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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Internal Oligoguanidinium Transporter: Mercury-Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization, and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitization of Taxo

Authors:
Kundu J, Banerjee P, Bose C, Das U, Ghosh U, Sinha S
Citation:
Bioconjug Chem. 2020 Oct 21;31(10):2367-2382. doi: 10.1021/acs.bioconjchem.0c00444. Epub 2020 Oct 12
Epub:
Not Epub
Abstract:
A nontoxic delivery vehicle is essential for the therapeutic applications of antisense phosphorodiamidate morpholino...
Link:
https://www.sciencedirect.com/org/science/article/abs/pii/S1043180221010272
Delivery Method:
internal guanidinium
Organism or Cell Type:
cell culture
Citation Extract:
Kundu J, Banerjee P, Bose C, Das U, Ghosh U, Sinha S. Internal Oligoguanidinium Transporter: Mercury-Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization, and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitization of Taxo. Bioconjug Chem. 2020 Oct 21;31(10):2367-2382. doi: 10.1021/acs.bioconjchem.0c00444. Epub 2020 Oct 12.

Neuronal identities derived by misexpression of the POU IV sensory determinant in a protovertebrate

Authors:
Chacha PP, Horie R, Kusakabe TG, Sasakura Y, Singh M, Horie T, Levine M
Citation:
Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2118817119. doi: 10.1073/pnas.2118817119
Epub:
Yes
Abstract:
The protovertebrate Ciona intestinalis type A (sometimes called Ciona robusta) contains a series of sensory cell types...
Link:
https://www.pnas.org/content/119/4/e2118817119
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Chacha PP, Horie R, Kusakabe TG, Sasakura Y, Singh M, Horie T, Levine M. Neuronal identities derived by misexpression of the POU IV sensory determinant in a protovertebrate. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2118817119. doi: 10.1073/pnas.2118817119.

Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1

Authors:
Restuadi R, Steyn FJ, Kabashi E, Ngo ST, Cheng FF, Nabais MF, Thompson MJ, Qi T, Wu Y, Henders AK, Wallace L, Bye CR, Turner BJ, Ziser L, Mathers S, McCombe PA, Needham M, Schultz D, Kiernan MC, van Rheenen W, van den Berg LH, Veldink JH, Ophoff R, Gusev A, Zaitlen N, McRae AF, Henderson RD, Wray NR, Giacomotto J, Garton FC
Citation:
Genome Med. 2022 Jan 19;14(1):7. doi: 10.1186/s13073-021-01006-6
Epub:
Not Epub
Abstract:
Background: Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with a genetic contribution...
Link:
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-021-01006-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Restuadi R, Steyn FJ, Kabashi E, Ngo ST, Cheng FF, Nabais MF, Thompson MJ, Qi T, Wu Y, Henders AK, Wallace L, Bye CR, Turner BJ, Ziser L, Mathers S, McCombe PA, Needham M, Schultz D, Kiernan MC, van Rheenen W, van den Berg LH, Veldink JH, Ophoff R, Gusev A, Zaitlen N, McRae AF, Henderson RD, Wray NR, Giacomotto J, Garton FC. Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1. Genome Med. 2022 Jan 19;14(1):7. doi: 10.1186/s13073-021-01006-6.

Ovothiol ensures the correct developmental programme of the sea urchin Paracentrotus lividus embryo

Authors:
Milito A, Cocurullo M, Columbro A, Nonnis S, Tedeschi G, Castellano I, Arnone MI, Palumbo A
Citation:
Open Biol. 2022 Jan;12(1):210262. doi: 10.1098/rsob.210262. Epub 2022 Jan 19
Epub:
Not Epub
Abstract:
Ovothiols are π-methyl-5-thiohistidines produced in great amounts in sea urchin eggs, where they can act as protective agents...
Link:
https://royalsocietypublishing.org/doi/10.1098/rsob.210262
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Milito A, Cocurullo M, Columbro A, Nonnis S, Tedeschi G, Castellano I, Arnone MI, Palumbo A. Ovothiol ensures the correct developmental programme of the sea urchin Paracentrotus lividus embryo. Open Biol. 2022 Jan;12(1):210262. doi: 10.1098/rsob.210262. Epub 2022 Jan 19.

Neuron navigator 3 (NAV3) is required for heart development in zebrafish

Authors:
Lv F, Ge X, Qian P, Lu X, Liu D, Chen C
Citation:
Fish Physiol Biochem. 2022 Jan 18. doi: 10.1007/s10695-022-01049-5. Online ahead of print
Epub:
Not Epub
Abstract:
As a tightly controlled biological process, cardiogenesis requires the specification and migration of a suite of cell types to...
Link:
https://link.springer.com/article/10.1007%2Fs10695-022-01049-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lv F, Ge X, Qian P, Lu X, Liu D, Chen C. Neuron navigator 3 (NAV3) is required for heart development in zebrafish. Fish Physiol Biochem. 2022 Jan 18. doi: 10.1007/s10695-022-01049-5. Online ahead of print.

Systematic mapping of rRNA 2’-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis

Authors:
Delhermite J, Tafforeau L, Sharma S, Marchand V, Wacheul L, Lattuca R, Desiderio S, Motorin Y, Bellefroid E, Lafontaine DLJ
Citation:
PLoS Genet. 2022;18(1):e1010012. doi:10.1371/journal.pgen.1010012
Epub:
Not Epub
Abstract:
Ribosomes are essential nanomachines responsible for protein production. Although ribosomes are present in every living cell,...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010012
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Delhermite J, Tafforeau L, Sharma S, Marchand V, Wacheul L, Lattuca R, Desiderio S, Motorin Y, Bellefroid E, Lafontaine DLJ. Systematic mapping of rRNA 2’-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis. PLoS Genet. 2022;18(1):e1010012. doi:10.1371/journal.pgen.1010012.

Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle

Authors:
Levin JB, Borodinsky LN
Citation:
Cell Calcium. 2022;[Epub] doi:10.1016/j.ceca.2022.102540
Epub:
Yes
Abstract:
The transition of stem cells from quiescence to proliferation enables tissues to self-repair. The signaling mechanisms driving...
Link:
https://www.sciencedirect.com/science/article/pii/S014341602200015X
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Levin JB, Borodinsky LN. Injury-induced Erk1/2 signaling tissue-specifically interacts with Ca2+ activity and is necessary for regeneration of spinal cord and skeletal muscle. Cell Calcium. 2022;[Epub] doi:10.1016/j.ceca.2022.102540.

Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis

Authors:
Owen N, Toms M, Young RM, Eintracht J, Sarkar H, Brooks BP, Moosajee M; Genomics England Research Consortium
Citation:
Genet Med. 2022 Jan 13:S1098-3600(21)05473-3. doi: 10.1016/j.gim.2021.12.014. Online ahead of print
Epub:
Yes
Abstract:
Purpose: Ocular coloboma arises from genetic or environmental perturbations that inhibit optic fissure (OF) fusion during early...
Link:
https://www.sciencedirect.com/science/article/pii/S1098360021054733
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Owen N, Toms M, Young RM, Eintracht J, Sarkar H, Brooks BP, Moosajee M; Genomics England Research Consortium. Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Genet Med. 2022 Jan 13:S1098-3600(21)05473-3. doi: 10.1016/j.gim.2021.12.014. Online ahead of print.

Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RW(d)

Authors:
Lee H, Sun R, Niehrs C
Citation:
J Biol Chem. 2022 Jan 12:101586. doi: 10.1016/j.jbc.2022.101586. Online ahead of print
Epub:
Yes
Abstract:
Signaling by bone morphogenetic proteins (BMPs) plays pivotal roles in embryogenesis, adult tissue homeostasis, and disease....
Link:
https://www.sciencedirect.com/science/article/pii/S0021925822000266
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Lee H, Sun R, Niehrs C. Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RW(d). J Biol Chem. 2022 Jan 12:101586. doi: 10.1016/j.jbc.2022.101586. Online ahead of print.

Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis

Authors:
Tejeda-Muñoz N, Morselli M, Moriyama Y, Sheladiya P, Pellegrini M, De Robertis EM
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.01.11.475934
Epub:
Not Epub
Abstract:
During canonical Wnt signaling, the Lrp6 and Frizzled co-receptors bind to the Wnt growth factor and the complex is endocytosed...
Link:
https://www.biorxiv.org/content/10.1101/2022.01.11.475934v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Tejeda-Muñoz N, Morselli M, Moriyama Y, Sheladiya P, Pellegrini M, De Robertis EM. Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis. bioRxiv. 2022;[preprint] doi:10.1101/2022.01.11.475934.

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