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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Tracking periocular mesenchyme derived anterior segment development using single cell transcriptomic analysis

Authors:
Voecking O, Smith J, Famulski J
Citation:
Invest Ophthalmol Vis Sci. 2020;61:3175
Epub:
Not Epub
Abstract:
Purpose: The anterior segment (AS) of the eye, as well as further anterior structures, are formed by a subgroup of neural crest...
Link:
https://iovs.arvojournals.org/article.aspx?articleid=2767926
Organism or Cell Type:
zebrafish
Citation Extract:
Voecking O, Smith J, Famulski J. Tracking periocular mesenchyme derived anterior segment development using single cell transcriptomic analysis. Invest Ophthalmol Vis Sci. 2020;61:3175.

Optimizing oligotherapeutics for visual loss in Usher syndrome mice

Authors:
Lentz JJ, Hathaway M, Robillard KN, Ponnath A, Fisher M, Rigo F, Alapure BV
Citation:
Invest Ophthalmol Vis Sci. 2020;Vol.61:2445
Epub:
Not Epub
Abstract:
Purpose : Usher syndrome (Usher) is a syndromic form of inherited retinal dystrophy (IRD) characterized by hearing impairment...
Link:
https://iovs.arvojournals.org/article.aspx?articleid=2767542
Delivery Method:
intravitreal injection
Organism or Cell Type:
mice
Citation Extract:
Lentz JJ, Hathaway M, Robillard KN, Ponnath A, Fisher M, Rigo F, Alapure BV. Optimizing oligotherapeutics for visual loss in Usher syndrome mice. Invest Ophthalmol Vis Sci. 2020;Vol.61:2445.

Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract

Authors:
Sidhwani P, Leerberg DM, Boezio GLM, Capasso TL, Yang H, Chi NC, Roman BL, Stainier DYR, Yelon D
Citation:
Development. 2020;147:dev185900 doi:10.1242/dev.185900
Epub:
Not Epub
Abstract:
Physical forces are important participants in the cellular dynamics that shape developing organs. During heart formation, for...
Link:
https://dev.biologists.org/content/147/12/dev185900
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sidhwani P, Leerberg DM, Boezio GLM, Capasso TL, Yang H, Chi NC, Roman BL, Stainier DYR, Yelon D. Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract. Development. 2020;147:dev185900 doi:10.1242/dev.185900 .

Duped by a duplication: Heterozygous duplication in PRPF31 causes Retinitis pigmentosa in elusive gene family

Authors:
Scott H, Larson A, Chao KR, DiTroia SP, Butcher R, Place E, Pierce EA, Bujakowska K
Citation:
Invest Ophthalmol Vis Sci. 2020;61(7):4468
Epub:
Not Epub
Abstract:
Inherited retinal degenerations (IRD) are an important cause of blindness affecting 1/4000 people worldwide. Presently, over...
Link:
https://iovs.arvojournals.org/article.aspx?articleid=2768578
Organism or Cell Type:
zebrafish
Citation Extract:
Scott H, Larson A, Chao KR, DiTroia SP, Butcher R, Place E, Pierce EA, Bujakowska K. Duped by a duplication: Heterozygous duplication in PRPF31 causes Retinitis pigmentosa in elusive gene family. Invest Ophthalmol Vis Sci. 2020;61(7):4468.

Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves

Authors:
Takamiya M, Stegmaier J, Kobitski AY, Schott B, Weger BD, Margariti D, Delgado ARC, Gourain V, Scherr T, Yang L, Sorge S, Otte JC, Hartmann V, van Wezel J, Stotzka R, Reinhard T, Schlunck G, Dickmeis T, Rastegar S, Mikut R, Nienhaus GU, Strähle U
Citation:
PLoS Genet. 2020;16(6):e1008774. doi:10.1371/journal.pgen.1008774
Epub:
Not Epub
Abstract:
Cranial neural crest (NC) contributes to the developing vertebrate eye. By multidimensional, quantitative imaging, we traced...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008774
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Takamiya M, Stegmaier J, Kobitski AY, Schott B, Weger BD, Margariti D, Delgado ARC, Gourain V, Scherr T, Yang L, Sorge S, Otte JC, Hartmann V, van Wezel J, Stotzka R, Reinhard T, Schlunck G, Dickmeis T, Rastegar S, Mikut R, Nienhaus GU, Strähle U. Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genet. 2020;16(6):e1008774. doi:10.1371/journal.pgen.1008774.

Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency

Authors:
Kozyra EJ, Pastor VB, Lefkopoulos S. Sahoo SS, Busch H, Voss RK, Erlacher M, Lebrecht D, Szvetnik EA, Hirabayashi S, Pasaulienė R, Pedace L, Tartaglia M, Klemann C, Metzger P, Boerries M, Catala A, Hasle H, de Haas V, Kállay K, Masetti R, De Moerloose B, Dworzak M, Schmugge M, Smith O, Starý J, Mejstrikova E, Ussowicz M, Morris E, Singh P, Collin M, Derecka M, Gudrun Göhring G, Flotho C, Strahm B, Locatelli F, Niemeyer CM, Trompouki E, Wlodarski MW, European Working Group of MDS in Childhood (EWOG-MDS)
Citation:
Leukemia. 2020;[Epub]. https://doi.org/10.1038/s41375-020-0899-5
Epub:
Yes
Abstract:
Deficiency of the transcription factor GATA2 is a highly penetrant genetic disorder predisposing to myelodysplastic syndromes (...
Link:
https://www.nature.com/articles/s41375-020-0899-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kozyra EJ, Pastor VB, Lefkopoulos S. Sahoo SS, Busch H, Voss RK, Erlacher M, Lebrecht D, Szvetnik EA, Hirabayashi S, Pasaulienė R, Pedace L, Tartaglia M, Klemann C, Metzger P, Boerries M, Catala A, Hasle H, de Haas V, Kállay K, Masetti R, De Moerloose B, Dworzak M, Schmugge M, Smith O, Starý J, Mejstrikova E, Ussowicz M, Morris E, Singh P, Collin M, Derecka M, Gudrun Göhring G, Flotho C, Strahm B, Locatelli F, Niemeyer CM, Trompouki E, Wlodarski MW, European Working Group of MDS in Childhood (EWOG-MDS). Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency. Leukemia. 2020;[Epub]. https://doi.org/10.1038/s41375-020-0899-5.

Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis

Authors:
Balogh E, Chandler JC, Varga M, Tahoun M, Menyhárd DK, Schay G, Goncalves T, Hamar R, Légrádi R, Szekeres A, Gribouval O, Kleta R, Stanescu H, Bockenhauer D, Kerti A, Williams H, Kinsler V, Di W-L, Curtis D, Kolatsi-Joannou M, Hammid H, Szőcs A, Perczel K, Maka E, Toldi G, Sava F, Arrondel C, Kardos M, Fintha A, Hossain A, D’Arco F, Kaliakatsos M, Koeglmeier J, Mifsud W, Moosajee M, Faro A, Jávorszky E, Rudas G, Saied MH, Marzouk S, Kelen K, Götze J, Reusz G, Tulassay T, Dragon F, Mollet G, Motameny S, Thiele H, Dorval G, Nürnberg P, Perczel A, Szabó AJ, Long DA, Tomita K, Antignac C, Waters AM, Tory K
Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2002328117
Epub:
Yes
Abstract:
RNA modifications play a fundamental role in cellular function. Pseudouridylation, the most abundant RNA modification, is...
Link:
https://www.pnas.org/content/early/2020/06/16/2002328117
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Balogh E, Chandler JC, Varga M, Tahoun M, Menyhárd DK, Schay G, Goncalves T, Hamar R, Légrádi R, Szekeres A, Gribouval O, Kleta R, Stanescu H, Bockenhauer D, Kerti A, Williams H, Kinsler V, Di W-L, Curtis D, Kolatsi-Joannou M, Hammid H, Szőcs A, Perczel K, Maka E, Toldi G, Sava F, Arrondel C, Kardos M, Fintha A, Hossain A, D’Arco F, Kaliakatsos M, Koeglmeier J, Mifsud W, Moosajee M, Faro A, Jávorszky E, Rudas G, Saied MH, Marzouk S, Kelen K, Götze J, Reusz G, Tulassay T, Dragon F, Mollet G, Motameny S, Thiele H, Dorval G, Nürnberg P, Perczel A, Szabó AJ, Long DA, Tomita K, Antignac C, Waters AM, Tory K. Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2002328117.

Pre-mRNA Splicing Modulation by Antisense Oligonucleotides

Authors:
Singh NN, Luo D, Singh RN
Citation:
Methods Mol Biol. 2018;1828:415-437. doi:10.1007/978-1-4939-8651-4_26
Epub:
Not Epub
Abstract:
Pre-mRNA splicing, a dynamic process of intron removal and exon joining, is governed by a combinatorial control exerted by...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_26
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: SMA-patient-derived primary fibroblasts GM03813
Citation Extract:
Singh NN, Luo D, Singh RN. Pre-mRNA Splicing Modulation by Antisense Oligonucleotides. Methods Mol Biol. 2018;1828:415-437. doi:10.1007/978-1-4939-8651-4_26.

DNA-based fluorescent probes of NOS2 activity in live brains

Authors:
Veetil AT, Zou J, Henderson KW, Jani MS, Shaik SM, Sisodia SS, Hale ME, Krishnan Y
Citation:
PNAS USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2003034117
Epub:
Yes
Abstract:
When a pathogen is engulfed by an immune cell, it is trapped in a transient organelle called the phagosome. The host cell...
Link:
https://www.pnas.org/content/early/2020/06/15/2003034117
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Veetil AT, Zou J, Henderson KW, Jani MS, Shaik SM, Sisodia SS, Hale ME, Krishnan Y. DNA-based fluorescent probes of NOS2 activity in live brains. PNAS USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2003034117.

ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1

Authors:
Li F, Liang Y, Han X, Guan Y-n, Chen J, Wu P, Zhao X-x, Jing Q
Citation:
Acta Pharmacol Sin. 2020;[Epub] doi:10.1038/s41401-020-0431-5
Epub:
Not Epub
Abstract:
In the past two decades, purinergic signaling has emerged as a key regulator of hematopoiesis in physiological and pathological...
Link:
https://www.nature.com/articles/s41401-020-0431-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li F, Liang Y, Han X, Guan Y-n, Chen J, Wu P, Zhao X-x, Jing Q . ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1. Acta Pharmacol Sin. 2020;[Epub] doi:10.1038/s41401-020-0431-5.

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