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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules

Authors:
Mallarino LE, Engel C, Ilık İA, Maticzka D, Heyl F, Müller B, Toma A. Yakulov TA, Dengjel J, Backofen R, Akhtar A, Gerd Walz G
Citation:
Sci Rep. 2020;10:15954 doi:10.1038/s41598-020-72905-8
Epub:
Not Epub
Abstract:
Mutations of cilia-associated molecules cause multiple developmental defects that are collectively termed ciliopathies. However...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mallarino LE, Engel C, Ilık İA, Maticzka D, Heyl F, Müller B, Toma A. Yakulov TA, Dengjel J, Backofen R, Akhtar A, Gerd Walz G. Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules. Sci Rep. 2020;10:15954 doi:10.1038/s41598-020-72905-8.

LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function

Authors:
Oh C-K, Park JJ, Ha M, Heo HJ, Kang J, Kwon EJ, Kang JW, Kim Y, Kang JM, Yoon SZ, KO Y, Ko DS, Kim YH
Citation:
Anticancer Res. 2020;40(10):5601-9. doi:10.21873/anticanres.14573
Epub:
Not Epub
Abstract:
Background/Aim: Since pathways involving LRRC17 are related to the survival of patients with various cancers, we analyzed...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oh C-K, Park JJ, Ha M, Heo HJ, Kang J, Kwon EJ, Kang JW, Kim Y, Kang JM, Yoon SZ, KO Y, Ko DS, Kim YH. LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function. Anticancer Res. 2020;40(10):5601-9. doi:10.21873/anticanres.14573.

ndufa7 plays a critical role in cardiac hypertrophy

Authors:
Shi X, Zhang Y, Chen R, Gong Y, Zhang M, Guan R, Rotstein OD, Liu X, Wen X-Y
Citation:
J Cell Molec Med. 2020;[Epub ahead of print] doi:10.1111/jcmm.15921
Epub:
Yes
Abstract:
Cardiac hypertrophy is a common pathological change in patients with progressive cardiac function failure, which can be caused...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shi X, Zhang Y, Chen R, Gong Y, Zhang M, Guan R, Rotstein OD, Liu X, Wen X-Y. ndufa7 plays a critical role in cardiac hypertrophy. J Cell Molec Med. 2020;[Epub ahead of print] doi:10.1111/jcmm.15921.

Multilineage murine stem cells generate complex organoids to model distal lung development and disease

Authors:
Vazquez‐Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Hessler MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadász I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S
Citation:
EMBO J. 2020;e103476 [Epub] doi:10.15252/embj.2019103476
Epub:
Not Epub
Abstract:
Organoids derived from mouse and human stem cells have recently emerged as a powerful tool to study organ development and...
Delivery Method:
cell bathing
Organism or Cell Type:
cell culture: murine bronchioalveolar lung organoid (BALO)
Citation Extract:
Vazquez‐Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Hessler MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadász I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S. Multilineage murine stem cells generate complex organoids to model distal lung development and disease. EMBO J. 2020;e103476 [Epub] doi:10.15252/embj.2019103476.

Internal Oligoguanidinium Transporter: Mercury Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitisation of Taxol

Authors:
Kundu J, Banerjee P, Bose C, Das U, Ghosh U, Sinha S
Citation:
Bioconjug Chem. 2020:[Epub ahead of print] doi:10.1021/acs.bioconjchem.0c00444
Epub:
Yes
Abstract:
A non toxic delivery vehicle is essential for the therapeutic applications of antisense phosphorodiamidate morpholino...
Delivery Method:
internal oligoguanidinium transporter (IGT)
Organism or Cell Type:
cell culture: MCF-7
Citation Extract:
Kundu J, Banerjee P, Bose C, Das U, Ghosh U, Sinha S. Internal Oligoguanidinium Transporter: Mercury Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitisation of Taxol. Bioconjug Chem. 2020:[Epub ahead of print] doi:10.1021/acs.bioconjchem.0c00444.

Slit2 is essential for correct retinal ganglion cell axon fasciculation and midline crossing in the zebrafish

Authors:
Davison C, Zolessi FR
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.25.314062
Epub:
Not Epub
Abstract:
The functional connection of the retina with the brain implies the extension of retinal ganglion cells axons through a long and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Davison C, Zolessi FR. Slit2 is essential for correct retinal ganglion cell axon fasciculation and midline crossing in the zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.25.314062 .

Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics

Authors:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ
Citation:
PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467
Epub:
Not Epub
Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467.

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Authors:
Weger M, Weger BD, Schink A, Takamiya M, Stegmaier J, Gobet C, Parisi A, Kobitski AY, Mertes J, Krone N, Strähle U, Nienhaus GU, Mikut R, Gachon F, Gut P, Dickmeis T
Citation:
eLife. 2020;9:e57088 doi:10.7554/eLife.57068
Epub:
Not Epub
Abstract:
The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Weger M, Weger BD, Schink A, Takamiya M, Stegmaier J, Gobet C, Parisi A, Kobitski AY, Mertes J, Krone N, Strähle U, Nienhaus GU, Mikut R, Gachon F, Gut P, Dickmeis T. MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLife. 2020;9:e57088 doi:10.7554/eLife.57068.

The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity

Authors:
Demy DL, Carrère M, Noche R, Tauzin M, Le Bris M, Baek C, Leshchiner I, Goessling W, Herbomel P
Citation:
J Cell Sci. 2020;[Epub ahead of print] doi: 10.1242/jcs.249037
Epub:
Not Epub
Abstract:
Most tissues harbor a substantial population of resident macrophages. Here we elucidate a functional link between the Slc7a7...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Demy DL, Carrère M, Noche R, Tauzin M, Le Bris M, Baek C, Leshchiner I, Goessling W, Herbomel P. The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity. J Cell Sci. 2020;[Epub ahead of print] doi: 10.1242/jcs.249037.

Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid Capitella teleta

Authors:
Lanza AR, Seaver EC
Citation:
Development. 2020 Sep 23;147(18):dev189373. doi: 10.1242/dev.189373
Epub:
Not Epub
Abstract:
The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by...
Delivery Method:
microinjection
Organism or Cell Type:
Capitella teleta (annelid)
Citation Extract:
Lanza AR, Seaver EC. Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid Capitella teleta. Development. 2020 Sep 23;147(18):dev189373. doi: 10.1242/dev.189373.

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