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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice
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Citation:
Mol Cell Biol. 2014 Aug 1;34(15):2874-89. doi: 10.1128/MCB.00135-14. Epub 2014 May 27 Epub:
Not Epub Abstract:
Noonan syndrome (NS) is an autosomal dominant disorder caused by activating mutations in the PTPN11 gene encoding Shp2, which... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Paardekooper Overman J, Yi JS, Bonetti M, Soulsby M, Preisinger C, Stokes MP, Hui L, Silva JC, Overvoorde J, Giansanti P, Heck AJ, Kontaridis MI, den Hertog J, Bennett AM. PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice. Mol Cell Biol. 2014 Aug 1;34(15):2874-89. doi: 10.1128/MCB.00135-14. Epub 2014 May 27. |
EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia
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Citation:
Nat Commun. 2014 Jul 3;5:4287. doi: 10.1038/ncomms5287 Epub:
Not Epub Abstract:
The exosome is a multi-protein complex, required for the degradation of AU-rich element (ARE) containing messenger RNAs (mRNAs... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Boczonadi V, Müller JS, Pyle A, Munkley J, Dor T, Quartararo J, Ferrero I, Karcagi V, Giunta M, Polvikoski T, Birchall D, Princzinger A, Cinnamon Y, Lützkendorf S, Piko H, Reza M, Florez L, Santibanez-Koref M, Griffin H, Schuelke M, Elpeleg O, Kalaydjieva L, Lochmüller H, Elliott DJ, Chinnery PF, Edvardson S, Horvath R. EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Nat Commun. 2014 Jul 3;5:4287. doi: 10.1038/ncomms5287. |
Targeted Resequencing and Systematic In Vivo Functional Testing Identifies Rare Variants in MEIS1 as Significant Contributors to Restless Legs Syndrome
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Citation:
Am J Hum Genet. 2014 Jul 3;95(1):85-95. doi:10.1016/j.ajhg.2014.06.005 Epub:
Not Epub Abstract:
Restless legs syndrome (RLS) is a common neurologic condition characterized by nocturnal dysesthesias and an urge to move,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Schulte EC, Kousi M, Tan PL, Tilch E, Knauf F, Lichtner P, Trenkwalder C, Högl B, Frauscher B, Berger K, Fietze I, Hornyak M, Oertel WH, Bachmann CG, Zimprich A, Peters A, Gieger C, Meitinger T, Müller-Myhsok B, Katsanis N, Winkelmann J. Targeted Resequencing and Systematic In Vivo Functional Testing Identifies Rare Variants in MEIS1 as Significant Contributors to Restless Legs Syndrome. Am J Hum Genet. 2014 Jul 3;95(1):85-95. doi:10.1016/j.ajhg.2014.06.005. |
In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity
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Citation:
J Cell Biol. 2014;206:113-127. doi:10.1083/jcb.201402093 Epub:
Not Epub Abstract:
Collective cell migration (CCM) and epithelial-mesenchymal transition (EMT) are common to cancer and morphogenesis, and are... Delivery Method:
microinjection Organism or Cell Type:
cell culture & in vivo: Xenopus Citation Extract: Kuriyama S, Theveneau E, Benedetto A, Parsons M, Tanaka M, Charras G, Kabla A, Mayor R. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. J Cell Biol. 2014;206:113-127. doi:10.1083/jcb.201402093 . |
Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development
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Citation:
Cell. 2014;[Epub ahead of print] doi:10.1016/j.cell.2014.06.017 Epub:
Not Epub Abstract:
Autism spectrum disorder (ASD) is a heterogeneous disease in which efforts to define subtypes behaviorally have met with... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bernier R, Golzio C, Xiong B, Stessman HA, Coe BP, Penn O, Witherspoon K, Gerdts J, Baker C, Vulto-van Silfhout AT, Schuurs-Hoeijmakers JH, Fichera M, Bosco P, Buono S, Alberti A, Failla P, Peeters H, Steyaert J, Vissers LELM, Francescatto L, Mefford HC, Rosenfeld JA, Bakken T, O’Roak BJ, Pawlus M, Moon R, Shendure J, Amaral DG, Lein E, Rankin J, Romano C, de Vries BBA, Katsanis N, Eichler EE.. Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development. Cell. 2014;[Epub ahead of print] doi:10.1016/j.cell.2014.06.017. |
The zebrafish Tie2 signaling controls tip cell behaviors and acts synergistically with Vegf pathway in developmental angiogenesis
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Citation:
Acta Biochim Biophys Sin. 2014;[Epub ahead of print] doi:10.1093/abbs/gmu055 Epub:
Yes Abstract:
Angiogenesis process in development is temporally accurate, and involves sprouting, subsequent endothelial cell proliferation,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li W, Chen J, Deng M, Jing Q. The zebrafish Tie2 signaling controls tip cell behaviors and acts synergistically with Vegf pathway in developmental angiogenesis. Acta Biochim Biophys Sin. 2014;[Epub ahead of print] doi:10.1093/abbs/gmu055 . |
FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation
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Citation:
Oncotarget. 2014;5 Epub:
Not Epub Abstract:
Chordoma is a rare malignant tumor that recapitulates the notochord phenotype and is thought to derive from notochord remnants... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ferrari L, Pistocchi A, Libera L, Boari N, Mortini P, Bellipanni G, Giordano A, Cotelli F, Riva P. FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Oncotarget. 2014;5. |
Phosphorodiamidate Morpholino Oligomers (PMOs) suppress mutant huntingtin expression and attenuate neurotoxicity
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Citation:
Hum Mol Genet. 2014;[Epub ahead of print] doi:10.1093/hmg/ddu349 Epub:
Yes Abstract:
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin... Organism or Cell Type:
mice, cell culture: patient fibroblasts Citation Extract: Sun X, Marque LO, Cordner Z, Pruitt JL, Bhat M, Li P, Kannan G, Ladenheim EE, Moran TH, Margolis RL, Rudnicki DD. Phosphorodiamidate Morpholino Oligomers (PMOs) suppress mutant huntingtin expression and attenuate neurotoxicity. Hum Mol Genet. 2014;[Epub ahead of print] doi:10.1093/hmg/ddu349 . |
Reversing paclitaxel resistance in ovarian cancer cells via inhibition of the ABCB1 expressing side population
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Citation:
Tumour Biol. 2014 Jul 4. [Epub ahead of print] Epub:
Yes Abstract:
The majority of deaths in ovarian cancer are caused by recurrent metastatic disease which is usually multidrug resistant. This... Organism or Cell Type:
cell culture: ovarian cancer cell line Citation Extract: Eyre R, Harvey I, Stemke-Hale K, Lennard TW, Tyson-Capper A, Meeson AP. Reversing paclitaxel resistance in ovarian cancer cells via inhibition of the ABCB1 expressing side population. Tumour Biol. 2014 Jul 4. [Epub ahead of print]. |
Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos
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Citation:
Circ Res. 2014 Jan 3;114(1):56-66. doi: 10.1161/CIRCRESAHA.114.302452. Epub 2013 Oct 11 Epub:
Not Epub Abstract:
RATIONALE: The emergence of lymphatic endothelial cells (LECs) seems to be highly regulated during development. Although... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW. Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos. Circ Res. 2014 Jan 3;114(1):56-66. doi: 10.1161/CIRCRESAHA.114.302452. Epub 2013 Oct 11. |