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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Gβ1 is required for neutrophil migration in zebrafish

Authors:
Ke W, Ye D, Mersch K, Xu H, Chen S, Lin F
Citation:
Dev Biol. 2017 May 26. pii: S0012-1606(16)30813-2. doi: 10.1016/j.ydbio.2017.05.024. [Epub ahead of print]
Epub:
Yes
Abstract:
Signaling mediated by G protein-coupled receptors (GPCRs) is essential for the migration of cells toward chemoattractants. The...
Link:
http://www.sciencedirect.com/science/article/pii/S0012160616308132
Organism or Cell Type:
zebrafish
Citation Extract:
Ke W, Ye D, Mersch K, Xu H, Chen S, Lin F. Gβ1 is required for neutrophil migration in zebrafish. Dev Biol. 2017 May 26. pii: S0012-1606(16)30813-2. doi: 10.1016/j.ydbio.2017.05.024. [Epub ahead of print].

Erythropoietin signaling regulates heme biosynthesis.

Authors:
Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH
Citation:
eLife. 2017;[accepted manuscript] doi:10.7554/eLife.24767
Epub:
Not Epub
Abstract:
Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions....
Link:
https://elifesciences.org/content/6/e24767
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH. Erythropoietin signaling regulates heme biosynthesis.. eLife. 2017;[accepted manuscript] doi:10.7554/eLife.24767.

Mutual Regulation of NOD2 and RIG-I in Zebrafish Provides Insights into the Coordination between Innate Antibacterial and Antiviral Signaling Pathways

Authors:
Nie L, Xu X-X, Xiang L-X, Shao J-Z, Chen J
Citation:
Int J Molec Sci. 2017;18(6):1147. doi:10.3390/ijms18061147
Epub:
Not Epub
Abstract:
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and retinoic acid-inducible gene I (RIG-I) are two...
Link:
http://www.mdpi.com/1422-0067/18/6/1147
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nie L, Xu X-X, Xiang L-X, Shao J-Z, Chen J. Mutual Regulation of NOD2 and RIG-I in Zebrafish Provides Insights into the Coordination between Innate Antibacterial and Antiviral Signaling Pathways. Int J Molec Sci. 2017;18(6):1147. doi:10.3390/ijms18061147.

Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide

Authors:
Uehara H, Muddana SK, Zhang X, Das SK, Bhuvanagiri S, Liu J, Wu Y, Choi S, Carroll LS, Archer B, Ambati BK
Citation:
Transl Vis Sci Technol. 2017 May 24;6(3):9. doi: 10.1167/tvst.6.3.9. eCollection 2017 May
Epub:
Not Epub
Abstract:
PURPOSE: We previously showed that intravitreal injection of the sFLT morpholino-oligomer (FLT-MO) suppresses laser-induced...
Link:
http://tvst.arvojournals.org/article.aspx?articleid=2629361
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: primary mouse aortic endothelial cells (MAECs), mice
Citation Extract:
Uehara H, Muddana SK, Zhang X, Das SK, Bhuvanagiri S, Liu J, Wu Y, Choi S, Carroll LS, Archer B, Ambati BK. Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide. Transl Vis Sci Technol. 2017 May 24;6(3):9. doi: 10.1167/tvst.6.3.9. eCollection 2017 May.

Knockdown of epigenetic transcriptional co-regulator Brd2a disrupts apoptosis and proper formation of hindbrain and midbrain-hindbrain boundary (MHB) region in zebrafish

Authors:
Murphy T, Melville H, Fradkin E, Bistany G, Branigan G, Olsen K, Comstock CR, Hanby H, Garbade E, DiBenedetto AJ
Citation:
Mech Dev. 2017 May 23. pii: S0925-4773(16)30065-X. doi: 10.1016/j.mod.2017.05.003. [Epub ahead of print]
Epub:
Yes
Abstract:
Brd2 is a member of the bromodomain-extraterminal domain (BET) family of proteins and functions as an acetyl-histone-directed...
Link:
http://www.sciencedirect.com/science/article/pii/S092547731630065X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Murphy T, Melville H, Fradkin E, Bistany G, Branigan G, Olsen K, Comstock CR, Hanby H, Garbade E, DiBenedetto AJ. Knockdown of epigenetic transcriptional co-regulator Brd2a disrupts apoptosis and proper formation of hindbrain and midbrain-hindbrain boundary (MHB) region in zebrafish. Mech Dev. 2017 May 23. pii: S0925-4773(16)30065-X. doi: 10.1016/j.mod.2017.05.003. [Epub ahead of print].

Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA

Authors:
Verbeeren J, Verma B, Niemelä EH, Yap K, Makeyev EV, Frilander MJ
Citation:
PLoS Genet. 2017;13(5):e1006824. doi:10.1371/journal.pgen.1006824
Epub:
Not Epub
Abstract:
Cellular homeostasis of the minor spliceosome is regulated by a negative feed-back loop that targets U11-48K and U11/U12-65K...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006824
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Verbeeren J, Verma B, Niemelä EH, Yap K, Makeyev EV, Frilander MJ. Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA. PLoS Genet. 2017;13(5):e1006824. doi:10.1371/journal.pgen.1006824.

Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues

Authors:
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A
Citation:
Cell Rep. 2017;19:1572-85. doi:10.1016/j.celrep.2017.04.078
Epub:
Not Epub
Abstract:
Motile cells navigate through complex tissue environments that include both attractive and repulsive cues. In response to...
Link:
http://www.sciencedirect.com/science/article/pii/S2211124717306125
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017;19:1572-85. doi:10.1016/j.celrep.2017.04.078.

MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling

Authors:
Li Y-W, Chiang K-Y, Li Y-H, Wu S-Y, Liu W, Lin C-R, Wu J-L
Citation:
PLoS ONE. 2017;12(5):e0177887. doi:0.1371/journal.pone.0177887
Epub:
Not Epub
Abstract:
MicroRNAs (miRs) are mRNA-regulatory molecules that fine-tune gene expression and modulate both processes of development and...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177887
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li Y-W, Chiang K-Y, Li Y-H, Wu S-Y, Liu W, Lin C-R, Wu J-L. MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling. PLoS ONE. 2017;12(5):e0177887. doi:0.1371/journal.pone.0177887.

Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy

Authors:
Vieira NM, Spinazzola JM, Alexander MS, Moreira YB, Kawahara G, Gibbs DE, Mead LC, Verjovski-Almeida S, Zatz M, Kunkel LM
Citation:
PNAS USA. 2017;[Epub ahead of print] doi: 10.1073/pnas.1703556114
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by X-linked inherited mutations in the...
Link:
http://www.pnas.org/content/early/2017/05/16/1703556114.short
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vieira NM, Spinazzola JM, Alexander MS, Moreira YB, Kawahara G, Gibbs DE, Mead LC, Verjovski-Almeida S, Zatz M, Kunkel LM. Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy. PNAS USA. 2017;[Epub ahead of print] doi: 10.1073/pnas.1703556114.

Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease

Authors:
Chen GL, Ma Q, Goswami D, Shang J, Miller GM
Citation:
J Cell Mol Med. 2017 May 19. doi: 10.1111/jcmm.13209. [Epub ahead of print]
Epub:
Yes
Abstract:
Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/jcmm.13209/abstract
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: STHdhQ7/7 and STHdhQ111/111 from transgenic humanized mice
Citation Extract:
Chen GL, Ma Q, Goswami D, Shang J, Miller GM. Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease. J Cell Mol Med. 2017 May 19. doi: 10.1111/jcmm.13209. [Epub ahead of print].

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