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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Eteplirsen treatment for Duchenne muscular dystrophy: Exon skipping and dystrophin production

Authors:
Charleston JS, Schnell FJ, Dworzak J, Donoghue C, Lewis S, Chen L, Young GD, Milici AJ, Voss J, DeAlwis U, Wentworth B, Rodino-Klapac LR, Sahenk Z, Frank D, Mendell JR
Citation:
Neurology. 2018 May 11. pii: 10.1212/WNL.0000000000005680. doi: 10.1212/WNL.0000000000005680. [Epub ahead of print]
Epub:
Yes
Abstract:
OBJECTIVE: To describe the quantification of novel dystrophin production in patients with Duchenne muscular dystrophy (DMD)...
Link:
http://n.neurology.org/content/early/2018/05/11/WNL.0000000000005680.long
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Charleston JS, Schnell FJ, Dworzak J, Donoghue C, Lewis S, Chen L, Young GD, Milici AJ, Voss J, DeAlwis U, Wentworth B, Rodino-Klapac LR, Sahenk Z, Frank D, Mendell JR. Eteplirsen treatment for Duchenne muscular dystrophy: Exon skipping and dystrophin production. Neurology. 2018 May 11. pii: 10.1212/WNL.0000000000005680. doi: 10.1212/WNL.0000000000005680. [Epub ahead of print].

Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain

Authors:
Addison M, Xu Q, Cayuso J, Wilkinson DG
Citation:
Dev Cell. 2018 Apr 30. pii: S1534-5807(18)30278-8. doi: 10.1016/j.devcel.2018.04.003. [Epub ahead of print]
Epub:
Yes
Abstract:
The patterning of tissues to form subdivisions with distinct and homogeneous regional identity is potentially disrupted by cell...
Link:
https://www.sciencedirect.com/science/article/pii/S1534580718302788
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Addison M, Xu Q, Cayuso J, Wilkinson DG. Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain. Dev Cell. 2018 Apr 30. pii: S1534-5807(18)30278-8. doi: 10.1016/j.devcel.2018.04.003. [Epub ahead of print].

A noncanonical function of histidyl-tRNA synthetase: inhibition of vascular hyperbranching during zebrafish development

Authors:
Ni R, Luo L
Citation:
FEBS Open Bio. 2018 Apr 17;8(5):722-731. doi: 10.1002/2211-5463.12420. eCollection 2018 May
Epub:
Not Epub
Abstract:
Histidyl-tRNA synthetase (Hars) catalyzes the ligation of histidine residues to cognate tRNA. Here, we demonstrate a...
Link:
https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/2211-5463.12420
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ni R, Luo L. A noncanonical function of histidyl-tRNA synthetase: inhibition of vascular hyperbranching during zebrafish development. FEBS Open Bio. 2018 Apr 17;8(5):722-731. doi: 10.1002/2211-5463.12420. eCollection 2018 May.

Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in mice

Authors:
Zheng B, Gao T, Yu J, Guo Y, Shen C, Zhang X, Li H, Huang X
Citation:
Reproduction. 2018 May 9. pii: REP-17-0666. doi: 10.1530/REP-17-0666. [Epub ahead of print]
Epub:
Yes
Abstract:
The cellular nucleic acid-binding protein (CNBP), also known as zinc finger protein 9 (ZNF9), is a highly conserved zinc finger...
Link:
http://www.reproduction-online.org/content/early/2018/05/09/REP-17-0666.abstract
Organism or Cell Type:
explant: mouse neonatal testis culture
Citation Extract:
Zheng B, Gao T, Yu J, Guo Y, Shen C, Zhang X, Li H, Huang X. Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in mice. Reproduction. 2018 May 9. pii: REP-17-0666. doi: 10.1530/REP-17-0666. [Epub ahead of print].

Estrogenic mechanisms and cardiac responses following early life exposure to Bisphenol A (BPA) and its metabolite 4-methyl-2,4-bis(p-hydroxyphenyl)pent-1-ene (MBP) in zebrafish

Authors:
Moreman J, Takesono A, Trznadel M, Winter M, Perry A, Wood M, Rogers NJ, Kudoh T, Tyler CR
Citation:
Environ Sci Technol. 2018 May 8. doi: 10.1021/acs.est.8b01095. [Epub ahead of print]
Epub:
Yes
Abstract:
Environmental exposure to Bisphenol A (BPA) has been associated with a range of adverse health effects, including on the...
Link:
https://pubs.acs.org/doi/10.1021/acs.est.8b01095
Organism or Cell Type:
zebrafish
Citation Extract:
Moreman J, Takesono A, Trznadel M, Winter M, Perry A, Wood M, Rogers NJ, Kudoh T, Tyler CR. Estrogenic mechanisms and cardiac responses following early life exposure to Bisphenol A (BPA) and its metabolite 4-methyl-2,4-bis(p-hydroxyphenyl)pent-1-ene (MBP) in zebrafish. Environ Sci Technol. 2018 May 8. doi: 10.1021/acs.est.8b01095. [Epub ahead of print].

Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish

Authors:
Zecchin A, Wong B, Tembuyser B, Souffreau J, Van Nuffelen A, Wyns S, Vinckier S, Carmeliet P, Dewerchin M
Citation:
Biochem Biophys Res Commun. 2018 May 3. pii: S0006-291X(18)31037-4. doi: 10.1016/j.bbrc.2018.04.233. [Epub ahead of print]
Epub:
Yes
Abstract:
During embryonic development, lymphatic endothelial cells (LECs) differentiate from venous endothelial cells (VECs), a process...
Link:
https://www.ncbi.nlm.nih.gov/pubmed/29730294
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zecchin A, Wong B, Tembuyser B, Souffreau J, Van Nuffelen A, Wyns S, Vinckier S, Carmeliet P, Dewerchin M. Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish. Biochem Biophys Res Commun. 2018 May 3. pii: S0006-291X(18)31037-4. doi: 10.1016/j.bbrc.2018.04.233. [Epub ahead of print].

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy

Authors:
Burns DT, Donkervoort S, Müller JS, Knierim E, Bharucha-Goebel D, Faqeih EA, Bell SK, AlFaifi AY, Monies D, Millan F, Retterer K, Dyack S, MacKay S, Morales-Gonzalez S, Giunta M, Munro B, Hudson G, Scavina M, Baker L, Massini TC, Lek M, Hu Y, Ezzo D, AlKuraya FS, Kang PB, Griffin H, Foley AR, Schuelke M, Horvath R, Bönnemann CG
Citation:
Am J Hum Genet. 2018 May 3;102(5):858-873. doi: 10.1016/j.ajhg.2018.03.011
Epub:
Not Epub
Abstract:
The exosome is a conserved multi-protein complex that is essential for correct RNA processing. Recessive variants in exosome...
Link:
https://www.cell.com/ajhg/fulltext/S0002-9297(18)30100-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Burns DT, Donkervoort S, Müller JS, Knierim E, Bharucha-Goebel D, Faqeih EA, Bell SK, AlFaifi AY, Monies D, Millan F, Retterer K, Dyack S, MacKay S, Morales-Gonzalez S, Giunta M, Munro B, Hudson G, Scavina M, Baker L, Massini TC, Lek M, Hu Y, Ezzo D, AlKuraya FS, Kang PB, Griffin H, Foley AR, Schuelke M, Horvath R, Bönnemann CG. Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy. Am J Hum Genet. 2018 May 3;102(5):858-873. doi: 10.1016/j.ajhg.2018.03.011.

Temporal and Spatial Post-Transcriptional Regulation of Zebrafish Tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly

Authors:
Chowdhury TA, Koceja C, Eisa-Beygi S, Kleinstiver BP, Kumar SN, Lin CW, Li K, Prabhudesai S, Joung JK, Ramchandran R
Citation:
Arterioscler Thromb Vasc Biol. 2018 May 3. pii: ATVBAHA.118.310848. doi: 10.1161/ATVBAHA.118.310848. [Epub ahead of print]
Epub:
Yes
Abstract:
OBJECTIVE: Tie1 (tyrosine kinase containing immunoglobulin and epidermal growth factor homology 1), an endothelial and...
Link:
http://atvb.ahajournals.org/content/early/2018/05/02/ATVBAHA.118.310848.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chowdhury TA, Koceja C, Eisa-Beygi S, Kleinstiver BP, Kumar SN, Lin CW, Li K, Prabhudesai S, Joung JK, Ramchandran R. Temporal and Spatial Post-Transcriptional Regulation of Zebrafish Tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly. Arterioscler Thromb Vasc Biol. 2018 May 3. pii: ATVBAHA.118.310848. doi: 10.1161/ATVBAHA.118.310848. [Epub ahead of print].

CTCF knockout reveals an essential role for this protein during the zebrafish development

Authors:
Carmona-Aldana F, Zampedri C, Suaste-Olmos F, Murillo-de-Ozores A, Guerrero G, Arzate-Mejía R, Maldonado E, Navarro R, Chimal-Monroy J, Recillas-Targa F
Citation:
Mech Dev. 2018 May 1. pii: S0925-4773(18)30011-X. doi: 10.1016/j.mod.2018.04.006. [Epub ahead of print]
Epub:
Yes
Abstract:
Chromatin regulation and organization are essential processes that regulate gene activity. The CCCTC-binding factor (CTCF) is a...
Link:
https://www.sciencedirect.com/science/article/pii/S092547731830011X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Carmona-Aldana F, Zampedri C, Suaste-Olmos F, Murillo-de-Ozores A, Guerrero G, Arzate-Mejía R, Maldonado E, Navarro R, Chimal-Monroy J, Recillas-Targa F. CTCF knockout reveals an essential role for this protein during the zebrafish development. Mech Dev. 2018 May 1. pii: S0925-4773(18)30011-X. doi: 10.1016/j.mod.2018.04.006. [Epub ahead of print].

Efficient exon skipping of SGCG mutations mediated by phosphorodiamidate morpholino oligomers

Authors:
Wyatt EJ, Demonbreun AR, Kim EY, Puckelwartz MJ, Vo AH, Dellefave-Castillo LM, Gao QQ, Vainzof M, Pavanello RCM, Zatz M, McNally EM
Citation:
JCI Insight. 2018 May 3;3(9). pii: 99357. doi: 10.1172/jci.insight.99357. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Exon skipping uses chemically modified antisense oligonucleotides to modulate RNA splicing. Therapeutically, exon skipping can...
Link:
https://insight.jci.org/articles/view/99357
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human primary fibroblasts differentiated to myogenic cells
Citation Extract:
Wyatt EJ, Demonbreun AR, Kim EY, Puckelwartz MJ, Vo AH, Dellefave-Castillo LM, Gao QQ, Vainzof M, Pavanello RCM, Zatz M, McNally EM. Efficient exon skipping of SGCG mutations mediated by phosphorodiamidate morpholino oligomers. JCI Insight. 2018 May 3;3(9). pii: 99357. doi: 10.1172/jci.insight.99357. [Epub ahead of print].

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