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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice

Authors:
Han G. Lin L, Ning H, Gao X, Yin HF
Citation:
Molec Ther Nucl Acids. 2018;12(7):478-89. doi:10.1016/j.omtn.2018.06.005
Epub:
Not Epub
Abstract:
Approval of antisense oligonucleotide eteplirsen highlights the promise of exon-skipping therapeutics for Duchenne muscular...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(18)30132-X.pdf
Delivery Method:
i.v. injection
Organism or Cell Type:
mice mdx
Citation Extract:
Han G. Lin L, Ning H, Gao X, Yin HF. Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice. Molec Ther Nucl Acids. 2018;12(7):478-89. doi:10.1016/j.omtn.2018.06.005.

Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis

Authors:
Zhou T, Chen C, Xu C, Zhou H, Gao B, Su D, Liao Z, Li Y, Yang S, Su P
Citation:
Cell Physiol Biochem. 2018 Jul 20;48(3):880-890. doi: 10.1159/000491956. [Epub ahead of print]
Epub:
Not Epub
Abstract:
BACKGROUND/AIMS: Three rare MAPK7 variants that predispose individuals to adolescent idiopathic scoliosis have previously been...
Link:
https://www.karger.com/Article/FullText/491956
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou T, Chen C, Xu C, Zhou H, Gao B, Su D, Liao Z, Li Y, Yang S, Su P. Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis. Cell Physiol Biochem. 2018 Jul 20;48(3):880-890. doi: 10.1159/000491956. [Epub ahead of print].

Detection of unique Ebola virus oligonucleotides using fluorescently-labeled phosphorodiamidate morpholino oligonucleotide probe pairs

Authors:
Xiong Y, McQuistan TJ, Stanek JW, Summerton JE, Mata JE, Squier TC
Citation:
Anal Biochem. 2018 Sep 15;557:84-90. doi: 10.1016/j.ab.2018.07.006. Epub 2018 Jul 18. PMID: 30030994
Epub:
Not Epub
Abstract:
Here we identify a low-cost diagnostic platform using fluorescently-labeled phosphorodiamidate morpholino oligonucleotide (PMO...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0003269718306249
Citation Extract:
Xiong Y, McQuistan TJ, Stanek JW, Summerton JE, Mata JE, Squier TC. Detection of unique Ebola virus oligonucleotides using fluorescently-labeled phosphorodiamidate morpholino oligonucleotide probe pairs. Anal Biochem. 2018 Sep 15;557:84-90. doi: 10.1016/j.ab.2018.07.006. Epub 2018 Jul 18. PMID: 30030994.

Generation and Validation of a Complete Knockout Model of abcc6a In Zebrafish

Authors:
Van Gils M, Willaert A, De Vilder EYG, Coucke P, Vanakker OM
Citation:
J Invest Dermatol. 2018 Jul 17. pii: S0022-202X(18)32326-1. doi: 10.1016/j.jid.2018.06.183. [Epub ahead of print]
Epub:
Yes
Abstract:
Pseudoxanthoma elasticum is an ectopic mineralization disease due to biallelic ABCC6 mutations. As no treatment options are...
Link:
https://www.jidonline.org/article/S0022-202X(18)32326-1/pdf
Organism or Cell Type:
zebrafish
Citation Extract:
Van Gils M, Willaert A, De Vilder EYG, Coucke P, Vanakker OM. Generation and Validation of a Complete Knockout Model of abcc6a In Zebrafish. J Invest Dermatol. 2018 Jul 17. pii: S0022-202X(18)32326-1. doi: 10.1016/j.jid.2018.06.183. [Epub ahead of print].

Investigating the Role of G Protein βγ in Kv7-Dependent Relaxations of the Rat Vasculature

Authors:
Stott JB, Barrese V, Suresh M, Masoodi S, Greenwood IA
Citation:
Arterioscler Thromb Vasc Biol. 2018 Jul 12. pii: ATVBAHA.118.311360. doi: 10.1161/ATVBAHA.118.311360. [Epub ahead of print]
Epub:
Yes
Abstract:
OBJECTIVE: In renal arteries, inhibitors of G protein βγ subunits (Gβγ) reduce Kv7 activity and inhibit Kv7-dependent receptor-...
Link:
https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311360
Delivery Method:
Lipofectamine 2000
Organism or Cell Type:
cell culture: rat dissected renal artery, mesenteric artery and cerebral artery
Citation Extract:
Stott JB, Barrese V, Suresh M, Masoodi S, Greenwood IA. Investigating the Role of G Protein βγ in Kv7-Dependent Relaxations of the Rat Vasculature. Arterioscler Thromb Vasc Biol. 2018 Jul 12. pii: ATVBAHA.118.311360. doi: 10.1161/ATVBAHA.118.311360. [Epub ahead of print].

Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4

Authors:
Hehr CL, Halabi R, McFarlane S
Citation:
Cell Adh Migr. 2018 Jul 31:1-14. doi: 10.1080/19336918.2018.1477900. [Epub ahead of print]
Epub:
Not Epub
Abstract:
During development, neuroepithelial progenitors acquire apico-basal polarity and adhere to one another via apically located...
Link:
https://www.tandfonline.com/doi/abs/10.1080/19336918.2018.1477900
Organism or Cell Type:
zebrafish
Citation Extract:
Hehr CL, Halabi R, McFarlane S. Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4. Cell Adh Migr. 2018 Jul 31:1-14. doi: 10.1080/19336918.2018.1477900. [Epub ahead of print].

Alternative splicing of (ppp1r12a/mypt1) in zebrafish produces a novel myosin phosphatase targeting subunit

Authors:
LaFlamme A, Young KE, Lang I, Weiser DC
Citation:
Gene. 2018 Jun 27. pii: S0378-1119(18)30753-4. doi: 10.1016/j.gene.2018.06.092. [Epub ahead of print]
Epub:
Yes
Abstract:
Myosin phosphatase is an evolutionarily conserved regulator of actomyosin contractility, comprised of a regulatory subunit (...
Link:
https://www.sciencedirect.com/science/article/pii/S0378111918307534?via%3Dihub
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
LaFlamme A, Young KE, Lang I, Weiser DC. Alternative splicing of (ppp1r12a/mypt1) in zebrafish produces a novel myosin phosphatase targeting subunit. Gene. 2018 Jun 27. pii: S0378-1119(18)30753-4. doi: 10.1016/j.gene.2018.06.092. [Epub ahead of print].

Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal Function

Authors:
Chitramuthu BP, Bennett HPJ
Citation:
Methods Mol Biol. 2018;1806:207-231. doi: 10.1007/978-1-4939-8559-3_15
Epub:
Not Epub
Abstract:
The zebrafish (Danio rerio), a small tropical fish, has become a powerful model for the study of early vertebrate development,...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8559-3_15
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chitramuthu BP, Bennett HPJ. Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal Function. Methods Mol Biol. 2018;1806:207-231. doi: 10.1007/978-1-4939-8559-3_15.

Effect of Tim23 Knockdown in vivo on Mitochondrial Protein Import and Retrograde Signaling to the UPRmt in Muscle

Authors:
Oliveira AN, Hood DA
Citation:
Am J Physiol Cell Physiol. 2018 Jun 27. doi: 10.1152/ajpcell.00275.2017. [Epub ahead of print]
Epub:
Yes
Abstract:
The mitochondrial unfolded protein response (UPRmt) is a protein quality control mechanism that strives to achieve proteostasis...
Link:
https://www.physiology.org/doi/abs/10.1152/ajpcell.00275.2017
Delivery Method:
Vivo-Morpholino
Citation Extract:
Oliveira AN, Hood DA. Effect of Tim23 Knockdown in vivo on Mitochondrial Protein Import and Retrograde Signaling to the UPRmt in Muscle. Am J Physiol Cell Physiol. 2018 Jun 27. doi: 10.1152/ajpcell.00275.2017. [Epub ahead of print].

Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium

Authors:
Neelathi UM, Dalle Nogare D, Chitnis AB
Citation:
Development. 2018 Jul 30;145(14). pii: dev162453. doi: 10.1242/dev.162453
Epub:
Not Epub
Abstract:
The zebrafish posterior lateral line primordium migrates along a path defined by the chemokine Cxcl12a, periodically depositing...
Link:
http://dev.biologists.org/content/145/14/dev162453.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Neelathi UM, Dalle Nogare D, Chitnis AB. Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium. Development. 2018 Jul 30;145(14). pii: dev162453. doi: 10.1242/dev.162453.

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