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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins
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Citation:
J Clin Med. 2018 Dec 11;7(12). pii: E537. doi: 10.3390/jcm7120537 Epub:
Not Epub Abstract:
Lower extremities varicose veins (VV) are among the most easily recognized venous abnormalities. The genetic mechanism of VV is... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Hsieh CS, Tsai CT, Chen YH, Chang SN, Hwang JJ, Chuang EY, Wu IH. Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins. J Clin Med. 2018 Dec 11;7(12). pii: E537. doi: 10.3390/jcm7120537. |
The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis
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Citation:
Cell Rep. 2018;25(12):P3241-3251.e5. doi:10.1016/j.celrep.2018.11.055 Epub:
Not Epub Abstract:
Zebrafish have a high capacity to replace lost neurons after brain injury. New neurons involved in repair are generated by a... Delivery Method:
intacerebroventricular (icv) injection Organism or Cell Type:
zebrafish Citation Extract: Di Giaimo R, Durovic T, Barquin P, Kociaj A, Lepko T, Aschenbroich S, Breunig CT, Irmler M, Cernilogar FM, Schotta G, Barbosa JS, Tr€umbach D, Baumgart EV, Neuner AM, Beckers J, Wurst W, Stricker SH, Ninkovic J. The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis. Cell Rep. 2018;25(12):P3241-3251.e5. doi:10.1016/j.celrep.2018.11.055. |
Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV
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Citation:
Molec Ther Nucl Acids. 2018;[Epub] doi:10.1016/j.omtn.2018.12.001 Epub:
Yes Abstract:
The molecular chaperon MRJ (DNAJB6) exhibits two splice isoforms that have different roles in human viral infection, but the... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: HEK293T, THP-1, & Hep2 Citation Extract: Ko S-H, Liau Y-J, Chi Y-H, Lai M-J, Chiang Y-P, Lu C-Y, Chang L-Y, Tarn W-Y, Huang L-M. Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV. Molec Ther Nucl Acids. 2018;[Epub] doi:10.1016/j.omtn.2018.12.001. |
Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions
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Citation:
Toxicol Appl Pharmacol. 2018 Dec 12. pii: S0041-008X(18)30547-7. doi: 10.1016/j.taap.2018.12.009. [Epub ahead of print] Epub:
Not Epub Abstract:
Alternative splicing modulates gene function by creating splice variants with alternate functions or non-coding RNA activity.... Organism or Cell Type:
cell culture Citation Extract: Annalora AJ, Jozic M, Marcus CB, Iversen PL. Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions. Toxicol Appl Pharmacol. 2018 Dec 12. pii: S0041-008X(18)30547-7. doi: 10.1016/j.taap.2018.12.009. [Epub ahead of print]. |
The Spatio-Temporal Control of Zygotic Genome Activation
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Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/488056 Epub:
Not Epub Abstract:
One of the earliest events in embryonic development is zygotic genome activation (ZGA). According to nascent transcript... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Gentsch G, Owens NDL, Smith JC. The Spatio-Temporal Control of Zygotic Genome Activation. bioRxiv. 2018;[Preprint] doi:10.1101/488056. |
Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD
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Citation:
Mol Ther Nucleic Acids. 2018 Dec 7;13:1-15. doi: 10.1016/j.omtn.2018.08.005. Epub 2018 Aug 17 Epub:
Not Epub Abstract:
Extracellular small RNAs (sRNAs), including microRNAs (miRNAs), are promising biomarkers for diseases such as Duchenne muscular... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Coenen-Stass AML, Sork H, Gatto S, Godfrey C, Bhomra A, Krjutškov K, Hart JR, Westholm JO, O'Donovan L, Roos A, Lochmüller H, Puri PL, El Andaloussi S, Wood MJA, Roberts TC. Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD. Mol Ther Nucleic Acids. 2018 Dec 7;13:1-15. doi: 10.1016/j.omtn.2018.08.005. Epub 2018 Aug 17. |
Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1
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Citation:
Nat Commun. 2018 Dec 7;9(1):5227. doi: 10.1038/s41467-018-07517-y Epub:
Not Epub Abstract:
During drug development, tissue samples serve as indicators of disease activity and pharmacodynamic responses. Reliable non-... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
mice Citation Extract: Hu N, Antoury L, Baran TM, Mitra S, Bennett CF, Rigo F, Foster TH, Wheeler TM. Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1. Nat Commun. 2018 Dec 7;9(1):5227. doi: 10.1038/s41467-018-07517-y. |
Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model
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Citation:
Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018 Epub:
Not Epub Abstract:
Epilepsy is a neuronal dysfunction syndrome characterized by transient and diffusely abnormal discharges of neurons in the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zheng YM, Chen B, Jiang JD, Zhang JP. Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model. Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018. |
A transcriptomics analysis of the Tbx5 paralogues in zebrafish
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Citation:
PLoS ONE. 2018;13(12):e0208766. doi:10.1371/journal.pone.0208766 Epub:
Not Epub Abstract:
TBX5 is essential for limb and heart development. Mutations in TBX5 are associated with Holt-Oram syndrome in humans. Due to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Boyle Anderson EAT, Ho RK. A transcriptomics analysis of the Tbx5 paralogues in zebrafish. PLoS ONE. 2018;13(12):e0208766. doi:10.1371/journal.pone.0208766. |
Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure
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Citation:
Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5773-5784. doi: 10.1167/iovs.18-23962 Epub:
Not Epub Abstract:
Purpose: The optic fissure (OF) is a transient opening in the ventral optic cup (OC) that acts as a passage for blood vessels... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cao M, Ouyang J, Liang H, Guo J, Lin S, Yang S, Xie T, Chen S. Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5773-5784. doi: 10.1167/iovs.18-23962. |