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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
Regulation of Tak1 alternative splicing by splice-switching oligonucleotides
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Citation:
Biochem Biophys Res Commun. 2018 Feb 20. pii: S0006-291X(18)30397-8. doi: 10.1016/j.bbrc.2018.02.160. [Epub ahead of print] Epub:
Yes Abstract:
Alternative splicing (AS) generates multiple isoforms from a single precursor mRNA, and these isoforms usually exhibit... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
mice Citation Extract: Zhou D, Shao Q, Fan X, Wu P, Lin W, Wei H, He F, Jiang Y. Regulation of Tak1 alternative splicing by splice-switching oligonucleotides. Biochem Biophys Res Commun. 2018 Feb 20. pii: S0006-291X(18)30397-8. doi: 10.1016/j.bbrc.2018.02.160. [Epub ahead of print]. |
Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells
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Citation:
FEBS J. 2018 Feb 23. doi: 10.1111/febs.14414. [Epub ahead of print] Epub:
Yes Abstract:
The bone morphogenetic protein (BMP) signaling pathway plays a central role during vasculature development. Mutations or... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Esser JS, Steiner RE, Deckler M, Schmitt H, Engert B, Link S, Charlet A, Patterson C, Bode C, Zhou Q, Moser M. Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells. FEBS J. 2018 Feb 23. doi: 10.1111/febs.14414. [Epub ahead of print]. |
A Conserved Role of the Unconventional Myosin 1d in Laterality Determination
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Citation:
Curr Biol. 2018;[Epub ahead of print] doi:10.1016/j.cub.2018.01.075 Epub:
Yes Abstract:
Anatomical and functional asymmetries are widespread in the animal kingdom [1, 2]. In vertebrates, many visceral organs are... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, LeBlanc-Straceski JM, Noselli S, Blum M. A Conserved Role of the Unconventional Myosin 1d in Laterality Determination. Curr Biol. 2018;[Epub ahead of print] doi:10.1016/j.cub.2018.01.075. |
Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus
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Citation:
Dev Cell. 2018;[Epub ahead of print] doi:10.1016/j.devcel.2018.01.022 Epub:
Yes Abstract:
Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD)... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Gentsch GE, Spruce T, Monteiro RS, Owens NDL, Martin SR, Smith JC. Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus. Dev Cell. 2018;[Epub ahead of print] doi:10.1016/j.devcel.2018.01.022. |
Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish
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Citation:
PNAS. 2018;[Epub ahead of print] doi:10.1073/pnas.1714056115 Epub:
Yes Abstract:
Nrf2 plays critical roles in animals’ defense against electrophiles and oxidative stress by orchestrating the induction of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Mukaigasa K, Tsujita T, Nguyen VT, Li L, Yagi H, Fuse Y, Nakajima-Takagi Y, Kato K, Yamamoto M, Kobayashi M. Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish. PNAS. 2018;[Epub ahead of print] doi:10.1073/pnas.1714056115. |
The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation
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Citation:
Sci Adv. 2018;4:eaao1261 doi:10.1126/sciadv.aao1261 Epub:
Not Epub Abstract:
Retinoic acid (RA) is an important intercellular signaling molecule in vertebrate development, with a well-established role in... Delivery Method:
microinjection Organism or Cell Type:
Platynereis dumerilii (annelid) Citation Extract: Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Nadendla EK, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M. The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation. Sci Adv. 2018;4:eaao1261 doi:10.1126/sciadv.aao1261. |
Repurposing Dantrolene for Long-term Combination Therapy to Potentiate Antisense-Mediated DMD Exon-Skipping in the mdx mouse
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Citation:
Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.002 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, essential to muscle health.... Delivery Method:
retroorbital injection Organism or Cell Type:
mice mdx Citation Extract: Wang DW, Mokhonova EI, Genevieve C. Kendall GC, Becerra D, Naeini YB, Cantor RM, Spencer MJ, Nelson SF, Miceli MC. Repurposing Dantrolene for Long-term Combination Therapy to Potentiate Antisense-Mediated DMD Exon-Skipping in the mdx mouse. Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.002. |
A dystrophic Duchenne mouse model for testing human antisense oligonucleotides
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Citation:
PLoS ONE. 2018;13(2):e0193289. doi:10.1371/journal.pone.0193289 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease generally caused by reading frame disrupting mutations in... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
del52hDMD/mdx mouse Citation Extract: Veltrop M, van Vliet L, Hulsker M, Claassens J, Brouwers C, Breukel C, van der Kaa J, Linssen MM, den Dunnen JT, Verbeek S, Aartsma-Rus A, van Putten M. A dystrophic Duchenne mouse model for testing human antisense oligonucleotides. PLoS ONE. 2018;13(2):e0193289. doi:10.1371/journal.pone.0193289. |
Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery in vitro and in mdx Mice
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Citation:
Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.004 Epub:
Yes Abstract:
Antisense oligonucleotide (AON) therapy for Duchenne muscular dystrophy has drawn great attention in preclinical and clinical... Delivery Method:
Endo-Porter or Saponin in culture, injection in mice Organism or Cell Type:
cell culture: C2C12E50, C2C12E23; mice, mdx Citation Extract: Wang M, Wu B, Shah SN, Lu P, Lu Q. Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery in vitro and in mdx Mice. Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.004. |
Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates
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Citation:
Proc Natl Acad Sci U S A. 2018 Feb 9. pii: 201711516. doi: 10.1073/pnas.1711516115. [Epub ahead of print] Epub:
Yes Abstract:
Robust morphogenetic events are pivotal for animal embryogenesis. However, comparison of the modes of development of different... Delivery Method:
microinjection Organism or Cell Type:
Nematostella vectensis (sea anemone) Citation Extract: Kirillova A, Genikhovich G, Pukhlyakova E, Demilly A, Kraus Y, Technau U. Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates. Proc Natl Acad Sci U S A. 2018 Feb 9. pii: 201711516. doi: 10.1073/pnas.1711516115. [Epub ahead of print]. |