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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation

Authors:
Tuazon FB, Wang X, Andrade JL, Umulis D, Mullins MC
Citation:
Cell Rep. 2020;32(7):108039. doi:10.1016/j.celrep.2020.108039
Epub:
Not Epub
Abstract:
A fundamental question in developmental biology is how morphogens, such as bone morphogenetic protein (BMP), form precise...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31024-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tuazon FB, Wang X, Andrade JL, Umulis D, Mullins MC. Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation. Cell Rep. 2020;32(7):108039. doi:10.1016/j.celrep.2020.108039.

In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy

Authors:
Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li Y, Liu L, Huang J, Liu L, Peng C, Han D, Liu D, Xu K, Hu H(C)
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.17.255158
Epub:
Not Epub
Abstract:
Cerebral palsy (CP), the most prevalent physical disability in children, has long been ignored with regard to its inherent...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.17.255158v1.full.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li Y, Liu L, Huang J, Liu L, Peng C, Han D, Liu D, Xu K, Hu H(C). In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.17.255158.

Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy

Authors:
Ding Y, Yang J, Chen P, Lu T, Jiao K, Tester DJ, Giudicessi JR, Jiang K, Ackerman MJ, Li Y, Wang DW, Lee HC, Wang DW, Xu X
Citation:
J Am Heart Assoc. 2020 Aug 18:e017055. doi:10.1161/JAHA.119.017055. Online ahead of print
Epub:
Yes
Abstract:
Background Sorbs2b (sorbin and SH3 domain-containing 2b) was recently identified as a cardiomyopathy gene from a zebrafish...
Link:
https://www.ahajournals.org/doi/10.1161/JAHA.119.017055
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding Y, Yang J, Chen P, Lu T, Jiao K, Tester DJ, Giudicessi JR, Jiang K, Ackerman MJ, Li Y, Wang DW, Lee HC, Wang DW, Xu X. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. J Am Heart Assoc. 2020 Aug 18:e017055. doi:10.1161/JAHA.119.017055. Online ahead of print.

The tolerance to hypoxia is defined by a time-sensitive response of the gene regulatory network in sea urchin embryos

Authors:
Layous M, Khalaily L, Gildor T, de-Leon SB-T
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.09.242933
Epub:
Not Epub
Abstract:
Deoxygenation, the reduction of oxygen level in the oceans induced by global warming and anthropogenic disturbances, is a major...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.09.242933v2
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Layous M, Khalaily L, Gildor T, de-Leon SB-T. The tolerance to hypoxia is defined by a time-sensitive response of the gene regulatory network in sea urchin embryos. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.09.242933 .

Rab7 mediates Wnt-dependent mesoderm patterning and gastrulation in Xenopus

Authors:
Kreis J, Wielath FM, Vick P
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251298
Epub:
Not Epub
Abstract:
Early embryogenesis requires tightly controlled temporal and spatial activity of growth factors. Modulation is achieved at...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.14.251298v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kreis J, Wielath FM, Vick P. Rab7 mediates Wnt-dependent mesoderm patterning and gastrulation in Xenopus. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251298 .

A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination

Authors:
Fiuza UM, Negishi T, Rouan A, Yasuo H, Lemaire P
Citation:
Development. 2020;[Epub ahead of print]. doi: 10.1242/dev.186965
Epub:
Yes
Abstract:
Gastrulation is the first major morphogenetic event during animal embryogenesis. Ascidian gastrulation starts with the...
Link:
https://dev.biologists.org/content/147/15/dev186965
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Fiuza UM, Negishi T, Rouan A, Yasuo H, Lemaire P. A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination. Development. 2020;[Epub ahead of print]. doi: 10.1242/dev.186965.

Abortive Intussusceptive Angiogenesis Causes Multi-Cavernous Vascular Malformations

Authors:
Li W, Tran V, Shaked I, Xue B, Moore T, Lightle R, Kleinfeld D, Awad IA, Ginsberg MH
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251744
Epub:
Not Epub
Abstract:
Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.14.251744v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li W, Tran V, Shaked I, Xue B, Moore T, Lightle R, Kleinfeld D, Awad IA, Ginsberg MH. Abortive Intussusceptive Angiogenesis Causes Multi-Cavernous Vascular Malformations. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251744.

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

Authors:
Frame JM, Kubaczka C, Long TL, Esain V, Soto RA, Hachimi M, Jing R, Shwartz A, Goessling W, Daley GQ, North TE
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.07.015
Epub:
Yes
Abstract:
Embryonic hematopoietic stem and progenitor cells (HSPCs) robustly proliferate while maintaining multilineage potential in vivo...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S153458072030589X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Frame JM, Kubaczka C, Long TL, Esain V, Soto RA, Hachimi M, Jing R, Shwartz A, Goessling W, Daley GQ, North TE. Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.07.015.

De novo phosphoinositide synthesis in zebrafish is required for triad formation but not essential for myogenesis

Authors:
Smith L, Fabian L, Al-Maawali A, Noche RR, Dowling JJ
Citation:
PLoS ONE. 2020;15(8):e0231364. doi:10.1371/journal.pone.0231364
Epub:
Not Epub
Abstract:
Phosphoinositides (PIPs) and their regulatory enzymes are key players in many cellular processes and are required for aspects...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231364
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Smith L, Fabian L, Al-Maawali A, Noche RR, Dowling JJ. De novo phosphoinositide synthesis in zebrafish is required for triad formation but not essential for myogenesis. PLoS ONE. 2020;15(8):e0231364. doi:10.1371/journal.pone.0231364.

Pathogenic variants in IMPG1 cause autosomal dominant and autosomal recessive retinitis pigmentosa

Authors:
Olivier G, Corton M, Intartaglia D, Verbakel SK, Sergouniotis PI, Le Meur G, Dhaenens C-M, Naacke H, Avila-Fernández A, Hoyng CB, Klevering J, Bocquet B, Roubertie A, Sénéchal A, Banfi S, Muller A, Hamel CL, Black GC, Conte I, Roosing S, Zanlonghi X, Ayuso C, Meunier I, Manes G
Citation:
J Med Genet. 2020;[Epub ahead of print] doi: 10.1136/jmedgenet-2020-107150
Epub:
Yes
Abstract:
Background: Inherited retinal disorders are a clinically and genetically heterogeneous group of conditions and a major cause of...
Link:
https://jmg.bmj.com/content/early/2020/08/17/jmedgenet-2020-107150
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Olivier G, Corton M, Intartaglia D, Verbakel SK, Sergouniotis PI, Le Meur G, Dhaenens C-M, Naacke H, Avila-Fernández A, Hoyng CB, Klevering J, Bocquet B, Roubertie A, Sénéchal A, Banfi S, Muller A, Hamel CL, Black GC, Conte I, Roosing S, Zanlonghi X, Ayuso C, Meunier I, Manes G. Pathogenic variants in IMPG1 cause autosomal dominant and autosomal recessive retinitis pigmentosa. J Med Genet. 2020;[Epub ahead of print] doi: 10.1136/jmedgenet-2020-107150.

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