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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro

Authors:
Ma Y-y, Li J-r, Peng Z-g, Zhang J-p
Citation:
Dell Death Dis. 2020;11:200. doi:10.1038/s41419-020-2400-9
Epub:
Not Epub
Abstract:
Interferon lambda-2 (IL28A) has a wide antiviral effect with fewer side-effects. Autophagy is a host mechanism to maintain...
Link:
https://www.nature.com/articles/s41419-020-2400-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma Y-y, Li J-r, Peng Z-g, Zhang J-p. IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro. Dell Death Dis. 2020;11:200. doi:10.1038/s41419-020-2400-9.

Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca2+ Imaging

Authors:
Cozzolino O, Sicca F, Paoli E, Trovato F, Santorelli MF, Ratto MG, Marchese M
Citation:
Cells. 2020;9(3):769. doi:10.3390/cells9030769
Epub:
Not Epub
Abstract:
The study of sources and spatiotemporal evolution of ictal bursts is critical for the mechanistic understanding of epilepsy and...
Link:
https://www.mdpi.com/2073-4409/9/3/769
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cozzolino O, Sicca F, Paoli E, Trovato F, Santorelli MF, Ratto MG, Marchese M. Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca2+ Imaging. Cells. 2020;9(3):769. doi:10.3390/cells9030769.

ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies

Authors:
Xia H, Zhang Q, Shen Y, Bai Y, Ma X, Zhang B, Qi Y, Zhang J, Hu Q, Du W, Zhu L, Zhou P, Wang B, Xu H, Huang L, Li X
Citation:
Mol Ther Nucleic Acids. 2020 Jun 5;20:217-230. doi: 10.1016/j.omtn.2020.02.010. Epub 2020 Feb 28. PMID: 32200270; PMCID: PMC7090285
Epub:
Not Epub
Abstract:
Neovascular age-related macular degeneration (AMD) is characterized by the formation of choroidal neovascularization, which is...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30087-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xia H, Zhang Q, Shen Y, Bai Y, Ma X, Zhang B, Qi Y, Zhang J, Hu Q, Du W, Zhu L, Zhou P, Wang B, Xu H, Huang L, Li X. ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies. Mol Ther Nucleic Acids. 2020 Jun 5;20:217-230. doi: 10.1016/j.omtn.2020.02.010. Epub 2020 Feb 28. PMID: 32200270; PMCID: PMC7090285.

Exploration and Evaluation of Therapeutic Efficacy of Drug-Free Macromolecular Therapeutics in Collagen-Induced Rheumatoid Arthritis Mouse Model

Authors:
Wang J, Li Y, Li L, Yang J, Kopeček J
Citation:
Macromol Biosci. 2020 Mar 20:e1900445. doi: 10.1002/mabi.201900445. [Epub ahead of print]
Epub:
Yes
Abstract:
Monoclonal antibodies (mAbs) against B cell antigens are extensively used in the treatment of rheumatoid arthritis (RA). The B...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.201900445
Organism or Cell Type:
mice
Citation Extract:
Wang J, Li Y, Li L, Yang J, Kopeček J. Exploration and Evaluation of Therapeutic Efficacy of Drug-Free Macromolecular Therapeutics in Collagen-Induced Rheumatoid Arthritis Mouse Model. Macromol Biosci. 2020 Mar 20:e1900445. doi: 10.1002/mabi.201900445. [Epub ahead of print].

Critical role for cold shock protein YB-1 in cytokinesis

Authors:
Mehta S, Algie M, Al-Jabri T, McKinney C, Kannan S, Verma CS, Ma W, Zhang J, Bartolec TK, Masamsetti VP, Parker K, Henderson L, Gould M, Bhatia P, Harfoot R, Chircop M, Kleffmann T, Cohen S, Woolley A, Cesare AJ, Braithwaite A
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.03.18.997817
Epub:
Not Epub
Abstract:
High levels of the cold shock protein Y-box-binding protein-1, YB-1, are tightly correlated with increased cell proliferation...
Link:
https://www.biorxiv.org/content/10.1101/2020.03.18.997817v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mehta S, Algie M, Al-Jabri T, McKinney C, Kannan S, Verma CS, Ma W, Zhang J, Bartolec TK, Masamsetti VP, Parker K, Henderson L, Gould M, Bhatia P, Harfoot R, Chircop M, Kleffmann T, Cohen S, Woolley A, Cesare AJ, Braithwaite A. Critical role for cold shock protein YB-1 in cytokinesis. bioRxiv. 2020;[preprint] doi:10.1101/2020.03.18.997817.

PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury

Authors:
William R, Guixin Z, Isabelle S, Jianli H, Li-qing J, Li Shuxin L, Selzer ME
Citation:
Front Cell Neurosci. 2020;14:61. doi:10.3389/fncel.2020.00061
Epub:
Not Epub
Abstract:
Traumatic spinal cord injury (SCI) results in persistent functional deficits due to the lack of axon regeneration within the...
Link:
https://www.frontiersin.org/articles/10.3389/fncel.2020.00061/full
Delivery Method:
applied at lesion
Organism or Cell Type:
Petromyzon marinus (sea lamprey)
Citation Extract:
William R, Guixin Z, Isabelle S, Jianli H, Li-qing J, Li Shuxin L, Selzer ME. PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury. Front Cell Neurosci. 2020;14:61. doi:10.3389/fncel.2020.00061.

Correction of Bcl‐x splicing improves responses to imatinib in chronic myeloid leukaemia cells and mouse models

Authors:
Zhang J, Wang Y, Li S-Q, Fang L, Wang X-Z, Li J, Zhang H-B, Huang B, Xu Y-M, Yang W-M, Lin J, Min Q-H, ZLiao Z-H, Wu Y, Liu J
Citation:
Brit J Hematol. 2020;[Epub] doi:10.1111/bjh.16472
Epub:
Yes
Abstract:
Imatinib mesylate (IM) resistance has become a major clinical problem for chronic myeloid leukaemia (CML). It is known that Bcl...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.16472
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: chronic myeloid leukaemia (CML) cells
Citation Extract:
Zhang J, Wang Y, Li S-Q, Fang L, Wang X-Z, Li J, Zhang H-B, Huang B, Xu Y-M, Yang W-M, Lin J, Min Q-H, ZLiao Z-H, Wu Y, Liu J. Correction of Bcl‐x splicing improves responses to imatinib in chronic myeloid leukaemia cells and mouse models. Brit J Hematol. 2020;[Epub] doi:10.1111/bjh.16472.

tRIP‐seq reveals repression of premature polyadenylation by co‐transcriptional FUS‐U1 snRNP assembly

Authors:
Masuda A, Kawachi T, Takeda J-i, Ohkawara B, Ito M, Ohno K
Citation:
EMBO Rep. 2020;[Epub] doi:10.15252/embr.201949890
Epub:
Not Epub
Abstract:
RNA processing occurs co‐transcriptionally through the dynamic recruitment of RNA processing factors to RNA polymerase II (...
Link:
https://www.embopress.org/doi/abs/10.15252/embr.201949890
Citation Extract:
Masuda A, Kawachi T, Takeda J-i, Ohkawara B, Ito M, Ohno K. tRIP‐seq reveals repression of premature polyadenylation by co‐transcriptional FUS‐U1 snRNP assembly. EMBO Rep. 2020;[Epub] doi:10.15252/embr.201949890.

De Novo Frameshift Variants in the Neuronal Splicing Factor NOVA2 Result in a Common C-Terminal Extension and Cause a Severe Form of Neurodevelopmental Disorder

Authors:
Mattioli F, Hayot G, Drouot N, Isidor B, Courraud J, Hinckelmann M-V, Mau-Them FT, Sellier C, Goldman A, Telegrafi A, Boughton A, Gamble C, Moutton S, Quartier A, Jean N, Van Ness P, Grotto S, Nambot S, Douglas G, Si YC, Chelly J, Shad Z, Kaplan E, Dineen R, Golzio C, Charlet-Berguerand N, Mandel J-L, Piton A
Citation:
Am J Hum Genet. 2020;[Epub ahead of print] doi:10.1016/j.ajhg.2020.02.013
Epub:
Yes
Abstract:
The neuro-oncological ventral antigen 2 (NOVA2) protein is a major factor regulating neuron-specific alternative splicing (AS...
Link:
https://www.cell.com/ajhg/pdfExtended/S0002-9297(20)30055-0
Organism or Cell Type:
zebrafish
Citation Extract:
Mattioli F, Hayot G, Drouot N, Isidor B, Courraud J, Hinckelmann M-V, Mau-Them FT, Sellier C, Goldman A, Telegrafi A, Boughton A, Gamble C, Moutton S, Quartier A, Jean N, Van Ness P, Grotto S, Nambot S, Douglas G, Si YC, Chelly J, Shad Z, Kaplan E, Dineen R, Golzio C, Charlet-Berguerand N, Mandel J-L, Piton A. De Novo Frameshift Variants in the Neuronal Splicing Factor NOVA2 Result in a Common C-Terminal Extension and Cause a Severe Form of Neurodevelopmental Disorder. Am J Hum Genet. 2020;[Epub ahead of print] doi:10.1016/j.ajhg.2020.02.013.

Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer-PPMO and AAV-U7 rescues the severe DMD phenotype in mice

Authors:
Forand A, Muchir A, Mougenot N, Sevoz-Couche C, Peccate C, Lemaitre M, Izabelle C, Wood MJA, Lorain SL, Piétri-Rouxel F
Citation:
Molec Ther Methods Clin Devel. 2020;17:695-708. doi:10.1016/j.omtm.2020.03.011
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease caused by an absence of the dystrophin protein, which...
Link:
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(20)30041-3
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Forand A, Muchir A, Mougenot N, Sevoz-Couche C, Peccate C, Lemaitre M, Izabelle C, Wood MJA, Lorain SL, Piétri-Rouxel F. Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer-PPMO and AAV-U7 rescues the severe DMD phenotype in mice. Molec Ther Methods Clin Devel. 2020;17:695-708. doi:10.1016/j.omtm.2020.03.011.

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