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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation

Authors:
Wang K, Shen Y, Yang Y, Gan X, Liu G, Hu K, Li Y, Gao Z, Zhu L, Yan G, He L, Shan X, Yang L, Lu S, Zeng H, Pan X, Liu C, Yuan Y, Feng C, Xu W, Zhu C, Xiao W, Dong Y, Wang W, Qiu Q, He S
Citation:
Nature Ecol Evol. 2019;[Epub ahead of print] doi:10.1038/s41559-019-0864-8
Epub:
Yes
Abstract:
It is largely unknown how living organisms - especially vertebrates - survive and thrive in the coldness, darkness and high...
Link:
https://www.nature.com/articles/s41559-019-0864-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang K, Shen Y, Yang Y, Gan X, Liu G, Hu K, Li Y, Gao Z, Zhu L, Yan G, He L, Shan X, Yang L, Lu S, Zeng H, Pan X, Liu C, Yuan Y, Feng C, Xu W, Zhu C, Xiao W, Dong Y, Wang W, Qiu Q, He S. Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation. Nature Ecol Evol. 2019;[Epub ahead of print] doi:10.1038/s41559-019-0864-8.

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia

Authors:
Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, de Angelis MH, Graw J
Citation:
Exp Eye Res. 2019;[Epub ahead of print] doi:10.1016/j.exer.2019.03.024
Epub:
Yes
Abstract:
During an ENU (N-ethyl-N-nitrosourea) mutagenesis screen, we observed a dominant small-eye mutant mouse with viable homozygotes...
Link:
https://www.sciencedirect.com/science/article/pii/S0014483518307024
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, de Angelis MH, Graw J. Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Exp Eye Res. 2019;[Epub ahead of print] doi:10.1016/j.exer.2019.03.024.

Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos

Authors:
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J
Citation:
Development. 2017 Feb 1;144(3):519-528. doi: 10.1242/dev.141390. Epub 2016 Dec 19
Epub:
Not Epub
Abstract:
During development from oocyte to embryo, genetic programs in mouse germ cells are reshaped by chromatin remodeling to...
Link:
http://dev.biologists.org/content/144/3/519
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J. Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos. Development. 2017 Feb 1;144(3):519-528. doi: 10.1242/dev.141390. Epub 2016 Dec 19.

Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis

Authors:
Schwenty-Lara J, Nürnberger A, Borchers A
Citation:
Dev Dyn. 2019 Apr 13. doi: 10.1002/dvdy.39. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Kabuki syndrome is a haploinsufficient congenital multi-organ malformation syndrome, which frequently includes...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/dvdy.39
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schwenty-Lara J, Nürnberger A, Borchers A. Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis. Dev Dyn. 2019 Apr 13. doi: 10.1002/dvdy.39. [Epub ahead of print].

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models

Authors:
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez‐Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao‐Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B
Citation:
EMBO Molec Med. 2019;e8734 [Epub ahead of print] doi:10.15252/emmm.201708734
Epub:
Yes
Abstract:
Mitochondrial diseases (MDs) are a heterogeneous group of devastating and often fatal disorders due to defective oxidative...
Link:
http://embomolmed.embopress.org/content/early/2019/04/12/emmm.201708734
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez‐Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao‐Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B. miR‐181a/b downregulation exerts a protective action on mitochondrial disease models. EMBO Molec Med. 2019;e8734 [Epub ahead of print] doi:10.15252/emmm.201708734.

In Ovo Electroporation of Plasmid DNA and Morpholinos into Specific Tissues During Early Embryogenesis

Authors:
McLennan R, Kulesa PM
Citation:
Neural Crest Cells. 2019. Methods in Molecular Biology (1976):71-82 Springer New York, New York, NY. doi:10.1007/978-1-4939-9412-0_6
Epub:
Not Epub
Abstract:
In ovo electroporation enables transfection of non-viral plasmid DNA and/or morpholinos to fluorescently label and/or perturb...
Link:
https://link.springer.com/protocol/10.1007/978-1-4939-9412-0_6
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
McLennan R, Kulesa PM. In Ovo Electroporation of Plasmid DNA and Morpholinos into Specific Tissues During Early Embryogenesis. Neural Crest Cells. 2019. Methods in Molecular Biology (1976):71-82 Springer New York, New York, NY. doi:10.1007/978-1-4939-9412-0_6.

Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish

Authors:
Gibson JF, Prajsnar TK, Hill CJ, Tooke AK, Serba JJ, Tonge RD, Foster SJ, Grierson AJ, Ingham PW, Renshaw SA, Johnston SA
Citation:
Autophagy. 2021 Jun;17(6):1448-1457. doi: 10.1080/15548627.2020.1765521. Epub 2020 Jun 19. PMID: 32559122; PMCID: PMC8204994
Epub:
Not Epub
Abstract:
Macroautophagy/autophagy functions to degrade cellular components and intracellular pathogens. Autophagy receptors, including...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8204994/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gibson JF, Prajsnar TK, Hill CJ, Tooke AK, Serba JJ, Tonge RD, Foster SJ, Grierson AJ, Ingham PW, Renshaw SA, Johnston SA . Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish. Autophagy. 2021 Jun;17(6):1448-1457. doi: 10.1080/15548627.2020.1765521. Epub 2020 Jun 19. PMID: 32559122; PMCID: PMC8204994.

Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation

Authors:
Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H
Citation:
iScience. 2019;[Epub ahead of print] doi:10.1016/j.isci.2019.04.007
Epub:
Yes
Abstract:
Thalidomide is a teratogen that causes multiple malformations in the developing baby through its interaction with Cereblon (...
Link:
https://www.sciencedirect.com/science/article/pii/S258900421930104X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H . Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience. 2019;[Epub ahead of print] doi:10.1016/j.isci.2019.04.007.

A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish

Authors:
Brastrom LK, Scott CA, Dawson DV, Slusarski DC
Citation:
Biomedicines. 2019;7(2):28 doi:10.3390/biomedicines7020028
Epub:
Not Epub
Abstract:
Debilitating visual impairment caused by cataracts or microphthalmia is estimated to affect roughly 20 million people in the...
Link:
https://www.mdpi.com/2227-9059/7/2/28/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brastrom LK, Scott CA, Dawson DV, Slusarski DC. A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish. Biomedicines. 2019;7(2):28 doi:10.3390/biomedicines7020028.

ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer

Authors:
Daulat AM, Finetti P, Revinski D, Wagner MS, Camoin L, Audebert S, Birnbaum D, Kodjabachian L, Borg J-P, Bertucci F
Citation:
Brit J Cancer. 2019;[Epub ahead of print] doi:doi.org/10.1038/s41416-019-0448-z
Epub:
Yes
Abstract:
Background: Triple-negative breast cancers (TNBC) are poor-prognosis tumours candidate to chemotherapy as only systemic...
Link:
https://www.nature.com/articles/s41416-019-0448-z
Organism or Cell Type:
Xenopus
Citation Extract:
Daulat AM, Finetti P, Revinski D, Wagner MS, Camoin L, Audebert S, Birnbaum D, Kodjabachian L, Borg J-P, Bertucci F. ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer. Brit J Cancer. 2019;[Epub ahead of print] doi:doi.org/10.1038/s41416-019-0448-z.

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