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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish

Authors:
Li J, Sun Z
Citation:
PLoS ONE. 2011;6(11): e27365. doi:10.1371/journal.pone.0027365
Epub:
Not Epub
Abstract:
Defects in the cilium, a once thought vestigial organelle, have recently been implicated in many human diseases, including a...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li J, Sun Z. Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish. PLoS ONE. 2011;6(11): e27365. doi:10.1371/journal.pone.0027365.

Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking

Authors:
Lee CW, Han J, Bamburg JR, Han L, Lynn R, Zheng JQ
Citation:
Nat Neurosci. 2009 May 31. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Postsynaptic receptor localization is crucial for synapse development and function, but the underlying cytoskeletal mechanisms...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Lee CW, Han J, Bamburg JR, Han L, Lynn R, Zheng JQ. Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking. Nat Neurosci. 2009 May 31. [Epub ahead of print].

Reiterated Wnt signaling during zebrafish neural crest development.

Authors:
Lewis JL, Bonner J, Modrell M, Ragland JW, Moon RT, Dorsky RI, Raible DW.
Citation:
Development. 2004 Mar;131(6):1299-308.
Epub:
Not Epub
Abstract:
While Wnt/beta-catenin signaling is known to be involved in the development of neural crest cells in zebrafish, it is unclear...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lewis JL, Bonner J, Modrell M, Ragland JW, Moon RT, Dorsky RI, Raible DW.. Reiterated Wnt signaling during zebrafish neural crest development.. Development. 2004 Mar;131(6):1299-308..

RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1

Authors:
Lee JE, Bennett CF, Cooper TA
Citation:
PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1117019109
Epub:
Not Epub
Abstract:
Myotonic dystrophy type 1 (DM1) is an RNA-dominant disease caused by abnormal transcripts containing expanded CUG repeats. The...
Citation Extract:
Lee JE, Bennett CF, Cooper TA. RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1. PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1117019109.

skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization

Authors:
Li H, Randall WR, Du SJ
Citation:
FASEB J. 2009 Jun;23(6):1988-2000. Epub 2009 Feb 11
Epub:
Not Epub
Abstract:
Myofibrillogenesis, the precise assembly of sarcomeric proteins into the highly organized sarcomeres, is essential for muscle...
Organism or Cell Type:
zebrafish
Citation Extract:
Li H, Randall WR, Du SJ. skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization. FASEB J. 2009 Jun;23(6):1988-2000. Epub 2009 Feb 11.

Smad10 is required for formation of the frog nervous system.

Authors:
LeSueur JA, Fortuno ES 3rd, McKay RM, Graff JM.
Citation:
Dev Cell 2002 Jun;2(6):771-83
Epub:
Not Epub
Abstract:
Before the nervous system establishes its complex array of cell types and connections, multipotent cells are instructed to...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
LeSueur JA, Fortuno ES 3rd, McKay RM, Graff JM.. Smad10 is required for formation of the frog nervous system.. Dev Cell 2002 Jun;2(6):771-83.

Smyd1b is required for skeletal and cardiac muscle function in zebrafish

Authors:
Li H, Zhong Y, Wang Z, Gao J, Xu J, Chu W, Zhang J, Fang S, Du SJ
Citation:
Mol Biol Cell. 2013 Sep 25. [Epub ahead of print]
Epub:
Yes
Abstract:
Smyd1b is a member of the Smyd family, which is specifically expressed in skeletal and cardiac muscles. Smyd1b plays a key role...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li H, Zhong Y, Wang Z, Gao J, Xu J, Chu W, Zhang J, Fang S, Du SJ. Smyd1b is required for skeletal and cardiac muscle function in zebrafish. Mol Biol Cell. 2013 Sep 25. [Epub ahead of print].

Smyd1b_tv1, a Key Regulator of Sarcomere Assembly, Is Localized on the M-Line of Skeletal Muscle Fibers

Authors:
Li H, Xu J, Bian Y-H, Rotllant P, Shen T, Chu W, Zhang J, Schneider M, Du SJ
Citation:
PLoS ONE. 2011; 6(12):e28524. doi:10.1371/journal.pone.0028524
Epub:
Not Epub
Abstract:
Background Smyd1b is a member of the Smyd family that plays a key role in sarcomere assembly during myofibrillogenesis. Smyd1b...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li H, Xu J, Bian Y-H, Rotllant P, Shen T, Chu W, Zhang J, Schneider M, Du SJ. Smyd1b_tv1, a Key Regulator of Sarcomere Assembly, Is Localized on the M-Line of Skeletal Muscle Fibers. PLoS ONE. 2011; 6(12):e28524. doi:10.1371/journal.pone.0028524.

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

Authors:
Lefave CV, Squatrito M, Vorlova S, Rocco GL, Brennan CW, Holland EC, Pan YX, Cartegni L
Citation:
EMBO J. 2011 Sep 13;30(19):4084-97. doi: 10.1038/emboj.2011.259
Epub:
Not Epub
Abstract:
In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour establishment, progression and...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: cell lines and primary tumor cultures
Citation Extract:
Lefave CV, Squatrito M, Vorlova S, Rocco GL, Brennan CW, Holland EC, Pan YX, Cartegni L. Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas. EMBO J. 2011 Sep 13;30(19):4084-97. doi: 10.1038/emboj.2011.259.

Systemic Delivery of a Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy

Authors:
Leger AJ, Mosquea LM, Clayton NP, Wu IH, Weeden T, Nelson CA, Phillips L, Roberts E, Piepenhagen PA, Cheng SH, Wentworth BM
Citation:
Nucleic Acid Ther. 2013 Jan 11. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Expansions of CUG trinucleotide sequences in RNA transcripts provide the basis for toxic RNA gain-of-function that leads to...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mouse HSA(LR)
Citation Extract:
Leger AJ, Mosquea LM, Clayton NP, Wu IH, Weeden T, Nelson CA, Phillips L, Roberts E, Piepenhagen PA, Cheng SH, Wentworth BM. Systemic Delivery of a Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy. Nucleic Acid Ther. 2013 Jan 11. [Epub ahead of print].

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