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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

MAPK and GSK3/ß-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo

Authors:
Molina MD, Quirin M, Haillot E, De Crozé N, Range R, Rouel M, Jimenez F, Amrouche R, Chessel A, Lepage T
Citation:
PLoS Genet. 2018;14(9):e1007621. doi:10.1371/journal.pgen.1007621
Epub:
Not Epub
Abstract:
In the sea urchin embryo, specification of the dorsal-ventral axis critically relies on the spatially restricted expression of...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007621
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Molina MD, Quirin M, Haillot E, De Crozé N, Range R, Rouel M, Jimenez F, Amrouche R, Chessel A, Lepage T. MAPK and GSK3/ß-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo. PLoS Genet. 2018;14(9):e1007621. doi:10.1371/journal.pgen.1007621.

Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury

Authors:
Yao M, Rogers NM, Csányi G, Rodriguez AI, Ross MA, St Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ, Isenberg JS
Citation:
J Am Soc Nephrol. 2014 Jun;25(6):1171-86. doi: 10.1681/ASN.2013040433. Epub 2014 Feb 7. Erratum in: J Am Soc Nephrol. 2014 Aug;25(8):1884
Epub:
Not Epub
Abstract:
Ischemia reperfusion injury (IRI) causes tissue and organ injury, in part, through alterations in tissue blood flow and the...
Link:
https://jasn.asnjournals.org/content/early/2014/02/05/ASN.2013040433
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: rat aortic VSMC
Citation Extract:
Yao M, Rogers NM, Csányi G, Rodriguez AI, Ross MA, St Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ, Isenberg JS. Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury. J Am Soc Nephrol. 2014 Jun;25(6):1171-86. doi: 10.1681/ASN.2013040433. Epub 2014 Feb 7. Erratum in: J Am Soc Nephrol. 2014 Aug;25(8):1884.

Polycystin-1 regulates bone development through an interaction with the transcriptional co-activator taz

Authors:
Merrick D, Mistry K, Wu J, Gresko N, Baggs JE, Hogenesch JB, Sun Z, Caplan MJ
Citation:
Hum Mol Genet. 2018 Sep 12. doi: 10.1093/hmg/ddy322. [Epub ahead of print]
Epub:
Yes
Abstract:
Polycystin-1 (PC1), encoded by the PKD1 gene that is mutated in Autosomal Dominant Polycystic Kidney disease, regulates a...
Link:
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddy322/5095320
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Merrick D, Mistry K, Wu J, Gresko N, Baggs JE, Hogenesch JB, Sun Z, Caplan MJ. Polycystin-1 regulates bone development through an interaction with the transcriptional co-activator taz. Hum Mol Genet. 2018 Sep 12. doi: 10.1093/hmg/ddy322. [Epub ahead of print].

A Japanese phase I/II study of NS-065/NCNP-01, exon 53 skipping drug, in patients with Duchenne muscular dystrophy - a dose-finding study

Authors:
Komaki H, Takeshima Y, Matsumura T, Ozasa S, Funato M, Egawa Y, Takeda S
Citation:
Neuromusc Disord. 2018;28:P129. doi:10.1016/j.nmd.2018.06.157
Epub:
Not Epub
Abstract:
no abstract available
Link:
https://www.nmd-journal.com/article/S0960-8966(18)30720-X/fulltext
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Komaki H, Takeshima Y, Matsumura T, Ozasa S, Funato M, Egawa Y, Takeda S. A Japanese phase I/II study of NS-065/NCNP-01, exon 53 skipping drug, in patients with Duchenne muscular dystrophy - a dose-finding study. Neuromusc Disord. 2018;28:P129. doi:10.1016/j.nmd.2018.06.157.

Respiratory function decline in eteplirsen-treated patients diverges from natural history comparators over time

Authors:
Khan N, Han L, Kinane B, Gordish-Dressman H, Lowes L, McDonald C
Citation:
Neuromusc Disord. 2018;28:P126. doi:10.1016/j.nmd.2018.06.154
Epub:
Not Epub
Abstract:
no abstract available
Link:
https://www.nmd-journal.com/article/S0960-8966(18)30717-X/fulltext
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Khan N, Han L, Kinane B, Gordish-Dressman H, Lowes L, McDonald C. Respiratory function decline in eteplirsen-treated patients diverges from natural history comparators over time. Neuromusc Disord. 2018;28:P126. doi:10.1016/j.nmd.2018.06.154.

A phase II, dose finding study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of NS-065/NCNP-01 in boys with Duchenne muscular dystrophy

Authors:
Clemens P, Rao V, Connolly A, Harper A, Mah J, Smith E, McDonald C, Morgenroth L, Osaki H, Hoffman E
Citation:
Neuromusc Disord. 2018;28(Suppl 2):S67-S68. doi:10.1016/j.nmd.2018.06.156
Epub:
Not Epub
Abstract:
no abstract available
Link:
https://www.nmd-journal.com/article/S0960-8966(18)30720-X/fulltext
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Clemens P, Rao V, Connolly A, Harper A, Mah J, Smith E, McDonald C, Morgenroth L, Osaki H, Hoffman E. A phase II, dose finding study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of NS-065/NCNP-01 in boys with Duchenne muscular dystrophy. Neuromusc Disord. 2018;28(Suppl 2):S67-S68. doi:10.1016/j.nmd.2018.06.156.

Eteplirsen treatment attenuates respiratory decline in ambulatory and non-ambulatory patients with Duchenne muscular dystrophy

Authors:
Khan N, Han L, Kinane B, Gordish-Dressman H, Lowes L, McDonald C
Citation:
Neuromusc Disord. 2018;28:P125. doi:10.1016/j.nmd.2018.06.153
Epub:
Not Epub
Abstract:
no abstract available
Link:
https://www.nmd-journal.com/article/S0960-8966(18)30716-8/fulltext
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Khan N, Han L, Kinane B, Gordish-Dressman H, Lowes L, McDonald C. Eteplirsen treatment attenuates respiratory decline in ambulatory and non-ambulatory patients with Duchenne muscular dystrophy. Neuromusc Disord. 2018;28:P125. doi:10.1016/j.nmd.2018.06.153.

Eteplirsen is well tolerated in adults with mild or moderate renal impairment

Authors:
Mix C, Naughton N, Forte S
Citation:
Neuromusc Disord. 2018;28:P124. doi:10.1016/j.nmd.2018.06.152
Epub:
Not Epub
Abstract:
no abstract available
Link:
https://www.nmd-journal.com/article/S0960-8966(18)30715-6/fulltext
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Mix C, Naughton N, Forte S. Eteplirsen is well tolerated in adults with mild or moderate renal impairment. Neuromusc Disord. 2018;28:P124. doi:10.1016/j.nmd.2018.06.152.

Humoral and cell mediated immune response to new dystrophin after morpholino-induced exon skipping therapy in dystrophin-deficient mdx mice

Authors:
Nagaraju K, Vila M, Novak J, Boehler J, Hogarth M, Zhang A, Kinder T, Mazala D, Klimek MB, Fiorillo A, van den Anker J, Hathout Y, Hoffman E, Partridge T
Citation:
Neuromusc Disord. 2018;28:S90. doi:10.1016/j.nmd.2018.06.238
Epub:
Not Epub
Abstract:
Exon skipping is a promising genetic therapeutic strategy for restoring dystrophin expression in the treatment of Duchenne...
Link:
https://www.nmd-journal.com/article/S0960-8966(18)30801-0/fulltext
Organism or Cell Type:
mice mdx
Citation Extract:
Nagaraju K, Vila M, Novak J, Boehler J, Hogarth M, Zhang A, Kinder T, Mazala D, Klimek MB, Fiorillo A, van den Anker J, Hathout Y, Hoffman E, Partridge T. Humoral and cell mediated immune response to new dystrophin after morpholino-induced exon skipping therapy in dystrophin-deficient mdx mice. Neuromusc Disord. 2018;28:S90. doi:10.1016/j.nmd.2018.06.238.

Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis

Authors:
Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM
Citation:
Proc Natl Acad Sci U S A. 2018 Sep 12. pii: 201812117. doi: 10.1073/pnas.1812117115. [Epub ahead of print]
Epub:
Yes
Abstract:
The Xenopus laevis embryo has been subjected to almost saturating screens for molecules specifically expressed in dorsal...
Link:
http://www.pnas.org/content/early/2018/09/11/1812117115
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM. Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis. Proc Natl Acad Sci U S A. 2018 Sep 12. pii: 201812117. doi: 10.1073/pnas.1812117115. [Epub ahead of print].

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