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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish

Authors:
Shen X, Liu F, Wang Y, Wang H, Ma J, Xia W, Zhang J, Jiang N, Sun S, Wang X, Ma D
Citation:
Int J Dev Biol. 2015;59(4-5-6):195-203
Epub:
Not Epub
Abstract:
Hearing defects can significantly influence quality of life for those who experience them. At this time, 177 deafness genes...
Link:
http://www.ijdb.ehu.es/web/paper/140200md/down-regulation-of-msrb3-and-destruction-of-normal-auditory-system-development-through-hair-cell-apoptosis-in-zebrafish
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shen X, Liu F, Wang Y, Wang H, Ma J, Xia W, Zhang J, Jiang N, Sun S, Wang X, Ma D. Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish. Int J Dev Biol. 2015;59(4-5-6):195-203.

Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone

Authors:
Jepps TA, Carr G, Lundegaard PR, Olesen SP, Greenwood IA
Citation:
J Physiol. 2015 Oct 27. doi: 10.1113/JP271286. [Epub ahead of print]
Epub:
Yes
Abstract:
KEY POINTS: KCNE4 alters the biophysical properties and cellular localisation of Kv7.4. KCNE4 is expressed in a variety of...
Link:
http://onlinelibrary.wiley.com/doi/10.1113/JP271286/abstract
Delivery Method:
Lipofectamine 2000
Citation Extract:
Jepps TA, Carr G, Lundegaard PR, Olesen SP, Greenwood IA. Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone. J Physiol. 2015 Oct 27. doi: 10.1113/JP271286. [Epub ahead of print].

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base

Authors:
Wang WJ, Tay HG, Soni R, Perumal GS, Goll MG, Macaluso FP, Asara JM, Amack JD, Tsou MF
Citation:
Nat Cell Biol. 2013 Jun;15(6):591-601. doi: 10.1038/ncb2739. Epub 2013 May 5
Epub:
Not Epub
Abstract:
The transition zone is a specialized compartment found at the base of cilia, adjacent to the centriole distal end, where...
Link:
http://www.nature.com/ncb/journal/v15/n6/full/ncb2739.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang WJ, Tay HG, Soni R, Perumal GS, Goll MG, Macaluso FP, Asara JM, Amack JD, Tsou MF. CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base. Nat Cell Biol. 2013 Jun;15(6):591-601. doi: 10.1038/ncb2739. Epub 2013 May 5.

Morpholinos: Antisense and Sensibility

Authors:
Blum M, De Robertis EM, Wallingford JB, Niehrs C
Citation:
Dev Cell. 2015;35(2):145-9. doi:10.1016/j.devcel.2015.09.017
Epub:
Not Epub
Abstract:
For over 15 years, antisense morpholino oligonucleotides (MOs) have allowed developmental biologists to make key discoveries...
Link:
http://www.sciencedirect.com/science/article/pii/S1534580715006188
Citation Extract:
Blum M, De Robertis EM, Wallingford JB, Niehrs C. Morpholinos: Antisense and Sensibility. Dev Cell. 2015;35(2):145-9. doi:10.1016/j.devcel.2015.09.017.

Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1

Authors:
Dunican DS, Pennings S, Meehan RR
Citation:
Biomed Res Int. 2015;2015:740637. doi: 10.1155/2015/740637. Epub 2015 Sep 28
Epub:
Not Epub
Abstract:
Eukaryotic genomes are methylated at cytosine bases in the context of CpG dinucleotides, a pattern which is maintained through...
Link:
http://www.hindawi.com/journals/bmri/2015/740637/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish & Xenopus laevis
Citation Extract:
Dunican DS, Pennings S, Meehan RR. Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1. Biomed Res Int. 2015;2015:740637. doi: 10.1155/2015/740637. Epub 2015 Sep 28.

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization

Authors:
Bizet AA, Becker-Heck A, Ryan R, Weber K, Filhol E, Krug P, Halbritter J, Delous M, Lasbennes MC, Linghu B, Oakeley EJ, Zarhrate M, Nitschké P, Garfa-Traore M, Serluca F, Yang F, Bouwmeester T, Pinson L, Cassuto E, Dubot P, Elshakhs NA, Sahel JA, Salomon R, Drummond IA, Gubler MC, Antignac C, Chibout S, Szustakowski JD, Hildebrandt F, Lorentzen E, Sailer AW, Benmerah A, Saint-Mezard P, Saunier S
Citation:
Nat Commun. 2015 Oct 21;6:8666. doi: 10.1038/ncomms9666
Epub:
Not Epub
Abstract:
Ciliopathies are a large group of clinically and genetically heterogeneous disorders caused by defects in primary cilia. Here...
Link:
http://www.nature.com/ncomms/2015/151021/ncomms9666/full/ncomms9666.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bizet AA, Becker-Heck A, Ryan R, Weber K, Filhol E, Krug P, Halbritter J, Delous M, Lasbennes MC, Linghu B, Oakeley EJ, Zarhrate M, Nitschké P, Garfa-Traore M, Serluca F, Yang F, Bouwmeester T, Pinson L, Cassuto E, Dubot P, Elshakhs NA, Sahel JA, Salomon R, Drummond IA, Gubler MC, Antignac C, Chibout S, Szustakowski JD, Hildebrandt F, Lorentzen E, Sailer AW, Benmerah A, Saint-Mezard P, Saunier S. Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nat Commun. 2015 Oct 21;6:8666. doi: 10.1038/ncomms9666.

NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish

Authors:
Dona M, Bachmann-Gagescu R, Texier Y, Toedt G, Hetterschijt L, Tonnaer EL, Peters TA, van Beersum SE, Bergboer JG, Horn N, de Vrieze E, Slijkerman RW, van Reeuwijk J, Flik G, Keunen JE, Ueffing M, Gibson TJ, Roepman R, Boldt K, Kremer H, van Wijk E
Citation:
PLoS Genet. 2015 Oct 20;11(10):e1005574. doi: 10.1371/journal.pgen.1005574. eCollection 2015 Oct
Epub:
Not Epub
Abstract:
Ciliopathies are Mendelian disorders caused by dysfunction of cilia, ubiquitous organelles involved in fluid propulsion (motile...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005574
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dona M, Bachmann-Gagescu R, Texier Y, Toedt G, Hetterschijt L, Tonnaer EL, Peters TA, van Beersum SE, Bergboer JG, Horn N, de Vrieze E, Slijkerman RW, van Reeuwijk J, Flik G, Keunen JE, Ueffing M, Gibson TJ, Roepman R, Boldt K, Kremer H, van Wijk E. NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish. PLoS Genet. 2015 Oct 20;11(10):e1005574. doi: 10.1371/journal.pgen.1005574. eCollection 2015 Oct.

ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos

Authors:
Shipp LE, Hill RZ, Moy GW, Gökırmak T, Hamdoun A
Citation:
Development. 2015 Oct 15;142(20):3537-48. doi: 10.1242/dev.126144. Epub 2015 Sep 22
Epub:
Not Epub
Abstract:
ATP-binding cassette (ABC) transporters are evolutionarily conserved proteins that pump diverse substrates across membranes....
Link:
http://dev.biologists.org/content/142/20/3537
Delivery Method:
microinjection
Organism or Cell Type:
sea urchin
Citation Extract:
Shipp LE, Hill RZ, Moy GW, Gökırmak T, Hamdoun A. ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos. Development. 2015 Oct 15;142(20):3537-48. doi: 10.1242/dev.126144. Epub 2015 Sep 22.

Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte

Authors:
Han L, Ge J, Zhang L, Ma R, Hou X, Li B, Moley K, Wang Q
Citation:
Sci Rep. 2015 Oct 20;5:15366. doi: 10.1038/srep15366
Epub:
Not Epub
Abstract:
Sirt6, a member of the sirtuin family of NAD-dependent protein deacetylases, has been implicated in multiple biological...
Link:
http://www.nature.com/articles/srep15366
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Han L, Ge J, Zhang L, Ma R, Hou X, Li B, Moley K, Wang Q. Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte. Sci Rep. 2015 Oct 20;5:15366. doi: 10.1038/srep15366.

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

Authors:
Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen C-H, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP
Citation:
Cell Rep. 2015;[Epub ahead of print] doi:/10.1016/j.celrep.2015.09.026
Epub:
Yes
Abstract:
Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but...
Link:
http://www.cell.com/cell-reports/abstract/S2211-1247%2815%2901037-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen C-H, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP. Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons. Cell Rep. 2015;[Epub ahead of print] doi:/10.1016/j.celrep.2015.09.026.

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