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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo

Authors:
Moore C, Richens JL, Hough Y, Ucanok D, Malla S, Sang F, Chen Y, Elworthy S, Wilkinson RN, Gering M
Citation:
Blood Adv. 2018;2:2589-606. doi:10.1182/bloodadvances.2018020156
Epub:
Not Epub
Abstract:
The transcriptional repressors Gfi1(a) and Gfi1b are epigenetic regulators with unique and overlapping roles in hematopoiesis....
Link:
http://www.bloodadvances.org/content/2/20/2589
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Moore C, Richens JL, Hough Y, Ucanok D, Malla S, Sang F, Chen Y, Elworthy S, Wilkinson RN, Gering M. Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood Adv. 2018;2:2589-606. doi:10.1182/bloodadvances.2018020156.

Myogenin promotes myocyte fusion to balance fibre number and size

Authors:
Ganassi M, Badodi S, Quiroga HPO, Zammit PS, Hinits Y, Hughes SM
Citation:
Nat Comm. 2018;9:4232. doi:10.1038/s41467-018-06583-6
Epub:
Not Epub
Abstract:
Each skeletal muscle acquires its unique size before birth, when terminally differentiating myocytes fuse to form a defined...
Link:
https://www.nature.com/articles/s41467-018-06583-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ganassi M, Badodi S, Quiroga HPO, Zammit PS, Hinits Y, Hughes SM. Myogenin promotes myocyte fusion to balance fibre number and size. Nat Comm. 2018;9:4232. doi:10.1038/s41467-018-06583-6.

The microRNA, miR-18a, regulates NeuroD and photoreceptor differentiation in the retina of the zebrafish

Authors:
Taylor SM, Giuffre E, Moseley P, Hitchcock PF
Citation:
Dev Neurobiol. 2019 Jan 7. doi: 10.1002/dneu.22666. [Epub ahead of print]
Epub:
Yes
Abstract:
During embryonic retinal development, six types of retinal neurons are generated from multipotent progenitors in a strict...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/dneu.22666
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Taylor SM, Giuffre E, Moseley P, Hitchcock PF. The microRNA, miR-18a, regulates NeuroD and photoreceptor differentiation in the retina of the zebrafish. Dev Neurobiol. 2019 Jan 7. doi: 10.1002/dneu.22666. [Epub ahead of print].

Embryonic myosin is a regeneration marker to monitor utrophin based therapies for DMD

Authors:
Guiraud S, Edwards B, Squire SE, Moir L, Berg A, Babbs A, Ramadan N, Wood MJ, Davies KE
Citation:
Hum Mol Genet. 2018;ddy353 doi:10.1093/hmg/ddy353
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is a lethal, X-linked muscle-wasting disease caused by lack of the cytoskeletal protein...
Link:
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddy353/5124574
Delivery Method:
peptide-linked
Organism or Cell Type:
mice mdx
Citation Extract:
Guiraud S, Edwards B, Squire SE, Moir L, Berg A, Babbs A, Ramadan N, Wood MJ, Davies KE. Embryonic myosin is a regeneration marker to monitor utrophin based therapies for DMD. Hum Mol Genet. 2018;ddy353 doi:10.1093/hmg/ddy353 .

Evaluation of the Effect of 2’-O-Methyl, Fluoro Hexitol, Bicyclo and Morpholino Nucleic Acid Modifications on Potency of GalNAc Conjugated Antisense Oligonucleotides in Mice

Authors:
Prakash TP, Yu J, Kinberger GA, Low A, Jackson M, Rigo F, Swayze EE, Seth PP
Citation:
Bioorg Med Chem Lett. 2018;[Epub ahead of print] doi:10.1016/j.bmcl.2018.10.011
Epub:
Not Epub
Abstract:
The potency of antisense oligonucleotide (ASO) drugs has significantly improved in the clinic after exploiting...
Link:
https://www.sciencedirect.com/science/article/pii/S0960894X18308011
Delivery Method:
GalNAc-linked
Organism or Cell Type:
mice
Citation Extract:
Prakash TP, Yu J, Kinberger GA, Low A, Jackson M, Rigo F, Swayze EE, Seth PP. Evaluation of the Effect of 2’-O-Methyl, Fluoro Hexitol, Bicyclo and Morpholino Nucleic Acid Modifications on Potency of GalNAc Conjugated Antisense Oligonucleotides in Mice. Bioorg Med Chem Lett. 2018;[Epub ahead of print] doi:10.1016/j.bmcl.2018.10.011.

ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis

Authors:
Song EK, Jeon J, Jang DG, Kim HE, Sim HJ, Kwon KY, Medina-Ruiz S, Jang H-J, Lee AR, Rho JG, Lee H-S, Kim SJ, Park CY, Myung K, Kim W, Kwon T, Yang S, Park TJ
Citation:
Sci Translat Med. 2018;10(462):eaam7486 doi:10.1126/scitranslmed.aam7486
Epub:
Not Epub
Abstract:
Developing and mature chondrocytes constantly interact with and remodel the surrounding extracellular matrix (ECM). Recent...
Link:
http://stm.sciencemag.org/content/10/462/eaam7486
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Song EK, Jeon J, Jang DG, Kim HE, Sim HJ, Kwon KY, Medina-Ruiz S, Jang H-J, Lee AR, Rho JG, Lee H-S, Kim SJ, Park CY, Myung K, Kim W, Kwon T, Yang S, Park TJ. ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis. Sci Translat Med. 2018;10(462):eaam7486 doi:10.1126/scitranslmed.aam7486 .

Evaluation of the estrogen receptor alpha as a possible target of bifenthrin effects in the estrogenic and dopaminergic signaling pathways in zebrafish embryos

Authors:
Becker Bertotto L, Dasgupta S, Vliet S, Dudley S, Gan J, Volz DC, Schlenk D
Citation:
Sci Total Environ. 2019;651(pt.2):2424-2431. doi:10.1016/j.scitotenv.2018.10.079
Epub:
Not Epub
Abstract:
Bifenthrin (BF) is a pyrethroid insecticide widely used in urban and agricultural applications. Previous studies in embryos of...
Link:
https://www.sciencedirect.com/science/article/pii/S0048969718339524
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Becker Bertotto L, Dasgupta S, Vliet S, Dudley S, Gan J, Volz DC, Schlenk D. Evaluation of the estrogen receptor alpha as a possible target of bifenthrin effects in the estrogenic and dopaminergic signaling pathways in zebrafish embryos. Sci Total Environ. 2019;651(pt.2):2424-2431. doi:10.1016/j.scitotenv.2018.10.079.

CAV1 regulates primordial follicle formation via the Notch2 signalling pathway and is associated with premature ovarian insufficiency in humans

Authors:
Huang K, Dang Y, Zhang P, Shen C, Sui X, Xia G, Qin Y, Jiao X, Wang C, Huo R, Chen Z-J
Citation:
Hum Reprod. 2018;dey299. doi:10.1093/humrep/dey299
Epub:
Not Epub
Abstract:
STUDY QUESTION: What is the function of CAV1 in folliculogenesis and female reproduction? SUMMARY ANSWER: CAV1 regulates...
Link:
https://academic.oup.com/humrep/advance-article-abstract/doi/10.1093/humrep/dey299/5124569
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse ovary
Citation Extract:
Huang K, Dang Y, Zhang P, Shen C, Sui X, Xia G, Qin Y, Jiao X, Wang C, Huo R, Chen Z-J. CAV1 regulates primordial follicle formation via the Notch2 signalling pathway and is associated with premature ovarian insufficiency in humans. Hum Reprod. 2018;dey299. doi:10.1093/humrep/dey299.

The Ric-8A/Gα13/FAK signaling cascade controls focal adhesion formation during neural crest cell migration

Authors:
Toro-Tapia G, Villaseca S, Beyer A, Roycroft A, Marcellini S, Mayor R, Torrejón M
Citation:
Development. 2018 Oct 8. pii: dev.164269. doi: 10.1242/dev.164269. [Epub ahead of print]
Epub:
Yes
Abstract:
Ric-8A is a pleiotropic guanine nucleotide exchange factor involved the activation of various heterotrimeric G protein pathways...
Link:
http://dev.biologists.org/content/early/2018/10/05/dev.164269.long
Citation Extract:
Toro-Tapia G, Villaseca S, Beyer A, Roycroft A, Marcellini S, Mayor R, Torrejón M. The Ric-8A/Gα13/FAK signaling cascade controls focal adhesion formation during neural crest cell migration. Development. 2018 Oct 8. pii: dev.164269. doi: 10.1242/dev.164269. [Epub ahead of print].

Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson

Authors:
De Robertis EM, Moriyama Y, Colozza G
Citation:
Dev Growth Differ. 2017 Sep;59(7):580-592. doi: 10.1111/dgd.12388. Epub 2017 Aug 16
Epub:
Not Epub
Abstract:
The classic book "On Growth and Form" by naturalist D'Arcy Thompson was published 100 years ago. To celebrate...
Link:
https://onlinelibrary.wiley.com/doi/pdf/10.1111/dgd.12388
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
De Robertis EM, Moriyama Y, Colozza G. Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson. Dev Growth Differ. 2017 Sep;59(7):580-592. doi: 10.1111/dgd.12388. Epub 2017 Aug 16.

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