mutations cause a glomerulotubular nephropathy. Nat Comm. 2016;7:10822 doi:10.1038/ncomms10822.

foxc1a genetically interacts with ripply1 to regulate mesp-ba expression and somitogenesis in the zebrafish embryo

Authors:
Lavy R, Allison WT, Berry FB
Citation:
bioRxiv. 2016;preprint. doi:10.1101/041012
Epub:
Not Epub
Abstract:
Somitogenesis is a fundamental segmentation process that forms the vertebrate body plan. A network of transcription factors is...
Link:
http://biorxiv.org/content/early/2016/02/23/041012
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lavy R, Allison WT, Berry FB. foxc1a genetically interacts with ripply1 to regulate mesp-ba expression and somitogenesis in the zebrafish embryo. bioRxiv. 2016;preprint. doi:10.1101/041012.

Tumor protein Tctp regulates axon development in the embryonic visual system

Authors:
Roque CG, Wong HH, Lin JQ, Holt CE
Citation:
Development. 2016 Feb 22. pii: dev.131060. [Epub ahead of print]
Epub:
Yes
Abstract:
The transcript encoding translationally controlled tumor protein (Tctp), a molecule correlated with aggressive breast cancers,...
Link:
http://dev.biologists.org/content/early/2016/02/22/dev.131060
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Roque CG, Wong HH, Lin JQ, Holt CE. Tumor protein Tctp regulates axon development in the embryonic visual system. Development. 2016 Feb 22. pii: dev.131060. [Epub ahead of print].

mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish

Authors:
Koltowska K, Paterson S, Bower NI, Baillie GJ, Lagendijk AK, Astin JW, Chen H, Francois M, Crosier PS, Taft RJ, Simons C, Smith KA, Hogan BM
Citation:
Genes Dev. 2015 Aug 1;29(15):1618-30. doi: 10.1101/gad.263210.115
Epub:
Not Epub
Abstract:
The lymphatic vasculature plays roles in tissue fluid balance, immune cell trafficking, fatty acid absorption, cancer...
Link:
http://genesdev.cshlp.org/content/29/15/1618.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Koltowska K, Paterson S, Bower NI, Baillie GJ, Lagendijk AK, Astin JW, Chen H, Francois M, Crosier PS, Taft RJ, Simons C, Smith KA, Hogan BM. mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes Dev. 2015 Aug 1;29(15):1618-30. doi: 10.1101/gad.263210.115.

DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos

Authors:
Jacob V, Chernyavskaya Y, Chen X, Tan PS, Kent B, Hoshida Y, Sadler KC
Citation:
Development. 2015 Feb 1;142(3):510-21. doi: 10.1242/dev.115980. Epub 2015 Jan 6
Epub:
Not Epub
Abstract:
UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication and...
Link:
http://dev.biologists.org/content/142/3/510.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jacob V, Chernyavskaya Y, Chen X, Tan PS, Kent B, Hoshida Y, Sadler KC. DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development. 2015 Feb 1;142(3):510-21. doi: 10.1242/dev.115980. Epub 2015 Jan 6.

Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development

Authors:
Yan B, Neilson KM, Ranganathan R, Maynard T, Streit A, Moody SA
Citation:
Dev Dyn. 2015 Feb;244(2):181-210. doi: 10.1002/dvdy.24229. Epub 2014 Dec 16
Epub:
Not Epub
Abstract:
BACKGROUND: Six1 plays an important role in the development of several vertebrate organs, including cranial sensory placodes,...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24229/abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Yan B, Neilson KM, Ranganathan R, Maynard T, Streit A, Moody SA. Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development. Dev Dyn. 2015 Feb;244(2):181-210. doi: 10.1002/dvdy.24229. Epub 2014 Dec 16.

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