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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Loss of cep57 function induces G1 arrest and microcephaly

Authors:
Iyer S, Gokhale A, Shree Murugesan P, Kumar M
Citation:
bioRxiv [preprint] 2025.04.10.648303; doi: https://doi.org/10.1101/2025.04.10.648303
Epub:
Not Epub
Abstract:
Centrosomal protein 57 (CEP57) is essential for centrosome organization, regulating nucleation and stabilization of...
Link:
https://www.biorxiv.org/content/10.1101/2025.04.10.648303v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Iyer S, Gokhale A, Shree Murugesan P, Kumar M. Loss of cep57 function induces G1 arrest and microcephaly. bioRxiv [preprint] 2025.04.10.648303; doi: https://doi.org/10.1101/2025.04.10.648303.

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing

Authors:
Morales Castro RA, Kern BC, Díaz-Basabe A, Meinen ER, Zhao D, Zhou Y, Castillo F, Monasterio G, Farcas V, Chávez MN, Fransson J, Villablanca EJ
Citation:
Mucosal Immunol. 2025 Apr 17:S1933-0219(25)00042-X. doi: 10.1016/j.mucimm.2025.04.004. Epub ahead of print. PMID: 40252728
Epub:
Not Epub
Abstract:
Promoting intestinal regeneration and enhancing mucosal healing have emerged as promising therapeutic alternatives for treating...
Link:
https://www.sciencedirect.com/science/article/pii/S193302192500042X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Morales Castro RA, Kern BC, Díaz-Basabe A, Meinen ER, Zhao D, Zhou Y, Castillo F, Monasterio G, Farcas V, Chávez MN, Fransson J, Villablanca EJ. A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing. Mucosal Immunol. 2025 Apr 17:S1933-0219(25)00042-X. doi: 10.1016/j.mucimm.2025.04.004. Epub ahead of print. PMID: 40252728.

Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases

Authors:
Gentile GM, Blue RE, Goda GA, Guzman BB, Szymanski RA, Lee EY, Engels NM, Hinkle ER, Wiedner HJ, Bishop AN, Harrison JT, Zhang H, Wehrens XHT, Dominguez D, Giudice J
Citation:
RNA Biol. 2025 Apr 10. doi: 10.1080/15476286.2025.2491160. Epub ahead of print. PMID: 40207498
Epub:
Not Epub
Abstract:
The reprogramming of alternative splicing networks during development is a hallmark of tissue maturation and identity....
Link:
https://www.tandfonline.com/doi/full/10.1080/15476286.2025.2491160
Delivery Method:
electroporation
Organism or Cell Type:
C2C12 myoblast cells
Citation Extract:
Gentile GM, Blue RE, Goda GA, Guzman BB, Szymanski RA, Lee EY, Engels NM, Hinkle ER, Wiedner HJ, Bishop AN, Harrison JT, Zhang H, Wehrens XHT, Dominguez D, Giudice J. Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases. RNA Biol. 2025 Apr 10. doi: 10.1080/15476286.2025.2491160. Epub ahead of print. PMID: 40207498.

Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy

Authors:
Dogra D, Phan VA, Zhang S, Gavrilovici C, DiMarzo N, Narang A, Ibhazehiebo K, Kurrasch DM
Citation:
PLoS Biol. 2025 Apr 10;23(4):e3002499. doi: 10.1371/journal.pbio.3002499. Epub ahead of print. PMID: 40208862
Epub:
Not Epub
Abstract:
SLC13A5 encodes a citrate transporter highly expressed in the brain and is important for regulating intra- and extracellular...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002499
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dogra D, Phan VA, Zhang S, Gavrilovici C, DiMarzo N, Narang A, Ibhazehiebo K, Kurrasch DM. Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy. PLoS Biol. 2025 Apr 10;23(4):e3002499. doi: 10.1371/journal.pbio.3002499. Epub ahead of print. PMID: 40208862.

Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice

Authors:
Liu DH, Li F, Yang RZ, Wu Z, Meng XY, Li SM, Li WX, Li JK, Wang DD, Wang RY, Li SA, Liu PP, Kang JS
Citation:
Cell Commun Signal. 2025 Apr 8;23(1):174. doi: 10.1186/s12964-025-02141-y. PMID: 40200300; PMCID: PMC11980072
Epub:
Not Epub
Abstract:
STX12 (syntaxin12 or syntaxin13), a member of the SNARE protein family, plays a crucial role in intracellular vesicle transport...
Link:
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-025-02141-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu DH, Li F, Yang RZ, Wu Z, Meng XY, Li SM, Li WX, Li JK, Wang DD, Wang RY, Li SA, Liu PP, Kang JS. Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice. Cell Commun Signal. 2025 Apr 8;23(1):174. doi: 10.1186/s12964-025-02141-y. PMID: 40200300; PMCID: PMC11980072.

Conception and synthesis of sequence-coded morpholinos

Authors:
Pousse B, Al Ouahabi A, Baxter PNW, Charles L, Lutz JF
Citation:
Chemistry. 2025 Apr 14:e202501161. doi: 10.1002/chem.202501161. Epub ahead of print. PMID: 40227092
Epub:
Not Epub
Abstract:
Solid-phase morpholino chemistry was explored as a new route to synthesize abiological sequence-defined oligomers. Two...
Link:
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202501161
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Pousse B, Al Ouahabi A, Baxter PNW, Charles L, Lutz JF. Conception and synthesis of sequence-coded morpholinos. Chemistry. 2025 Apr 14:e202501161. doi: 10.1002/chem.202501161. Epub ahead of print. PMID: 40227092.

The cohesin-associated protein Pds5A governs the meiotic spindle assembly via deubiquitination of Kif5B in oocytes

Authors:
Zhang Y, Bai J, Xiong B
Citation:
Sci Adv. 2025 Apr 11;11(15):eadt6159. doi: 10.1126/sciadv.adt6159. Epub 2025 Apr 11. PMID: 40215310; PMCID: PMC11988415
Epub:
Not Epub
Abstract:
Chromosome cohesion mediated by cohesin complex and its associated proteins is required for accurate chromosome segregation and...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11988415/
Delivery Method:
microinjection
Organism or Cell Type:
ICR mouse oocyst
Citation Extract:
Zhang Y, Bai J, Xiong B. The cohesin-associated protein Pds5A governs the meiotic spindle assembly via deubiquitination of Kif5B in oocytes. Sci Adv. 2025 Apr 11;11(15):eadt6159. doi: 10.1126/sciadv.adt6159. Epub 2025 Apr 11. PMID: 40215310; PMCID: PMC11988415.

Far-red fluorescent genetically encoded calcium ion indicators

Authors:
Dalangin R, Jia BZ, Qi Y, Aggarwal A, Sakoi K, Drobizhev M, Molina RS, Patel R, Abdelfattah AS, Zheng J, Reep D, Hasseman JP; GENIE Project Team; Zhao Y, Wu J, Podgorski K, Tebo AG, Schreiter ER, Hughes TE, Terai T, Paquet ME, Megason SG, Cohen AE, Shen Y, Campbell RE
Citation:
Nat Commun. 2025 Apr 7;16(1):3318. doi: 10.1038/s41467-025-58485-z. PMID: 40195305
Epub:
Not Epub
Abstract:
Genetically encoded calcium ion (Ca2+) indicators (GECIs) are widely-used molecular tools for functional imaging of Ca2+...
Link:
https://www.nature.com/articles/s41467-025-58485-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dalangin R, Jia BZ, Qi Y, Aggarwal A, Sakoi K, Drobizhev M, Molina RS, Patel R, Abdelfattah AS, Zheng J, Reep D, Hasseman JP; GENIE Project Team; Zhao Y, Wu J, Podgorski K, Tebo AG, Schreiter ER, Hughes TE, Terai T, Paquet ME, Megason SG, Cohen AE, Shen Y, Campbell RE. Far-red fluorescent genetically encoded calcium ion indicators. Nat Commun. 2025 Apr 7;16(1):3318. doi: 10.1038/s41467-025-58485-z. PMID: 40195305.

Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis

Authors:
Leon-Icaza SA, Frétaud M, Cornélie S, Bureau C, Yatime L, Floto RA, Renshaw SA, Herrmann JL, Langevin C, Cougoule C, Bernut A
Citation:
Biomed Pharmacother. 2025 Mar 31;186:117957. doi: 10.1016/j.biopha.2025.117957. Epub ahead of print. PMID: 40168724
Epub:
Not Epub
Abstract:
Background: Overactive neutrophilic inflammation causes damage to the airways and death in people with cystic fibrosis (CF), a...
Link:
https://www.sciencedirect.com/science/article/pii/S0753332225001519
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Leon-Icaza SA, Frétaud M, Cornélie S, Bureau C, Yatime L, Floto RA, Renshaw SA, Herrmann JL, Langevin C, Cougoule C, Bernut A. Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis. Biomed Pharmacother. 2025 Mar 31;186:117957. doi: 10.1016/j.biopha.2025.117957. Epub ahead of print. PMID: 40168724.

Probe-Screened Carbon Nanotube Field-Effect Transistor Biosensor to Enhance Breast Cancer-Related Gene Assay

Authors:
Liu P, Liu Y, Cai B, Li J, Zhang G-J
Citation:
Green Analytical Chemistry (2025) 100267, ISSN 2772-5774, doi.org/10.1016/j.greeac.2025.100267
Epub:
Not Epub
Abstract:
BRCA1 gene testing is a trump card for liquid biopsy and early diagnosis in breast cancer, which has been limited, however, by...
Link:
/www.sciencedirect.com/science/article/pii/S2772577425000631
Delivery Method:
None
Organism or Cell Type:
DNA samples extracted from BRCA1-mutated breast cancer patients and healthy controls
Citation Extract:
Liu P, Liu Y, Cai B, Li J, Zhang G-J. Probe-Screened Carbon Nanotube Field-Effect Transistor Biosensor to Enhance Breast Cancer-Related Gene Assay. Green Analytical Chemistry (2025) 100267, ISSN 2772-5774, doi.org/10.1016/j.greeac.2025.100267.

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