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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

Authors:
Gao X, Ran N, Dong X, Zuo B, Yang R, Zhuo Q, Hong M. Moulton HM, Seow Y, Yin HF
Citation:
Sci Transl Med. 2018;10(444):eaat0195. doi:10.1126/scitranslmed.aat0195
Epub:
Not Epub
Abstract:
Exosomes are circulating nanovesicular carriers of macromolecules, increasingly used for diagnostics and therapeutics. The...
Delivery Method:
exosome
Organism or Cell Type:
mice
Citation Extract:
Gao X, Ran N, Dong X, Zuo B, Yang R, Zhuo Q, Hong M. Moulton HM, Seow Y, Yin HF. Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy. Sci Transl Med. 2018;10(444):eaat0195. doi:10.1126/scitranslmed.aat0195.

Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

Authors:
Malhotra D, Shin J, Solnica-Krezel L, Raz E
Citation:
eLife. 2018;7:e33574. doi:10.7554/eLife.33574
Epub:
Not Epub
Abstract:
Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Malhotra D, Shin J, Solnica-Krezel L, Raz E. Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors. eLife. 2018;7:e33574. doi:10.7554/eLife.33574.

Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish

Authors:
Kinoshita H, Ohgane N, Fujino Y, Yabe T, Hiroki Ovara H, Yokota D, Izuka A, Kage D, Yamasu K, Takada S, Kawamura A
Citation:
Mech Dev. 2018;[Epub ahead of print] doi:10.1016/j.mod.2018.06.001
Epub:
Yes
Abstract:
Somites sequentially form with a regular interval by the segmentation from the anterior region of the presomitic mesoderm (PSM...
Organism or Cell Type:
zebrafish
Citation Extract:
Kinoshita H, Ohgane N, Fujino Y, Yabe T, Hiroki Ovara H, Yokota D, Izuka A, Kage D, Yamasu K, Takada S, Kawamura A. Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish. Mech Dev. 2018;[Epub ahead of print] doi:10.1016/j.mod.2018.06.001.

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

Authors:
Kendall GC, Watson S, Xu L, LaVigne CA, Murchison W, Rakheja D, Skapek SX, Tirode F, Delattre O, Amatruda JF
Citation:
eLife. 2018;7:e33800 doi: 10.7554/eLife.33800
Epub:
Not Epub
Abstract:
Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused by PAX3/7-FOXO1 fusion oncogenes and is characterized by...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kendall GC, Watson S, Xu L, LaVigne CA, Murchison W, Rakheja D, Skapek SX, Tirode F, Delattre O, Amatruda JF. PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis. eLife. 2018;7:e33800 doi: 10.7554/eLife.33800.

The homeobox protein VentX reverts immune suppression in the tumor microenvironment

Authors:
Le Y, Gao H, Bleday R, Zhu Z
Citation:
Nat Comm. 2018;9:2175. doi:10.1038/s41467-018-04567-0
Epub:
Not Epub
Abstract:
Immune suppression in the tumor microenvironment (TME) is a central obstacle to effective immunotherapy. Tumor-associated...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: human tumor associated macrophages (TAM) or human primary monocytes
Citation Extract:
Le Y, Gao H, Bleday R, Zhu Z. The homeobox protein VentX reverts immune suppression in the tumor microenvironment. Nat Comm. 2018;9:2175. doi:10.1038/s41467-018-04567-0.

The macrophage as a Trojan horse for antisense oligonucleotide delivery

Authors:
Novak JS, Jaiswal JK, Partridge TA
Citation:
Expert Opin Ther Targets. 2018 Jun 4. doi: 10.1080/14728222.2018.1482279. [Epub ahead of print]
Epub:
Yes
Abstract:
The gateway to the promised land of gene therapy has been obstructed by the problem of accurate and efficient delivery of...
Citation Extract:
Novak JS, Jaiswal JK, Partridge TA. The macrophage as a Trojan horse for antisense oligonucleotide delivery. Expert Opin Ther Targets. 2018 Jun 4. doi: 10.1080/14728222.2018.1482279. [Epub ahead of print].

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

Authors:
Merks AM, Swinarski M, Meyer AM, Müller NV, Özcan I, Donat S, Burger A, Gilbert S, Mosimann C, Abdelilah-Seyfried S, Panáková D
Citation:
Nat Comm. 2018;9:2161. doi:10.1038/s41467-018-04566-1
Epub:
Not Epub
Abstract:
Development of a multiple-chambered heart from the linear heart tube is inherently linked to cardiac looping. Although many...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Merks AM, Swinarski M, Meyer AM, Müller NV, Özcan I, Donat S, Burger A, Gilbert S, Mosimann C, Abdelilah-Seyfried S, Panáková D. Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nat Comm. 2018;9:2161. doi:10.1038/s41467-018-04566-1.

TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons

Authors:
Kelu JJ, Webb SE, Galione A, Miller AL
Citation:
Dev Biol. 2018 Jun 1;438(1):57-68. doi: 10.1016/j.ydbio.2018.02.011. Epub 2018 Mar 23
Epub:
Not Epub
Abstract:
During the development of the early spinal circuitry in zebrafish, spontaneous Ca2+ transients in the primary motor neurons (...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kelu JJ, Webb SE, Galione A, Miller AL. TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons. Dev Biol. 2018 Jun 1;438(1):57-68. doi: 10.1016/j.ydbio.2018.02.011. Epub 2018 Mar 23.

The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish

Authors:
Lai JKH, Collins MM, Uribe V, Jiménez-Amilburu V, Günther S, Maischein HM, Stainier DYR
Citation:
Development. 2018 May 17;145(10). pii: dev159210. doi: 10.1242/dev.159210
Epub:
Not Epub
Abstract:
Cardiac trabeculation is a highly regulated process that starts with the delamination of compact layer cardiomyocytes. The...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lai JKH, Collins MM, Uribe V, Jiménez-Amilburu V, Günther S, Maischein HM, Stainier DYR. The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish. Development. 2018 May 17;145(10). pii: dev159210. doi: 10.1242/dev.159210.

Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish

Authors:
Yang Q, Yan C, Gong Z
Citation:
Sci Rep. 2018;8:8495 doi:10.1038/s41598-018-26612-0
Epub:
Not Epub
Abstract:
Activation of hepatic stellate cells (HSC) plays a crucial role in the liver disease progression from liver fibrosis/cirrhosis...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang Q, Yan C, Gong Z. Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish. Sci Rep. 2018;8:8495 doi:10.1038/s41598-018-26612-0.

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