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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides

Authors:
Ahmed K, Aoki Y, Koo T, McClorey G, Benner L, Coenen-Stass A, O'Donovan L, Lehto T, Garciaguerra A, Nordin JZ, Saleh AF, Behlke MA, Morris , Goyenvalle A, Dugovic B, Leumann CJ, Gordon S, Gait MJ, El-Andaloussi S, Wood MJA
Citation:
Nano Lett. 2015;[Epub ahead of print] doi:10.1021/acs.nanolett.5b00490
Epub:
Yes
Abstract:
Antisense oligonucleotides (ASOs) have the potential of revolutionizing medicine due to their ability to manipulate gene...
Link:
http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.5b00490
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture, mice
Citation Extract:
Ahmed K, Aoki Y, Koo T, McClorey G, Benner L, Coenen-Stass A, O'Donovan L, Lehto T, Garciaguerra A, Nordin JZ, Saleh AF, Behlke MA, Morris , Goyenvalle A, Dugovic B, Leumann CJ, Gordon S, Gait MJ, El-Andaloussi S, Wood MJA. Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides. Nano Lett. 2015;[Epub ahead of print] doi:10.1021/acs.nanolett.5b00490.

NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells

Authors:
Fantin A, Lampropoulou A, Gestri G, Raimondi C, Senatore V, Zachary I, Ruhrberg C
Citation:
Cell Rep. 2015 doi:10.1016/j.celrep.2015.05.018
Epub:
Not Epub
Abstract:
Sprouting blood vessels are led byfilopodia-studded endothelial tip cells that respond to angiogenic signals. Mosaic lineage...
Link:
http://www.cell.com/cell-reports/abstract/S2211-1247%2815%2900530-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fantin A, Lampropoulou A, Gestri G, Raimondi C, Senatore V, Zachary I, Ruhrberg C. NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell Rep. 2015 doi:10.1016/j.celrep.2015.05.018.

The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression

Authors:
Ma Y, Liu X, Liu1 Z, Wei S, Shang H, Xue Y, Cao Y, Meng A, Wang Q
Citation:
J Neurosci. 2015; 35(22):8493-506. doi:10.1523/JNEUROSCI.0377-15.2015
Epub:
Not Epub
Abstract:
During vertebrate embryogenesis, the neuroectoderm is induced from dorsal ectoderm and then partitioned into anterior and...
Link:
http://www.jneurosci.org/content/35/22/8493.abstract
Organism or Cell Type:
zebrafish
Citation Extract:
Ma Y, Liu X, Liu1 Z, Wei S, Shang H, Xue Y, Cao Y, Meng A, Wang Q. The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. J Neurosci. 2015; 35(22):8493-506. doi:10.1523/JNEUROSCI.0377-15.2015.

A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect

Authors:
Hsu CH, Lin JS, Po Lai K, Li JW, Chan TF, You MS, Tse WK, Jiang YJ
Citation:
Sci Rep. 2015 Jun 3;5:10673. doi: 10.1038/srep10673
Epub:
Not Epub
Abstract:
mibnn2002, found from an allele screen, showed early segmentation defect and severe cell death phenotypes, which are different...
Link:
http://www.nature.com/srep/2015/150603/srep10673/full/srep10673.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hsu CH, Lin JS, Po Lai K, Li JW, Chan TF, You MS, Tse WK, Jiang YJ. A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Sci Rep. 2015 Jun 3;5:10673. doi: 10.1038/srep10673.

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation

Authors:
Mercurio S, Petrillo S, Chiabrando D, Bassi ZI, Gays D, Camporeale A, Vacaru A, Miniscalco B, Valperga G, Silengo L, Altruda F, Baron MH, Santoro MM, Tolosano E
Citation:
Haematologica. 2015 Jun;100(6):720-9. doi: 10.3324/haematol.2014.114488. Epub 2015 Mar 20
Epub:
Not Epub
Abstract:
Feline leukemia virus subgroup C receptor 1 (Flvcr1) encodes two heme exporters: FLVCR1a, which localizes to the plasma...
Link:
http://www.haematologica.org/content/100/6/720
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mercurio S, Petrillo S, Chiabrando D, Bassi ZI, Gays D, Camporeale A, Vacaru A, Miniscalco B, Valperga G, Silengo L, Altruda F, Baron MH, Santoro MM, Tolosano E. The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Haematologica. 2015 Jun;100(6):720-9. doi: 10.3324/haematol.2014.114488. Epub 2015 Mar 20.

Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish

Authors:
Bhatia S, Gordon CT, Foster RG, Melin L, Abadie V, Baujat G, Vazquez MP, Amiel J, Lyonnet S, Heyningen Vv, Kleinjan DA
Citation:
PLoS Genet. 2015 Jun 1;11(6):e1005193. doi: 10.1371/journal.pgen.1005193. eCollection 2015 Jun
Epub:
Not Epub
Abstract:
Disruption of gene regulation by sequence variation in non-coding regions of the genome is now recognised as a significant...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005193
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bhatia S, Gordon CT, Foster RG, Melin L, Abadie V, Baujat G, Vazquez MP, Amiel J, Lyonnet S, Heyningen Vv, Kleinjan DA. Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish. PLoS Genet. 2015 Jun 1;11(6):e1005193. doi: 10.1371/journal.pgen.1005193. eCollection 2015 Jun.

Knockdown of central ghrelin O-acyltransferase by vivo-morpholino reduces body mass of rats fed a high-fat diet

Authors:
Wellman M, Abizaid A
Citation:
Peptides. 2015 May 28. pii: S0196-9781(15)00163-1. doi: 10.1016/j.peptides.2015.05.007. [Epub ahead of print]
Epub:
Yes
Abstract:
The enzyme ghrelin O-acyltransferase (GOAT) activates the orexigenic peptide ghrelin by transferring an acyl group from fatty...
Link:
http://www.sciencedirect.com/science/article/pii/S0196978115001631
Delivery Method:
Vivo-Morpholino i.c.v.
Organism or Cell Type:
rat
Citation Extract:
Wellman M, Abizaid A. Knockdown of central ghrelin O-acyltransferase by vivo-morpholino reduces body mass of rats fed a high-fat diet. Peptides. 2015 May 28. pii: S0196-9781(15)00163-1. doi: 10.1016/j.peptides.2015.05.007. [Epub ahead of print].

Loss of Function Mutations in NNT Are Associated with Left Ventricular Noncompaction

Authors:
Bainbridge MN, Davis EE, Choi WY, Dickson A, Martinez HR, Wang M, Dinh H, Muzny D, Pignatelli R, Katsanis N, Boerwinkle E, Gibbs R, Jefferies JL
Citation:
Circ Cardiovasc Genet. 2015 May 29. pii: CIRCGENETICS.115.001026. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Left ventricular noncompaction (LVNC) is an autosomal dominant, genetically heterogeneous cardiomyopathy with...
Link:
http://circgenetics.ahajournals.org/content/early/2015/05/29/CIRCGENETICS.115.001026.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bainbridge MN, Davis EE, Choi WY, Dickson A, Martinez HR, Wang M, Dinh H, Muzny D, Pignatelli R, Katsanis N, Boerwinkle E, Gibbs R, Jefferies JL. Loss of Function Mutations in NNT Are Associated with Left Ventricular Noncompaction. Circ Cardiovasc Genet. 2015 May 29. pii: CIRCGENETICS.115.001026. [Epub ahead of print].

Id2a is required for hepatic outgrowth during liver development in zebrafish

Authors:
Khaliq M, Choi TY, So J, Shin D
Citation:
Mech Dev. 2015 May 27. pii: S0925-4773(15)00043-X. doi: 10.1016/j.mod.2015.05.001. [Epub ahead of print]
Epub:
Yes
Abstract:
During development, inhibitor of DNA binding (Id) proteins, a subclass of the helix-loop-helix family of proteins, regulate...
Link:
http://www.sciencedirect.com/science/article/pii/S092547731500043X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Khaliq M, Choi TY, So J, Shin D. Id2a is required for hepatic outgrowth during liver development in zebrafish. Mech Dev. 2015 May 27. pii: S0925-4773(15)00043-X. doi: 10.1016/j.mod.2015.05.001. [Epub ahead of print].

eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference

Authors:
Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Güttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G
Citation:
Nat Comm. 2015;6:7194. doi:10.1038/ncomms8194
Epub:
Not Epub
Abstract:
MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expression in eukaryotes. Here we...
Link:
http://www.nature.com/ncomms/2015/150528/ncomms8194/full/ncomms8194.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Güttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Comm. 2015;6:7194. doi:10.1038/ncomms8194.

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