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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cells

Authors:
Aartsma-Rus A, Kaman WE, Bremmer-Bout M, Janson AA, Den Dunnen JT, Van Ommen GJ, Van Deutekom JC
Citation:
Gene Ther. 2004 Sep;11(18):1391-8.
Epub:
Not Epub
Abstract:
As small molecule drugs for Duchenne muscular dystrophy (DMD), antisense oligonucleotides (AONs) have been shown to restore the...
Delivery Method:
Special Delivery
Organism or Cell Type:
Cell culture: primary human myoblast
Citation Extract:
Aartsma-Rus A, Kaman WE, Bremmer-Bout M, Janson AA, Den Dunnen JT, Van Ommen GJ, Van Deutekom JC. Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cells. Gene Ther. 2004 Sep;11(18):1391-8..

Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome

Authors:
Albers CA, Paul DS, Schulze H, Freson K, Stephens JC, Smethurst PA, Jolley JD, Cvejic A, Kostadima M, Bertone P, Breuning MH, Debili N, Deloukas P, Favier R, Fiedler J, Hobbs CM, Huang N, Hurles ME, Kiddle G, Krapels I, Nurden P, Ruivenkamp CA, Sambrook JG, Smith K, Stemple DL, Strauss G, Thys C, van Geet C, Newbury-Ecob R, Ouwehand WH, Ghevaert C
Citation:
Nat Genet. 2012 Feb 26;44(4):435-9, S1-2. doi: 10.1038/ng.1083
Epub:
Not Epub
Abstract:
The exon-junction complex (EJC) performs essential RNA processing tasks1-5. Here, we describe the first human disorder,...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Albers CA, Paul DS, Schulze H, Freson K, Stephens JC, Smethurst PA, Jolley JD, Cvejic A, Kostadima M, Bertone P, Breuning MH, Debili N, Deloukas P, Favier R, Fiedler J, Hobbs CM, Huang N, Hurles ME, Kiddle G, Krapels I, Nurden P, Ruivenkamp CA, Sambrook JG, Smith K, Stemple DL, Strauss G, Thys C, van Geet C, Newbury-Ecob R, Ouwehand WH, Ghevaert C. Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. Nat Genet. 2012 Feb 26;44(4):435-9, S1-2. doi: 10.1038/ng.1083.

Conserved Functions for Mos in Eumetazoan Oocyte Maturation Revealed by Studies in a Cnidarian

Authors:
Amiel A, Leclère L, Robert L, Chevalier S, Houliston E
Citation:
Curr Biol. 2009 Feb 18. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The kinase Mos, which activates intracellularly the MAP kinase pathway, is a key regulator of animal oocyte meiotic maturation...
Organism or Cell Type:
Clytia hemisphaerica
Citation Extract:
Amiel A, Leclère L, Robert L, Chevalier S, Houliston E. Conserved Functions for Mos in Eumetazoan Oocyte Maturation Revealed by Studies in a Cnidarian. Curr Biol. 2009 Feb 18. [Epub ahead of print].

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) BY NkX2.2 and neurogenin 3

Authors:
Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L
Citation:
J Biol Chem. 2009 Sep 15. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Nkx2.2 and NeuroD1 are two critical regulators of pancreatic beta cell development. Nkx2.2 is a homeodomain transcription...
Organism or Cell Type:
zebrafish
Citation Extract:
Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) BY NkX2.2 and neurogenin 3. J Biol Chem. 2009 Sep 15. [Epub ahead of print].

Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies

Authors:
Abes R, Moulton HM, Clair P, Yang ST, Abes S, Melikov K, Prevot P, Youngblood DS, Iversen PL, Chernomordik LV, Lebleu B
Citation:
Nucleic Acids Res. 2008 Nov;36(20):6343-54. Epub 2008 Sep 16
Epub:
Not Epub
Abstract:
Redirecting the splicing machinery through the hybridization of high affinity, RNase H- incompetent oligonucleotide analogs...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa AntisenseTest System
Citation Extract:
Abes R, Moulton HM, Clair P, Yang ST, Abes S, Melikov K, Prevot P, Youngblood DS, Iversen PL, Chernomordik LV, Lebleu B. Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies. Nucleic Acids Res. 2008 Nov;36(20):6343-54. Epub 2008 Sep 16.

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish

Authors:
Anastasaki C, Longman D, Capper A, Patton EE, Cáceres JF
Citation:
Nucleic Acids Res. 2011 Jan 11. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The nonsense-mediated mRNA decay (NMD) pathway is a highly conserved surveillance mechanism that is present in all eukaryotes....
Organism or Cell Type:
zebrafish
Citation Extract:
Anastasaki C, Longman D, Capper A, Patton EE, Cáceres JF. Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic Acids Res. 2011 Jan 11. [Epub ahead of print].

Disruption of gene function using antisense morpholinos.

Authors:
Angerer LM, Angerer RC
Citation:
Methods Cell Biol. 2004;74:699-711
Epub:
Not Epub
Abstract:
No abstract available.
Citation Extract:
Angerer LM, Angerer RC. Disruption of gene function using antisense morpholinos.. Methods Cell Biol. 2004;74:699-711.

DNA duplex-quadruplex exchange as the basis for a nanomolecular machine

Authors:
Alberti P, Mergny JL.
Citation:
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1569-73. Epub 2003 Feb 06
Epub:
Not Epub
Abstract:
There is currently great interest in the design of nanodevices that are capable of performing linear or rotary movements....
Delivery Method:
not applicable
Organism or Cell Type:
not applicable
Citation Extract:
Alberti P, Mergny JL.. DNA duplex-quadruplex exchange as the basis for a nanomolecular machine. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1569-73. Epub 2003 Feb 06.

Docking protein SNT1 is a critical mediator of fibroblast growth factor signaling during Xenopus embryonic development.

Authors:
Akagi K, Park EK, Mood K, Daar IO
Citation:
Dev Dyn. 2002 Mar;223(2):216-28.
Epub:
Not Epub
Abstract:
The docking protein SNT1/FRS2 (fibroblast growth factor receptor substrate 2) is implicated in the transmission of...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Akagi K, Park EK, Mood K, Daar IO. Docking protein SNT1 is a critical mediator of fibroblast growth factor signaling during Xenopus embryonic development.. Dev Dyn. 2002 Mar;223(2):216-28..

Early development of forebrain gonadotrophin-releasing hormone (GnRH) neurones and the role of GnRH as an autocrine migration factor.

Authors:
Abraham E, Palevitch O, Ijiri S, Du SJ, Gothilf Y, Zohar Y
Citation:
J Neuroendocrinol. 2008 Mar;20(3):394-405. doi: 10.1111/j.1365-2826.2008.01654.x. Epub 2008 Jan 17.
Epub:
Not Epub
Abstract:
Normal migration of the GnRH-I neurones during early development, from the olfactory region to the hypothalamus, is crucial for...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2008.01654.x/abstract
Organism or Cell Type:
zebrafish
Citation Extract:
Abraham E, Palevitch O, Ijiri S, Du SJ, Gothilf Y, Zohar Y. Early development of forebrain gonadotrophin-releasing hormone (GnRH) neurones and the role of GnRH as an autocrine migration factor.. J Neuroendocrinol. 2008 Mar;20(3):394-405. doi: 10.1111/j.1365-2826.2008.01654.x. Epub 2008 Jan 17..

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