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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12138 scientific papers returned from the database with the search filters currently being used below.

Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs

Authors:
Sazani P, Kang SH, Maier MA, Wei C, Dillman J, Summerton J, Manoharan M, Kole R
Citation:
Nucleic Acids Res. 2001 Oct 1;29(19):3965-74
Epub:
Not Epub
Abstract:
The antisense activity of oligomers with 2'-O-methyl (2'-O-Me) phosphorothioate, 2'-O-methoxyethyl (2'-O-...
Delivery Method:
scrape loading and free uptake
Organism or Cell Type:
cell culture: HeLa cells
Citation Extract:
Sazani P, Kang SH, Maier MA, Wei C, Dillman J, Summerton J, Manoharan M, Kole R. Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs. Nucleic Acids Res. 2001 Oct 1;29(19):3965-74.

olig1 expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling

Authors:
Schebesta M, Serluca FC
Citation:
Dev Dyn. 2009 Feb 27. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Myelin, the isolating sheath around large diameter axons, is formed in the central nervous system (CNS) by oligodendrocytes. We...
Organism or Cell Type:
zebrafish
Citation Extract:
Schebesta M, Serluca FC. olig1 expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling. Dev Dyn. 2009 Feb 27. [Epub ahead of print].

Prohibitin1 acts as a neural crest specifier in Xenopus development by repressing the transcription factor E2F1

Authors:
Schneider M, Schambony A, Wedlich D
Citation:
Development. 2010 Dec;137(23):4073-81
Epub:
Not Epub
Abstract:
Prohibitin 1 (phb1), which was initially described as an inhibitor of cell proliferation, is a highly conserved protein found...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Schneider M, Schambony A, Wedlich D. Prohibitin1 acts as a neural crest specifier in Xenopus development by repressing the transcription factor E2F1. Development. 2010 Dec;137(23):4073-81.

Quantitative evaluation of morpholino-mediated protein knockdown of GFP, MSX1, and PAX7 during tail regeneration in Ambystoma mexicanum

Authors:
Schnapp E, Tamaka EM
Citation:
Dev Dyn. 2005 Jan;232(1):162-70.
Epub:
Not Epub
Abstract:
Vertebrate regeneration is a fascinating but poorly understood biological phenomena. Urodele amphibians such as Ambystoma...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/dvdy.20203
Delivery Method:
Electroporation
Organism or Cell Type:
Ambystoma mexicanum (axolotl)
Citation Extract:
Schnapp E, Tamaka EM. Quantitative evaluation of morpholino-mediated protein knockdown of GFP, MSX1, and PAX7 during tail regeneration in Ambystoma mexicanum. Dev Dyn. 2005 Jan;232(1):162-70..

Repeat-Dose Toxicology Evaluation in Cynomolgus Monkeys of AVI-4658, a Phosphorodiamidate Morpholino Oligomer (PMO) Drug for the Treatment of Duchenne Muscular Dystrophy

Authors:
Sazani P, Van Ness KP, Weller DL, Poage DW, Palyada K, Shrewsbury SB
Citation:
Int J Toxicol. 2011 May 3. [Epub ahead of print]
Epub:
Not Epub
Abstract:
AVI-4658 is a phosphorodiamidate morpholino oligomer (PMO) drug designed to restore dystrophin expression in a subset of...
Link:
http://journals.sagepub.com/doi/abs/10.1177/1091581811403505?journalCode=ijtb
Delivery Method:
Intravenous (i.v.) or subcutaneous (s.c.)
Organism or Cell Type:
monkey, cynomolgus
Citation Extract:
Sazani P, Van Ness KP, Weller DL, Poage DW, Palyada K, Shrewsbury SB. Repeat-Dose Toxicology Evaluation in Cynomolgus Monkeys of AVI-4658, a Phosphorodiamidate Morpholino Oligomer (PMO) Drug for the Treatment of Duchenne Muscular Dystrophy. Int J Toxicol. 2011 May 3. [Epub ahead of print].

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

Authors:
Scaffidi P, Misteli T
Citation:
Nat Med. 2005 Apr;11(4):440-5. Epub 2005 Mar 6
Epub:
Not Epub
Abstract:
Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in...
Link:
http://www.nature.com/nm/journal/v11/n4/full/nm1204.html
Delivery Method:
Electroporation
Organism or Cell Type:
cell culture: primary human fibroblast, lymphoblastoid lines
Citation Extract:
Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med. 2005 Apr;11(4):440-5. Epub 2005 Mar 6.

Safety Pharmacology and Genotoxicity Evaluation of AVI-4658

Authors:
Sazani P, Weller DL, Shrewsbury SB
Citation:
Int J Toxicol. 2010 Jan 28. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is caused by dystrophin gene mutations. Restoration of dystrophin by exon skipping was...
Link:
http://journals.sagepub.com/doi/abs/10.1177/1091581809359206
Organism or Cell Type:
Mouse, cynomolgus monkey
Citation Extract:
Sazani P, Weller DL, Shrewsbury SB. Safety Pharmacology and Genotoxicity Evaluation of AVI-4658. Int J Toxicol. 2010 Jan 28. [Epub ahead of print].

Site-1 protease is required for cartilage development in zebrafish

Authors:
Schlombs K, Wagner T, Scheel J
Citation:
Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14024-9. Epub 2003 Nov 11.
Epub:
Not Epub
Abstract:
gonzo (goz) is a zebrafish mutant with defects in cartilage formation. The goz phenotype comprises cartilage matrix defects and...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schlombs K, Wagner T, Scheel J. Site-1 protease is required for cartilage development in zebrafish. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14024-9. Epub 2003 Nov 11..

SKY1 is involved in cisplatin-induced cell kill in Saccharomyces cerevisiae, and inactivation of its human homologue, SRPK1, induces cisplatin resistance in a human ovarian carcinoma cell line.

Authors:
Schenk PW, Boersma AW, Brandsma JA, den Dulk H, Burger H, Stoter G, Brouwer J, Nooter K.
Citation:
Cancer Res. 2001 Oct 1;61(19):6982-6
Epub:
Not Epub
Abstract:
The therapeutic potential of cisplatin, one of the most active and widely used anticancer drugs, is severely limited by the...
Delivery Method:
Special Delivery
Organism or Cell Type:
cell culture: human ovarian carcinoma A2780 cell line
Citation Extract:
Schenk PW, Boersma AW, Brandsma JA, den Dulk H, Burger H, Stoter G, Brouwer J, Nooter K.. SKY1 is involved in cisplatin-induced cell kill in Saccharomyces cerevisiae, and inactivation of its human homologue, SRPK1, induces cisplatin resistance in a human ovarian carcinoma cell line.. Cancer Res. 2001 Oct 1;61(19):6982-6.

Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish

Authors:
Saxena A, Peng BN, Bronner ME
Citation:
eLife. 2013;2:e00336 doi:10.7554/eLife.00336
Epub:
Not Epub
Abstract:
The sense of smell in vertebrates is detected by specialized sensory neurons derived from the peripheral nervous system....
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Saxena A, Peng BN, Bronner ME. Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish. eLife. 2013;2:e00336 doi:10.7554/eLife.00336.

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