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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Jmjd6a regulates GSK3β RNA splicing in Xenopus laevis eye development

Authors:
Shin JY, Son J, Kim WS, Gwak J, Ju BG
Citation:
PLoS One. 2019 Jul 30;14(7):e0219800. doi: 10.1371/journal.pone.0219800. eCollection 2019
Epub:
Not Epub
Abstract:
It has been suggested that Jmjd6 plays an important role in gene regulation through its demethylation or hydroxylation activity...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Shin JY, Son J, Kim WS, Gwak J, Ju BG. Jmjd6a regulates GSK3β RNA splicing in Xenopus laevis eye development. PLoS One. 2019 Jul 30;14(7):e0219800. doi: 10.1371/journal.pone.0219800. eCollection 2019.

Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts

Authors:
Molinari E, Ramsbottom SA, Srivastava S, Booth P, Alkanderi S, McLafferty SM, Devlin LA, White K, Gunay-Aygun M, Miles CG, Sayer JA
Citation:
Sci Rep. 2019 Jul 25;9(1):10828. doi: 10.1038/s41598-019-47243-z
Epub:
Not Epub
Abstract:
Joubert syndrome (JBTS) is an incurable multisystem ciliopathy syndrome. The most commonly mutated gene in JBTS patients with a...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: primary human fibroblasts
Citation Extract:
Molinari E, Ramsbottom SA, Srivastava S, Booth P, Alkanderi S, McLafferty SM, Devlin LA, White K, Gunay-Aygun M, Miles CG, Sayer JA. Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts. Sci Rep. 2019 Jul 25;9(1):10828. doi: 10.1038/s41598-019-47243-z.

Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior

Authors:
Namba MD, Kupchik YM, Spencer SM, Garcia-Keller C, Goenaga JG, Powell GL, Vicino IA, Hogue IB, Gipson CD
Citation:
Addict Biol. 2019 Jul 22:e12797. doi: 10.1111/adb.12797. [Epub ahead of print]
Epub:
Yes
Abstract:
Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and the cystine...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
rats
Citation Extract:
Namba MD, Kupchik YM, Spencer SM, Garcia-Keller C, Goenaga JG, Powell GL, Vicino IA, Hogue IB, Gipson CD. Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior. Addict Biol. 2019 Jul 22:e12797. doi: 10.1111/adb.12797. [Epub ahead of print].

Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B

Authors:
Zhai X, Wang L, Xu C, Hou Q, Zhang L, Li Z, Qin W, Liu Z, Chen Z
Citation:
Arch Biochem Biophys. 2019 Jul 19;671:210-217. doi: 10.1016/j.abb.2019.07.012. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Podocytes are important to glomerular filtration barrier integrity and maintenance of size selectivity in protein filtration in...
Organism or Cell Type:
zebrafish
Citation Extract:
Zhai X, Wang L, Xu C, Hou Q, Zhang L, Li Z, Qin W, Liu Z, Chen Z. Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B. Arch Biochem Biophys. 2019 Jul 19;671:210-217. doi: 10.1016/j.abb.2019.07.012. [Epub ahead of print].

Exons 45-55 skipping using mutation-tailored cocktails of antisense morpholinos in the DMD gene

Authors:
Echigoya Y, Lim KRQ, Melo D, Bao B, Trieu N, Mizobe Y, Maruyama R, Mamchaoui K, Tanihata J, Aoki Y, Takeda S, Mouly V, Duddy W, Yokota T
Citation:
Molec Ther. 2019;[Epub ahead of print] doi:10.1016/j.ymthe.2019.07.012
Epub:
Yes
Abstract:
Mutations in the dystrophin (DMD) gene and consequent loss of dystrophin cause Duchenne muscular dystrophy (DMD). A promising...
Organism or Cell Type:
cell culture
Citation Extract:
Echigoya Y, Lim KRQ, Melo D, Bao B, Trieu N, Mizobe Y, Maruyama R, Mamchaoui K, Tanihata J, Aoki Y, Takeda S, Mouly V, Duddy W, Yokota T. Exons 45-55 skipping using mutation-tailored cocktails of antisense morpholinos in the DMD gene. Molec Ther. 2019;[Epub ahead of print] doi:10.1016/j.ymthe.2019.07.012.

The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection

Authors:
Yang D, Liu X, Xu W, Gu Z, Yang C, Zhang L, Tan J, Zheng X, Wang Z, Quan S, Zhang Y, Liu Q
Citation:
PLoS Pathog. 2019;15(7):e1007917. doi:10.1371/journal.ppat.1007917
Epub:
Not Epub
Abstract:
It is important that bacterium can coordinately deliver several effectors into host cells to disturb the cellular progress...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang D, Liu X, Xu W, Gu Z, Yang C, Zhang L, Tan J, Zheng X, Wang Z, Quan S, Zhang Y, Liu Q. The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. PLoS Pathog. 2019;15(7):e1007917. doi:10.1371/journal.ppat.1007917.

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Authors:
Halder S, Torrecilla I, Burkhalter MD, Popović M, Fielden J, Vaz B, Oehler J, Pilger D, Lessel D, Wiseman K, Singh AN, Vendrell I, Fischer R, Philipp M, Ramadan K
Citation:
Nat Comm. 2019;10(1):3142. doi:10.1038/s41467-019-11095-y
Epub:
Not Epub
Abstract:
The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Halder S, Torrecilla I, Burkhalter MD, Popović M, Fielden J, Vaz B, Oehler J, Pilger D, Lessel D, Wiseman K, Singh AN, Vendrell I, Fischer R, Philipp M, Ramadan K. SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Nat Comm. 2019;10(1):3142. doi:10.1038/s41467-019-11095-y.

Functions of thioredoxin1 in brain development and in response to environmental chemicals in zebrafish embryos

Authors:
Yang L, Zeng C, Zhang Y, Wang F, Takamiya M, Strähle U
Citation:
Toxicol Lett. 2019:[Epub ahead of print] doi:10.1016/j.toxlet.2019.07.009
Epub:
Yes
Abstract:
Thioredoxin is an evolutionarily conserved antioxidant protein that plays a crucial role for fundamental cellular processes and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang L, Zeng C, Zhang Y, Wang F, Takamiya M, Strähle U. Functions of thioredoxin1 in brain development and in response to environmental chemicals in zebrafish embryos. Toxicol Lett. 2019:[Epub ahead of print] doi:10.1016/j.toxlet.2019.07.009.

The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish

Authors:
De La Garza A, Cameron RC, Gupta V, Fraint E, Nik S, Bowman TV
Citation:
Blood Adv. 2019 Jul 23;3(14):2093-2104. doi: 10.1182/bloodadvances.2018027714
Epub:
Not Epub
Abstract:
The spliceosomal component Splicing Factor 3B, subunit 1 (SF3B1) is one of the most prevalently mutated factors in the bone...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
De La Garza A, Cameron RC, Gupta V, Fraint E, Nik S, Bowman TV. The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish. Blood Adv. 2019 Jul 23;3(14):2093-2104. doi: 10.1182/bloodadvances.2018027714.

Topologically correct central projections of tetrapod inner ear afferents require Fzd3

Authors:
Duncan JS, Fritzsch B, Houston DW, Ketchum EM, Kersigo J, Deans MR, Elliott KL
Citation:
Sci Rep. 2019;9(1):10298. doi:10.1038/s41598-019-46553-6
Epub:
Not Epub
Abstract:
Inner ear sensory afferent connections establish sensory maps between the inner ear hair cells and the vestibular and auditory...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Duncan JS, Fritzsch B, Houston DW, Ketchum EM, Kersigo J, Deans MR, Elliott KL. Topologically correct central projections of tetrapod inner ear afferents require Fzd3. Sci Rep. 2019;9(1):10298. doi:10.1038/s41598-019-46553-6.

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