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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo
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Citation:
Development 2001 128(6):849-858 Epub:
Not Epub Abstract:
Ventral specification of mesoderm and ectoderm depends on signaling by members of the bone morphogenetic protein (Bmp) family.... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Bauer H, Lele Z, Rauch GJ, Geisler R, Hammerschmidt M. The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development 2001 128(6):849-858. |
The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain
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Citation:
Development. 2001 Aug;128(16):3081-94 Epub:
Not Epub Abstract:
We describe a new zebrafish mutation, neckless, and present evidence that it inactivates retinaldehyde dehydrogenase type 2, an... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Begemann G, Schilling TF, Rauch GJ, Geisler R, Ingham PW. The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain. Development. 2001 Aug;128(16):3081-94. |
Therapeutic Potential of Splice-Switching Oligonucleotides
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Citation:
Oligonucleotides. 2009 Jan 6. [Epub ahead of print] Epub:
Not Epub Abstract:
Alternative splicing enables a single pre-messenger RNA transcript to yield multiple protein isoforms, making it a major... Citation Extract: Bauman J, Jearawiriyapaisarn N, Kole R. Therapeutic Potential of Splice-Switching Oligonucleotides. Oligonucleotides. 2009 Jan 6. [Epub ahead of print]. |
TIF1gamma controls erythroid cell fate by regulating transcription elongation
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Citation:
Cell. 2010 Jul 9;142(1):133-43 Epub:
Not Epub Abstract:
Recent genome-wide studies have demonstrated that pausing of RNA polymerase II (Pol II) occurred on many vertebrate genes. By... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 9;142(1):133-43. |
Transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibits cytochrome P450 3A2 activity in male rats
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Citation:
Pharm Res. 2002 Oct;19(10):1465-70 Epub:
Not Epub Abstract:
PURPOSE: To determine if dermal absorption of an antisense phosphorodiamidate Morpholino oligomers (PMO) can inhibit target... Delivery Method:
transdermal Organism or Cell Type:
Sprague Dawley rats & hairless CRL:SK1 mice Citation Extract: Arora V, Hannah TL, Iversen PL, Brand RM. Transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibits cytochrome P450 3A2 activity in male rats. Pharm Res. 2002 Oct;19(10):1465-70. |
Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif
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Citation:
Nucleic Acids Res 2001 Dec 1;29(23):4873-80 Epub:
Not Epub Abstract:
Triplex-forming oligonucleotides (TFOs) are good candidates to be used as site-specific DNA-binding agents. Two obstacles... Delivery Method:
not applicable Organism or Cell Type:
not applicable Citation Extract: Basye J, Trent JO, Gao D, Ebbinghaus SW. Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif. Nucleic Acids Res 2001 Dec 1;29(23):4873-80. |
Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling
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Citation:
Development. 2008 Sep;135(17):2927-37 Epub:
Not Epub Abstract:
We identify Balpha (PPP2R2A) and Bdelta (PPP2R2D), two highly related members of the B family of regulatory subunits of the... Organism or Cell Type:
Xenopus Citation Extract: Batut J, Schmierer B, Cao J, Raftery LA, Hill CS, Howell M. Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling. Development. 2008 Sep;135(17):2927-37. |
U1 snRNP determines mRNA length and regulates isoform expression
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Citation:
Cell. 2012 Jul 6;150(1):53-64. doi: 10.1016/j.cell.2012.05.029 Epub:
Not Epub Abstract:
U1 snRNP (U1), in addition to its splicing role, protects pre-mRNAs from drastic premature termination by cleavage and... Delivery Method:
Electroporation Organism or Cell Type:
cell culture: HeLa, NIH/3T3, and S2 cells Citation Extract: Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G. U1 snRNP determines mRNA length and regulates isoform expression. Cell. 2012 Jul 6;150(1):53-64. doi: 10.1016/j.cell.2012.05.029. |
Williams Syndrome Transcription Factor is critical for neural crest cell function in Xenopus laevis
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Citation:
Mech Dev. 2012 Jun 9. [Epub ahead of print] Epub:
Not Epub Abstract:
Williams Syndrome Transcription Factor (WSTF) is one of ∼25 haplodeficient genes in patients with the complex developmental... Delivery Method:
Microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Barnett C, Yazgan O, Kuo HC, Malakar S, Thomas T, Fitzgerald A, Harbour B, Henry JJ, Krebs JE. Williams Syndrome Transcription Factor is critical for neural crest cell function in Xenopus laevis. Mech Dev. 2012 Jun 9. [Epub ahead of print]. |
WNK1/HSN2 Mutation in Human Peripheral Neuropathy Deregulates KCC2 Expression and Posterior Lateral Line Development in Zebrafish (Danio rerio)
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Citation:
PLoS Genet. 2013;9(1):e1003124. doi:10.1371/journal.pgen.1003124 Epub:
Not Epub Abstract:
Hereditary sensory and autonomic neuropathy type 2 (HSNAII) is a rare pathology characterized by an early onset of severe... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Bercier V, Brustein E, Liao M, Dion PA, Lafrenière RG, Rouleau GA, Drapeau P. WNK1/HSN2 Mutation in Human Peripheral Neuropathy Deregulates KCC2 Expression and Posterior Lateral Line Development in Zebrafish (Danio rerio). PLoS Genet. 2013;9(1):e1003124. doi:10.1371/journal.pgen.1003124. |