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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish

Authors:
Yan C, Huo X, Wang S, Feng Y, Gong Z
Citation:
J Hepatol. 2015 Aug;63(2):420-8. doi: 10.1016/j.jhep.2015.03.024. Epub 2015 Mar 28
Epub:
Not Epub
Abstract:
Background & aims: Chronic inflammation is a major etiological factor for hepatocellular carcinoma (HCC), but how immune...
Link:
https://www.journal-of-hepatology.eu/article/S0168-8278(15)00207-X/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yan C, Huo X, Wang S, Feng Y, Gong Z. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol. 2015 Aug;63(2):420-8. doi: 10.1016/j.jhep.2015.03.024. Epub 2015 Mar 28.

Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation

Authors:
Bernut A, Loynes CA, Floto RA, Renshaw SA
Citation:
Front Immunol. 2020;11:1733 doi:10.3389/fimmu.2020.01733
Epub:
Not Epub
Abstract:
Inflammation-related progressive lung destruction is the leading causes of premature death in cystic fibrosis (CF), a genetic...
Link:
https://www.frontiersin.org/article/10.3389/fimmu.2020.01733
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bernut A, Loynes CA, Floto RA, Renshaw SA. Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Front Immunol. 2020;11:1733 doi:10.3389/fimmu.2020.01733.

Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish

Authors:
Hu Y-X, Zhu R-F, Qin Y-W, Zhao X-X, Jing Q
Citation:
Atherosclerosis. 2020 Aug 2;309:56-64. doi: 10.1016/j.atherosclerosis.2020.07.021.
Epub:
Not Epub
Abstract:
Background and aim: Angiogenesis is a key process for establishing functional vasculature during embryogenesis and involves...
Link:
https://www.atherosclerosis-journal.com/article/S0021-9150(20)30403-2/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hu Y-X, Zhu R-F, Qin Y-W, Zhao X-X, Jing Q. Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish. Atherosclerosis. 2020 Aug 2;309:56-64. doi: 10.1016/j.atherosclerosis.2020.07.021. .

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

Authors:
Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML
Citation:
Mol Ther Nucleic Acids. 2020 Jun 27;21:623-635. doi: 10.1016/j.omtn.2020.06.027. Online ahead of print
Epub:
Not Epub
Abstract:
Parkinson's disease (PD) is a progressive neurological disorder estimated to affect 7-10 million people worldwide. There...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30188-8
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: patient-derived fibroblasts
Citation Extract:
Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML. Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice. Mol Ther Nucleic Acids. 2020 Jun 27;21:623-635. doi: 10.1016/j.omtn.2020.06.027. Online ahead of print.

Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms

Authors:
Gao X, Huang SS, Qiu SW, Su Y, Wang WQ, Xu HY, Xu JC, Kang DY, Dai P, Yuan YY
Citation:
J Med Genet. 2020 Jul 31:jmedgenet-2020-106892. doi: 10.1136/jmedgenet-2020-106892. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Germline variants in PTPN11 are the primary cause of Noonan syndrome with multiple lentigines (NSML) and Noonan...
Link:
https://jmg.bmj.com/content/early/2020/07/31/jmedgenet-2020-106892
Organism or Cell Type:
zebrafish
Citation Extract:
Gao X, Huang SS, Qiu SW, Su Y, Wang WQ, Xu HY, Xu JC, Kang DY, Dai P, Yuan YY. Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms. J Med Genet. 2020 Jul 31:jmedgenet-2020-106892. doi: 10.1136/jmedgenet-2020-106892. Online ahead of print.

Assessment of Vascular Patterning in the Zebrafish

Authors:
Stratman AN, Weinstein BM
Citation:
Methods Mol Biol. 2021;2206:205-222. doi: 10.1007/978-1-0716-0916-3_15
Epub:
Not Epub
Abstract:
The zebrafish has emerged as a valuable and important model organism for studying vascular development and vascular biology....
Link:
https://link.springer.com/protocol/10.1007%2F978-1-0716-0916-3_15
Organism or Cell Type:
zebrafish
Citation Extract:
Stratman AN, Weinstein BM. Assessment of Vascular Patterning in the Zebrafish. Methods Mol Biol. 2021;2206:205-222. doi: 10.1007/978-1-0716-0916-3_15.

Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS

Authors:
Tingaud-Sequeira A, Trimouille A, Marlin S, Lopez E, Berenguer M, Gherbi S, Arveiler B, Lacombe D, Rooryck C
Citation:
Mol Genet Genomic Med. 2020 Aug 1:e1375. doi: 10.1002/mgg3.1375. Online ahead of print
Epub:
Not Epub
Abstract:
Background: The Oculo-Auriculo-Vertebral Spectrum (OAVS) or Goldenhar Syndrome is an embryonic developmental disorder...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/mgg3.1375
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tingaud-Sequeira A, Trimouille A, Marlin S, Lopez E, Berenguer M, Gherbi S, Arveiler B, Lacombe D, Rooryck C. Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS. Mol Genet Genomic Med. 2020 Aug 1:e1375. doi: 10.1002/mgg3.1375. Online ahead of print.

Rare heterozygous GDF6 variants in patients with renal anomalies

Authors:
Martens H, Hennies I, Getwan M, Christians A, Weiss A-C, Brand F, Gjerstad AC, Christians A, Gucev Z, Geffers R, Seeman T, Kispert A, Tasic V, Bjerre A, Lienkamp SS, Haffner D, Weber RG
Citation:
Eur J Hum Genet. 2020;[Epub ahead of print] doi:10.1038/s41431-020-0678-9
Epub:
Yes
Abstract:
Although over 50 genes are known to cause renal malformation if mutated, the underlying genetic basis, most easily identified...
Link:
https://www.nature.com/articles/s41431-020-0678-9
Delivery Method:
injection into stage 39 tadpoles
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Martens H, Hennies I, Getwan M, Christians A, Weiss A-C, Brand F, Gjerstad AC, Christians A, Gucev Z, Geffers R, Seeman T, Kispert A, Tasic V, Bjerre A, Lienkamp SS, Haffner D, Weber RG. Rare heterozygous GDF6 variants in patients with renal anomalies. Eur J Hum Genet. 2020;[Epub ahead of print] doi:10.1038/s41431-020-0678-9.

New roles for Nanos in neural cell fate determination revealed by studies in a cnidarian

Authors:
Kanska J, Frank U
Citation:
J Cell Sci. 2013 Jul 15;126(Pt 14):3192-203. doi: 10.1242/jcs.127233. Epub 2013 May 9
Epub:
Not Epub
Abstract:
Nanos is a pan-metazoan germline marker, important for germ cell development and maintenance. In flies, Nanos also acts in...
Link:
https://jcs.biologists.org/content/126/14/3192
Delivery Method:
microinjection
Organism or Cell Type:
Hydractinia echinata (cnidarian)
Citation Extract:
Kanska J, Frank U. New roles for Nanos in neural cell fate determination revealed by studies in a cnidarian. J Cell Sci. 2013 Jul 15;126(Pt 14):3192-203. doi: 10.1242/jcs.127233. Epub 2013 May 9.

Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site

Authors:
Smith SJ, Towers N, Demetriou K, Mohun TJ
Citation:
PLoS One. 2020 Jul 29;15(7):e0235433. doi: 10.1371/journal.pone.0235433. eCollection 2020
Epub:
Not Epub
Abstract:
ADP-ribosylhydrolase-like 1 (Adprhl1) is a pseudoenzyme expressed in the developing heart myocardium of all vertebrates. In the...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235433
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Smith SJ, Towers N, Demetriou K, Mohun TJ. Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site. PLoS One. 2020 Jul 29;15(7):e0235433. doi: 10.1371/journal.pone.0235433. eCollection 2020.

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