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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Epigenetic inactivation of miR-203 as a key step in neural crest epithelial-to-mesenchymal transition

Authors:
Sánchez-Vásquez E, Bronner ME, Strobl-Mazzulla PH
Citation:
Development. 2019;[Epub ahead of print] doi:10.1242/dev.171017
Epub:
Yes
Abstract:
miR-203 is a tumor-suppressor microRNA with known functions in cancer metastasis. Here, we explore its normal developmental...
Link:
http://dev.biologists.org/content/early/2019/03/21/dev.171017
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Sánchez-Vásquez E, Bronner ME, Strobl-Mazzulla PH. Epigenetic inactivation of miR-203 as a key step in neural crest epithelial-to-mesenchymal transition. Development. 2019;[Epub ahead of print] doi:10.1242/dev.171017.

A threonyl-tRNA synthetase-mediated translation initiation machinery

Authors:
Jeong SJ, Park S, Nguyen LT, Hwang J, Lee E-Y, Giong H-K, Lee J-S, Yoon I, Lee J-H, Kim JH, Kim HK, Kim D, Yang WS, Kim S-Y, Lee CY, Yu K, Sonenberg N, Kim MH, Kim S
Citation:
Nat Comm. 2019;10:1357. doi:10.1038/s41467-019-09086-0
Epub:
Not Epub
Abstract:
A fundamental question in biology is how vertebrates evolved and differ from invertebrates, and little is known about...
Link:
https://www.nature.com/articles/s41467-019-09086-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jeong SJ, Park S, Nguyen LT, Hwang J, Lee E-Y, Giong H-K, Lee J-S, Yoon I, Lee J-H, Kim JH, Kim HK, Kim D, Yang WS, Kim S-Y, Lee CY, Yu K, Sonenberg N, Kim MH, Kim S. A threonyl-tRNA synthetase-mediated translation initiation machinery. Nat Comm. 2019;10:1357. doi:10.1038/s41467-019-09086-0.

A recurrent COL6A1 pseudoexon insertion causes muscular dystrophy and is effectively targeted by splice-correction therapies

Authors:
Bolduc V, Foley AR, Solomon-Degefa H, Sarathy A, Donkervoort S, Hu Y, Chen GS, Sizov K, Nalls M, Zhou H, Aguti S, Cummings BB, Lek M, Tukiainen T, Marshall JL, Regev O, Marek-Yagel D, Sarkozy A, Butterfield RJ, Jou C, Jimenez-Mallebrera C, Li Y, Gartioux C, Mamchaoui K, Allamand V, Gualandi F, Ferlini A, Hanssen E; COL6A1 Intron 11 Study Group, Wilton SD, Lamandé SR, MacArthur DG, Wagener R, Muntoni F, Bönnemann CG
Citation:
JCI Insight. 2019 Mar 21;4(6). pii: 124403. doi: 10.1172/jci.insight.124403. eCollection 2019 Mar 21
Epub:
Not Epub
Abstract:
The clinical application of advanced next-generation sequencing technologies is increasingly uncovering novel classes of...
Link:
https://insight.jci.org/articles/view/124403
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human dermal fibroblasts, HEK293T
Citation Extract:
Bolduc V, Foley AR, Solomon-Degefa H, Sarathy A, Donkervoort S, Hu Y, Chen GS, Sizov K, Nalls M, Zhou H, Aguti S, Cummings BB, Lek M, Tukiainen T, Marshall JL, Regev O, Marek-Yagel D, Sarkozy A, Butterfield RJ, Jou C, Jimenez-Mallebrera C, Li Y, Gartioux C, Mamchaoui K, Allamand V, Gualandi F, Ferlini A, Hanssen E; COL6A1 Intron 11 Study Group, Wilton SD, Lamandé SR, MacArthur DG, Wagener R, Muntoni F, Bönnemann CG. A recurrent COL6A1 pseudoexon insertion causes muscular dystrophy and is effectively targeted by splice-correction therapies. JCI Insight. 2019 Mar 21;4(6). pii: 124403. doi: 10.1172/jci.insight.124403. eCollection 2019 Mar 21.

Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish

Authors:
Cianciolo Cosentino C, Berto A, Pelletier S, Hari M, Loffing J, Neuhauss SCF, Doye V
Citation:
Sci Rep. 2019 Mar 18;9(1):4750. doi: 10.1038/s41598-019-41202-4
Epub:
Not Epub
Abstract:
Although structural nuclear pore proteins (nucleoporins) are seemingly required in every cell type to assemble a functional...
Link:
https://www.nature.com/articles/s41598-019-41202-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cianciolo Cosentino C, Berto A, Pelletier S, Hari M, Loffing J, Neuhauss SCF, Doye V. Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish. Sci Rep. 2019 Mar 18;9(1):4750. doi: 10.1038/s41598-019-41202-4.

Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway

Authors:
Neumann A, Schindler M, Olofsson D, Wilhelmi I, Schürmann A, Heyd F
Citation:
J Cell Sci. 2019 Mar 19. pii: jcs.230201. doi: 10.1242/jcs.230201. [Epub ahead of print]
Epub:
Yes
Abstract:
Alternative splicing (AS) strongly increases proteome diversity and functionality in eukaryotic cells. Protein secretion is a...
Link:
http://jcs.biologists.org/content/early/2019/03/18/jcs.230201.long
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture:HEK293T
Citation Extract:
Neumann A, Schindler M, Olofsson D, Wilhelmi I, Schürmann A, Heyd F. Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway. J Cell Sci. 2019 Mar 19. pii: jcs.230201. doi: 10.1242/jcs.230201. [Epub ahead of print].

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

Authors:
Cho S, Vashisth M, Abbas A, Majkutv S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang H-Y, Greenberg R, Prosser BL, Discher DE
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/583179
Epub:
Not Epub
Abstract:
Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely unclear. Here, acute perturbations (~...
Link:
https://www.biorxiv.org/content/10.1101/583179v1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
organ culture: Gallus gallus (chick) hearts
Citation Extract:
Cho S, Vashisth M, Abbas A, Majkutv S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang H-Y, Greenberg R, Prosser BL, Discher DE. Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest. bioRxiv. 2019;[preprint] doi:10.1101/583179.

Posterior axis formation requires Dlx5/Dlx6 expression at the neural plate border

Authors:
Narboux-Neme N, Ekker M, Levi G, Heude E
Citation:
PLoS ONE. 2019;14(3):e0214063. https://doi.org/10.1371/journal.pone.0214063
Epub:
Not Epub
Abstract:
Neural tube defects (NTDs), one of the most common birth defects in human, present a multifactorial etiology with a poorly...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214063
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Narboux-Neme N, Ekker M, Levi G, Heude E. Posterior axis formation requires Dlx5/Dlx6 expression at the neural plate border. PLoS ONE. 2019;14(3):e0214063. https://doi.org/10.1371/journal.pone.0214063.

Morpholino-induced exon skipping stimulates cell-mediated and humoral responses to dystrophin in mdx mice

Authors:
Vila MC, Novak JS, Benny Klimek M, Li N, Morales M, Fritz AG, Edwards K, Boehler JF, Hogarth MW, Kinder TB, Zhang A, Mazala D, Fiorillo AA, Douglas B, Chen YW, van den Anker J, Lu QL, Hathout Y, Hoffman EP, Partridge TA, Nagaraju K
Citation:
J Pathol. 2019 Mar 18. doi: 10.1002/path.5263. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Exon skipping is a promising genetic therapeutic strategy for restoring dystrophin expression in the treatment of Duchenne...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/path.5263
Organism or Cell Type:
mice mdx
Citation Extract:
Vila MC, Novak JS, Benny Klimek M, Li N, Morales M, Fritz AG, Edwards K, Boehler JF, Hogarth MW, Kinder TB, Zhang A, Mazala D, Fiorillo AA, Douglas B, Chen YW, van den Anker J, Lu QL, Hathout Y, Hoffman EP, Partridge TA, Nagaraju K. Morpholino-induced exon skipping stimulates cell-mediated and humoral responses to dystrophin in mdx mice. J Pathol. 2019 Mar 18. doi: 10.1002/path.5263. [Epub ahead of print].

Thrombocyte inhibition restores protective immunity to mycobacterial infection in zebrafish

Authors:
Hortle E, Johnson KE, Johansen MD, Nguyen T, Shavit JA, Britton WJ, Tobin DM, Oehlers SH
Citation:
J Infect Dis. 2019 Mar 16. pii: jiz110. doi: 10.1093/infdis/jiz110. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Infection-induced thrombocytosis is a clinically important complication of tuberculosis infection. Recent studies...
Link:
https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiz110/5381834
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hortle E, Johnson KE, Johansen MD, Nguyen T, Shavit JA, Britton WJ, Tobin DM, Oehlers SH. Thrombocyte inhibition restores protective immunity to mycobacterial infection in zebrafish. J Infect Dis. 2019 Mar 16. pii: jiz110. doi: 10.1093/infdis/jiz110. [Epub ahead of print].

Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Authors:
Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, Ljubimov VA, Shatalova ES, Wagner S, Li D, Mamelak AN, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Lyubimov AV, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY
Citation:
Cancer Res. 2019 Mar 15;79(6):1239-1251. doi: 10.1158/0008-5472.CAN-18-2725. Epub 2019 Jan 18
Epub:
Not Epub
Abstract:
. . . There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix, including...
Link:
http://cancerres.aacrjournals.org/content/79/6/1239
Delivery Method:
nanoparticles
Organism or Cell Type:
mice with glioblastome xenograft
Citation Extract:
Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, Ljubimov VA, Shatalova ES, Wagner S, Li D, Mamelak AN, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Lyubimov AV, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY. Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk. Cancer Res. 2019 Mar 15;79(6):1239-1251. doi: 10.1158/0008-5472.CAN-18-2725. Epub 2019 Jan 18.

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