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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

PAK1 regulates spindle microtubule organization during oocyte meiotic maturation

Authors:
Lin SL, Qi ST, Sun SC, Wang YP, Schatten H, Sun QY
Citation:
Front Biosci (Elite Ed). 2010 Jun 1;2:1254-64
Epub:
Not Epub
Abstract:
P21-activated kinase 1 (PAK1), an effector of Rho GTPase Rac 1 and Cdc42, is required for mitotic progression. However, its...
Delivery Method:
Microinjection
Organism or Cell Type:
mouse oocytes
Citation Extract:
Lin SL, Qi ST, Sun SC, Wang YP, Schatten H, Sun QY. PAK1 regulates spindle microtubule organization during oocyte meiotic maturation. Front Biosci (Elite Ed). 2010 Jun 1;2:1254-64.

Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling

Authors:
Liu JAJ, Wu M-H, Yan CH, Chau BKH, So H, Ng A, Chan A, Cheah KSE, Briscoe J, Cheung M
Citation:
PNAS. 2013;[Epub ahead of print] doi:10.1073/pnas.1211747110
Epub:
Not Epub
Abstract:
Coordination of neural crest cell (NCC) induction and delamination is orchestrated by several transcription factors. Among...
Delivery Method:
Injection then electroporation in vivo
Organism or Cell Type:
chick (Gallus gallus)
Citation Extract:
Liu JAJ, Wu M-H, Yan CH, Chau BKH, So H, Ng A, Chan A, Cheah KSE, Briscoe J, Cheung M. Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling. PNAS. 2013;[Epub ahead of print] doi:10.1073/pnas.1211747110 .

Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish

Authors:
Liu C, Ma W, Su W, Zhang J
Citation:
Development. 2012 Dec;139(24):4591-600. doi: 10.1242/dev.083055. Epub 2012 Nov 7.
Epub:
Not Epub
Abstract:
The precise formation of three-dimensional motor circuits is essential for movement control. Within these circuits, motoneurons...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu C, Ma W, Su W, Zhang J. Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish. Development. 2012 Dec;139(24):4591-600. doi: 10.1242/dev.083055. Epub 2012 Nov 7..

Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice

Authors:
Liu G, Dou S, He J, Liu X, Rusckowski M, Hnatowich DJ
Citation:
Eur J Nucl Med Mol Imaging. 2007 Feb;34(2):237-46
Epub:
Not Epub
Abstract:
PURPOSE: Pretargeting with phosphorodiamidate morpholino oligomers (MORFs) involves administration of a MORF-conjugated anti-...
Delivery Method:
Injection
Organism or Cell Type:
mice, LS174T
Citation Extract:
Liu G, Dou S, He J, Liu X, Rusckowski M, Hnatowich DJ. Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice. Eur J Nucl Med Mol Imaging. 2007 Feb;34(2):237-46.

Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation

Authors:
Liu G, Dou S, Rusckowski M, Greiner D, Hnatowich D
Citation:
Appl Radiat Isot. 2010 Sep;68(9):1709-14. doi: 10.1016/j.apradiso.2010.03.002
Epub:
Not Epub
Abstract:
An ability to quantitate the beta cell mass by noninvasive nuclear imaging will be very useful in the prevention, diagnosis,...
Link:
http://www.sciencedirect.com/science/article/pii/S096980431000120X
Citation Extract:
Liu G, Dou S, Rusckowski M, Greiner D, Hnatowich D. Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation. Appl Radiat Isot. 2010 Sep;68(9):1709-14. doi: 10.1016/j.apradiso.2010.03.002.

Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake

Authors:
Liu G, He J, Dou S, Gupta S, Vanderheyden JL, Rusckowski M, Hnatowich DJ
Citation:
Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):417-24. Epub 2003 Dec 23
Epub:
Not Epub
Abstract:
We have recently shown that accumulation in mouse kidneys of technetium-99m labeled phosphorodiamidate morpholinos (MORFs)...
Delivery Method:
in vivo: injection
Organism or Cell Type:
nude mice
Citation Extract:
Liu G, He J, Dou S, Gupta S, Vanderheyden JL, Rusckowski M, Hnatowich DJ. Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake. Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):417-24. Epub 2003 Dec 23.

Pretargeting vs direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody

Authors:
Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL
Citation:
Nucl Med Biol. 2012 Jul;39(5):645-51. doi: 10.1016/j.nucmedbio.2011.12.001. Epub 2012 Feb 10
Epub:
Not Epub
Abstract:
Introduction Our previous investigation showed the proof-of-concept of islet cell and islet imaging by pretargeting, however,...
Delivery Method:
Injection
Organism or Cell Type:
mice
Citation Extract:
Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul;39(5):645-51. doi: 10.1016/j.nucmedbio.2011.12.001. Epub 2012 Feb 10.

Radiolabeling morpholino oligo with 99mTc tricarbonyl

Authors:
Liu C, Tian J, Deng J, Qiao H, Wang J
Citation:
Nuclear Techniques 2005 ;28( 7):534-537 (Chinese)
Epub:
Not Epub
Abstract:
采用三羰基锝药盒制备三羰基锝([99mTc(CO)3(OH2)3]+),并以DTPA作为双功能螯合剂,标记人工合成的Morpholino寡核苷酸. 高效液相色谱(HPLC)证实,此方法三羰基锝产率大于90％,且产率稳定;Morpholino...
Citation Extract:
Liu C, Tian J, Deng J, Qiao H, Wang J. Radiolabeling morpholino oligo with 99mTc tricarbonyl. Nuclear Techniques 2005 ;28( 7):534-537 (Chinese).

Radiolabeling morpholinos with (90)Y, (111)In, (188)Re and (99m)Tc

Authors:
Liu C, Liu G, Liu N, Zhang YM, He J, Rusckowski M, Hnatowich DJ
Citation:
Nucl Med Biol 2003 Feb;30(2):207-14
Epub:
Not Epub
Abstract:
This laboratory is investigating morpholinos (MORF), a DNA analogue, for radiopharmaceutical applications. While we routinely...
Delivery Method:
in vivo: injection
Organism or Cell Type:
male CD-1 mice
Citation Extract:
Liu C, Liu G, Liu N, Zhang YM, He J, Rusckowski M, Hnatowich DJ. Radiolabeling morpholinos with (90)Y, (111)In, (188)Re and (99m)Tc. Nucl Med Biol 2003 Feb;30(2):207-14.

Radiolabeling of MAG(3)-morpholino oligomers with (188)Re at high labeling efficiency and specific radioactivity for tumor pretargeting

Authors:
Liu G, Dou S, He J, Yin D, Gupta S, Zhang S, Wang Y, Rusckowski M, Hnatowich DJ
Citation:
Appl Radiat Isot. 2006 Sep;64(9):971-8. Epub 2006 May 30.
Epub:
Not Epub
Abstract:
We are investigating a novel pretargeting approach involving an initial IV injection of antitumor antibody conjugated with a...
Delivery Method:
in vivo: injection
Organism or Cell Type:
mice, CD-1
Citation Extract:
Liu G, Dou S, He J, Yin D, Gupta S, Zhang S, Wang Y, Rusckowski M, Hnatowich DJ. Radiolabeling of MAG(3)-morpholino oligomers with (188)Re at high labeling efficiency and specific radioactivity for tumor pretargeting. Appl Radiat Isot. 2006 Sep;64(9):971-8. Epub 2006 May 30..

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