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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12143 scientific papers returned from the database with the search filters currently being used below.

Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination

Authors:
Nakayama T, Al-Maawali A, El-Quessny M, Rajab A, Khalil S, Stoler JM, Tan W-H, Nasir R, Schmitz-Abe K, Hill RS, Partlow JN, Al-Saffar M, Servattalab S, LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G, Barkovich AJ, Markianos K, Poduri A, Mochida GH
Citation:
Am J Hum G. 2015;[Epub ahead of print] doi:10.1016/j.ajhg.2015.03.003
Epub:
Yes
Abstract:
Despite recent advances in understanding the genetic bases of microcephaly, a large number of cases of microcephaly remain...
Link:
http://www.cell.com/ajhg/abstract/S0002-9297%2815%2900104-4
Organism or Cell Type:
zebrafish
Citation Extract:
Nakayama T, Al-Maawali A, El-Quessny M, Rajab A, Khalil S, Stoler JM, Tan W-H, Nasir R, Schmitz-Abe K, Hill RS, Partlow JN, Al-Saffar M, Servattalab S, LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G, Barkovich AJ, Markianos K, Poduri A, Mochida GH. Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. Am J Hum G. 2015;[Epub ahead of print] doi:10.1016/j.ajhg.2015.03.003.

Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction

Authors:
Bagci E, Heijlen M, Vergauwen L, Hagenaars A, Houbrechts AM, Esguerra CV, Blust R, Darras VM, Knapen D
Citation:
PLoS One. 2015 Apr 9;10(4):e0123285. doi: 10.1371/journal.pone.0123285. eCollection 2015
Epub:
Not Epub
Abstract:
Thyroid hormone (TH) balance is essential for vertebrate development. Deiodinase type 1 (D1) and type 2 (D2) increase and...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123285
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bagci E, Heijlen M, Vergauwen L, Hagenaars A, Houbrechts AM, Esguerra CV, Blust R, Darras VM, Knapen D. Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction. PLoS One. 2015 Apr 9;10(4):e0123285. doi: 10.1371/journal.pone.0123285. eCollection 2015.

The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum

Authors:
Ojanen MJ, Turpeinen H, Cordova ZM, Hammarén MM, Harjula SK, Parikka M, Rämet M, Pesu M
Citation:
Infect Immun. April 2015 83:4 1431-1442; Accepted manuscript posted online 26 January 2015, doi: 10.1128/IAI.03135-14
Epub:
Not Epub
Link:
http://iai.asm.org/content/83/4/1431.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ojanen MJ, Turpeinen H, Cordova ZM, Hammarén MM, Harjula SK, Parikka M, Rämet M, Pesu M. The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum. Infect Immun. April 2015 83:4 1431-1442; Accepted manuscript posted online 26 January 2015, doi: 10.1128/IAI.03135-14.

Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

Authors:
Chu B-B, Liao Y-C, Qi W, Xie C, Du X, Wang J, Yang H, Miao H-H, Li B-L, Song B-L
Citation:
Cell. 2015;291-306. doi:10.1016/j.cell.2015.02.019
Epub:
Not Epub
Abstract:
Cholesterol is dynamically transported among organelles, which is essential for multiple cellular functions. However, the...
Link:
http://www.sciencedirect.com/science/article/pii/S0092867415001853
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chu B-B, Liao Y-C, Qi W, Xie C, Du X, Wang J, Yang H, Miao H-H, Li B-L, Song B-L. Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts. Cell. 2015;291-306. doi:10.1016/j.cell.2015.02.019.

Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells

Authors:
Boer EF, Howell ED, Schilling TF, Jette CA, Stewart RA
Citation:
PLoS Genet. 2015 Jan 21;11(1):e1004946. doi: 10.1371/journal.pgen.1004946. eCollection 2015 Jan
Epub:
Not Epub
Abstract:
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate embryo, including the craniofacial...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004946
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boer EF, Howell ED, Schilling TF, Jette CA, Stewart RA. Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells. PLoS Genet. 2015 Jan 21;11(1):e1004946. doi: 10.1371/journal.pgen.1004946. eCollection 2015 Jan.

HOMER2, a Stereociliary Scaffolding Protein, Is Essential for Normal Hearing in Humans and Mice

Authors:
Azaiez H, Decker AR, Booth KT, Simpson AC, Shearer AE, Huygen PL, Bu F, Hildebrand MS, Ranum PT, Shibata SB, Turner A, Zhang Y, Kimberling WJ, Cornell RA, Smith RJ
Citation:
PLoS Genet. 2015 Mar 27;11(3):e1005137. doi: 10.1371/journal.pgen.1005137. eCollection 2015 Feb
Epub:
Not Epub
Abstract:
Hereditary hearing loss is a clinically and genetically heterogeneous disorder. More than 80 genes have been implicated to date...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005137
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Azaiez H, Decker AR, Booth KT, Simpson AC, Shearer AE, Huygen PL, Bu F, Hildebrand MS, Ranum PT, Shibata SB, Turner A, Zhang Y, Kimberling WJ, Cornell RA, Smith RJ. HOMER2, a Stereociliary Scaffolding Protein, Is Essential for Normal Hearing in Humans and Mice. PLoS Genet. 2015 Mar 27;11(3):e1005137. doi: 10.1371/journal.pgen.1005137. eCollection 2015 Feb.

The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric Tubule

Authors:
Oltrabella F, Pietka G, Ramirez IB-R, Mironov A, Starborg T, Drummond IA, Hinchliffe KA, Lowe M
Citation:
PLoS Genet. 2015;11(4):e1005058. doi:10.1371/journal.pgen.1005058
Epub:
Not Epub
Abstract:
Lowe syndrome and Dent-2 disease are caused by mutation of the inositol 5-phosphatase OCRL1. Despite our increased...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005058
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oltrabella F, Pietka G, Ramirez IB-R, Mironov A, Starborg T, Drummond IA, Hinchliffe KA, Lowe M. The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric Tubule. PLoS Genet. 2015;11(4):e1005058. doi:10.1371/journal.pgen.1005058.

Functional Characterization of the spf/ash Splicing Variation in OTC Deficiency of Mice and Man

Authors:
Rivera-Barahona A, Sánchez-Alcudia R, Viecelli HM, Rüfenacht V, Pérez B, Ugarte M, Häberle J, Thöny B, Desviat LR
Citation:
PLoS ONE. 2015;10(4):e0122966. doi:10.1371/journal.pone.0122966
Epub:
Not Epub
Abstract:
The spf/ash mouse model of ornithine transcarbamylase (OTC) deficiency, a severe urea cycle disorder, is caused by a mutation (...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122966
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: Hep3B cells
Citation Extract:
Rivera-Barahona A, Sánchez-Alcudia R, Viecelli HM, Rüfenacht V, Pérez B, Ugarte M, Häberle J, Thöny B, Desviat LR. Functional Characterization of the spf/ash Splicing Variation in OTC Deficiency of Mice and Man. PLoS ONE. 2015;10(4):e0122966. doi:10.1371/journal.pone.0122966.

Dendrimer Conjugates for Light-activated Delivery of Antisense Oligonucleotides

Authors:
Yuan A, Hu Y, Ming X
Citation:
RSC Adv. 2015;{Epub ahead of print] doi:10.1039/C5RA04091D
Epub:
Yes
Abstract:
Therapeutic oligonucleotides, such as splice switching ONs (SSOs), provide opportunity for treating serious, life-threatening...
Link:
http://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra04091d#!divAbstract
Delivery Method:
nanoparticle with photointernalization
Organism or Cell Type:
cell culture: A375 melanoma cells
Citation Extract:
Yuan A, Hu Y, Ming X. Dendrimer Conjugates for Light-activated Delivery of Antisense Oligonucleotides. RSC Adv. 2015;{Epub ahead of print] doi:10.1039/C5RA04091D.

Incomplete splicing of neutrophil-specific genes affects neutrophil development in a zebrafish model of poikiloderma with neutropenia

Authors:
Patil P, Uechi T, Kenmochi N
Citation:
RNA Biol. 2015 Apr 3;12(4):426-434
Epub:
Not Epub
Abstract:
Poikiloderma with neutropenia (PN) is a rare inherited disorder characterized by poikiloderma, facial dysmorphism, pachyonychia...
Link:
http://www.tandfonline.com/doi/abs/10.1080/15476286.2015.1017240#.VSVHo-FtETY
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Patil P, Uechi T, Kenmochi N. Incomplete splicing of neutrophil-specific genes affects neutrophil development in a zebrafish model of poikiloderma with neutropenia. RNA Biol. 2015 Apr 3;12(4):426-434.

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