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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Retinoic acid regulation of the Mesp-Ripply feedback loop during vertebrate segmental patterning

Authors:
Moreno TA, Jappelli R, Izpisúa Belmonte JC, Kintner C
Citation:
Dev Biol. 2008 Mar 15;315(2):317-30. doi: 10.1016/j.ydbio.2007.12.038. Epub 2008 Jan 3
Epub:
Not Epub
Abstract:
The Mesp bHLH genes play a conserved role during segmental patterning of the mesoderm in the vertebrate embryo by specifying...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160607015965
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Moreno TA, Jappelli R, Izpisúa Belmonte JC, Kintner C. Retinoic acid regulation of the Mesp-Ripply feedback loop during vertebrate segmental patterning. Dev Biol. 2008 Mar 15;315(2):317-30. doi: 10.1016/j.ydbio.2007.12.038. Epub 2008 Jan 3.

MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation

Authors:
Bräutigam L, Zhang J, Dreij K, Spahiu L, Holmgren A, Abe H, Tew KD, Townsend DM, Kelner MJ, Morgenstern R, Johansson K
Citation:
Redox Biol. 2018;17:171-9. doi:10.1016/j.redox.2018.04.013
Epub:
Not Epub
Abstract:
We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal...
Link:
https://www.sciencedirect.com/science/article/pii/S2213231718301514
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bräutigam L, Zhang J, Dreij K, Spahiu L, Holmgren A, Abe H, Tew KD, Townsend DM, Kelner MJ, Morgenstern R, Johansson K. MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Redox Biol. 2018;17:171-9. doi:10.1016/j.redox.2018.04.013.

Lymphatic exosomes promote dendritic cell migration along guidance cues

Authors:
Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong YK, Bennett KL, Kain R, Detmar M, Sixt M, Jackson DG, Kerjaschki D
Citation:
J Cell Biol. 2018 Apr 12. pii: jcb.201612051. doi: 10.1083/jcb.201612051. [Epub ahead of print]
Epub:
Yes
Abstract:
Lymphatic endothelial cells (LECs) release extracellular chemokines to guide the migration of dendritic cells. In this study,...
Link:
http://jcb.rupress.org/content/early/2018/04/11/jcb.201612051
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: Primary human dermal microvascular lymphatic endothelial cells (LEC)
Citation Extract:
Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong YK, Bennett KL, Kain R, Detmar M, Sixt M, Jackson DG, Kerjaschki D. Lymphatic exosomes promote dendritic cell migration along guidance cues. J Cell Biol. 2018 Apr 12. pii: jcb.201612051. doi: 10.1083/jcb.201612051. [Epub ahead of print].

Phosphorodiamidate morpholino targeting the 5' untranslated region of the ZIKV RNA inhibits virus replication

Authors:
Popik W, Khatua A, Hildreth JEK, Lee B, Alcendor DJ
Citation:
Virology. 2018 Jun;519:77-85. doi: 10.1016/j.virol.2018.04.001. Epub 2018 Apr 19. PMID: 29679791; PMCID: PMC6503319
Epub:
Not Epub
Abstract:
BACKGROUND: Zika virus (ZIKV) infection has been associated with microcephaly in infants. Currently there is no treatment or...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6503319/
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human glomerular podocytes
Citation Extract:
Popik W, Khatua A, Hildreth JEK, Lee B, Alcendor DJ. Phosphorodiamidate morpholino targeting the 5' untranslated region of the ZIKV RNA inhibits virus replication. Virology. 2018 Jun;519:77-85. doi: 10.1016/j.virol.2018.04.001. Epub 2018 Apr 19. PMID: 29679791; PMCID: PMC6503319.

Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure

Authors:
Tampe B, Tampe D, Nyamsuren G, Klöpper F, Rapp G, Kauffels A, Lorf T, Zeisberg EM, Müller GA, Kalluri R, Hakroush S, Zeisberg M
Citation:
J Clin Invest. 2018 Apr 17. pii: 89632. doi: 10.1172/JCI89632. [Epub ahead of print]
Epub:
Yes
Abstract:
Progression of chronic kidney disease associated with progressive fibrosis and impaired tubular epithelial regeneration is...
Link:
https://www.jci.org/articles/view/89632
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Tampe B, Tampe D, Nyamsuren G, Klöpper F, Rapp G, Kauffels A, Lorf T, Zeisberg EM, Müller GA, Kalluri R, Hakroush S, Zeisberg M. Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure. J Clin Invest. 2018 Apr 17. pii: 89632. doi: 10.1172/JCI89632. [Epub ahead of print].

Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome

Authors:
Cloney K, Steele SL, Stoyek MR, Croll RP, Smith FM, Prykhozhij SV, Brown MM, Midgen C, Blake K, Berman JN
Citation:
FEBS J. 2018 Apr 16. doi: 10.1111/febs.14473. [Epub ahead of print]
Epub:
Yes
Abstract:
CHARGE syndrome is linked to autosomal dominant mutations in the CHD7 gene and results in a number of physiological and...
Link:
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.14473
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cloney K, Steele SL, Stoyek MR, Croll RP, Smith FM, Prykhozhij SV, Brown MM, Midgen C, Blake K, Berman JN. Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome. FEBS J. 2018 Apr 16. doi: 10.1111/febs.14473. [Epub ahead of print].

Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos

Authors:
Duan J, Liang S, Yu Y, Li Y, Wang L, Wu Z, Chen Y, Miller MR, Sun Z
Citation:
Nanotoxicology. 2018 Apr 14:1-15. doi: 10.1080/17435390.2018.1461267. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Nowadays, nanotechnology environmental health and safety (nanoEHS) is gaining attention. We previously found that silica...
Link:
https://www.tandfonline.com/doi/abs/10.1080/17435390.2018.1461267
Organism or Cell Type:
zebrafish
Citation Extract:
Duan J, Liang S, Yu Y, Li Y, Wang L, Wu Z, Chen Y, Miller MR, Sun Z. Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos. Nanotoxicology. 2018 Apr 14:1-15. doi: 10.1080/17435390.2018.1461267. [Epub ahead of print].

Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation

Authors:
Aizen J, Pang Y, Harris C, Converse A, Zhu Y, Aguirre MA, Thomas P
Citation:
Gen Comp Endocrinol. 2018 Apr 9. pii: S0016-6480(17)30757-8. doi: 10.1016/j.ygcen.2018.04.009. [Epub ahead of print]
Epub:
Yes
Abstract:
Although previous studies suggest membrane progesterone receptor alpha (mPRα/Paqr7) mediates 17, 20β-dihydroxy-4-pregnen-3-one...
Link:
https://www.sciencedirect.com/science/article/pii/S0016648017307578
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Aizen J, Pang Y, Harris C, Converse A, Zhu Y, Aguirre MA, Thomas P. Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation. Gen Comp Endocrinol. 2018 Apr 9. pii: S0016-6480(17)30757-8. doi: 10.1016/j.ygcen.2018.04.009. [Epub ahead of print].

Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy

Authors:
Komaki H, Nagata T, Saito T, Masuda S, Takeshita E, Sasaki M, Tachimori H, Nakamura H, Aoki Y, Takeda S
Citation:
Sci Transl Med. 2018 Apr 18;10(437). pii: eaan0713. doi: 10.1126/scitranslmed.aan0713
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a lethal hereditary muscle disease caused by mutations in the gene encoding the muscle...
Link:
http://stm.sciencemag.org/content/10/437/eaan0713
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Komaki H, Nagata T, Saito T, Masuda S, Takeshita E, Sasaki M, Tachimori H, Nakamura H, Aoki Y, Takeda S. Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy. Sci Transl Med. 2018 Apr 18;10(437). pii: eaan0713. doi: 10.1126/scitranslmed.aan0713.

Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia

Authors:
Guissart C, Latypova X, Rollier P, Khan TN, Stamberger H, McWalter K, Cho MT, Kjaergaard S, Weckhuysen S, Lesca G, Besnard T, Õunap K, Schema J, Chiocchetti AG, McDonald M, de Bellescize J, Vincent M, Van Esch H, Sattler S, Forghani I, Thiffault I, Freitag CM, Barbouth DS, Cadieux-Dion M, Willaert R, Sacoto MJG, Safina NP, Dubourg C, Grote L, Carré W, Saunders C, Pajusalu S, Farrow E, Boland A, Karlowicz DH, Deleuze J-F, Wojcik MH, Pressman R, Isidor B, Vogels A, Van Paesschen W, Al-Gazali J, Al Shamsi AM, Claustres M, Pujol A, Sanders SJ, Rivier F, Leboucq N, Cogné B, Sasorith S, Sanlaville D, Retterer K, Odent S, Katsanis N, Bézieau S, Koenig M, Davis EE, Pasquier L, Küry S
Citation:
Am J Hum Genet. 2018;[Epub ahead of print] doi:10.1016/j.ajhg.2018.02.021
Epub:
Not Epub
Abstract:
RORα, the RAR-related orphan nuclear receptor alpha, is essential for cerebellar development. The spontaneous mutant mouse...
Link:
http://www.cell.com/ajhg/fulltext/S0002-9297(18)30089-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guissart C, Latypova X, Rollier P, Khan TN, Stamberger H, McWalter K, Cho MT, Kjaergaard S, Weckhuysen S, Lesca G, Besnard T, Õunap K, Schema J, Chiocchetti AG, McDonald M, de Bellescize J, Vincent M, Van Esch H, Sattler S, Forghani I, Thiffault I, Freitag CM, Barbouth DS, Cadieux-Dion M, Willaert R, Sacoto MJG, Safina NP, Dubourg C, Grote L, Carré W, Saunders C, Pajusalu S, Farrow E, Boland A, Karlowicz DH, Deleuze J-F, Wojcik MH, Pressman R, Isidor B, Vogels A, Van Paesschen W, Al-Gazali J, Al Shamsi AM, Claustres M, Pujol A, Sanders SJ, Rivier F, Leboucq N, Cogné B, Sasorith S, Sanlaville D, Retterer K, Odent S, Katsanis N, Bézieau S, Koenig M, Davis EE, Pasquier L, Küry S. Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia. Am J Hum Genet. 2018;[Epub ahead of print] doi:10.1016/j.ajhg.2018.02.021.

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