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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

Authors:
Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH
Citation:
Nat Commun. 2013 Jul 17;4:2180. doi: 10.1038/ncomms3180
Epub:
Not Epub
Abstract:
The Hace1-HECT E3 ligase is a tumor suppressor that ubiquitylates the activated GTP-bound form of the Rho family GTPase Rac1,...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH. Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nat Commun. 2013 Jul 17;4:2180. doi: 10.1038/ncomms3180.

Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton

Authors:
DeLaurier A, Nakamura Y, Braasch I, Khanna V, Kato H, Wakitani S, Postlethwait JH, Kimmel CB
Citation:
BMC Dev Biol. 2012;12:16 doi:10.1186/1471-213X-12-16
Epub:
Not Epub
Abstract:
Background Histone deacetylase-4 (Hdac4) is a class II histone deacetylase that inhibits the activity of transcription factors...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
DeLaurier A, Nakamura Y, Braasch I, Khanna V, Kato H, Wakitani S, Postlethwait JH, Kimmel CB. Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Dev Biol. 2012;12:16 doi:10.1186/1471-213X-12-16.

Identification and functional analysis of endothelial tip cell-enriched genes

Authors:
Del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A
Citation:
Blood. 2010 Aug 12. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Sprouting of developing blood vessels is mediated by specialized motile endothelial cells localized at the tips of growing...
Organism or Cell Type:
zebrafish
Citation Extract:
Del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A. Identification and functional analysis of endothelial tip cell-enriched genes. Blood. 2010 Aug 12. [Epub ahead of print].

Identifying axon guidance defects in the embryonic zebrafish brain

Authors:
Devine CA, Key B
Citation:
Methods in Cell Science. 2003; 25(1-2):33-37
Epub:
Not Epub
Abstract:
The method described here outlines a simple protocol to investigate the in vivo function of axon guidance molecules during the...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Devine CA, Key B. Identifying axon guidance defects in the embryonic zebrafish brain. Methods in Cell Science. 2003; 25(1-2):33-37.

In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus

Authors:
Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY
Citation:
Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7
Epub:
Not Epub
Abstract:
We characterize the in vitro resistance and demonstrate the in vivo efficacy of two antisense phosphorodiamidate-morpholino-...
Link:
http://aac.asm.org/content/51/7/2470.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Flavivirus in cell culture and mice
Citation Extract:
Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY. In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus. Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7.

In vivo Bioavailability and Pharmacokinetics of a c-MYC Antisense Phosphorodiamidate Morpholino Oligomer, AVI-4126, in Solid Tumors

Authors:
Devi GR, Beer TM, Corless CL, Arora V, Weller DL, Iversen PL
Citation:
Clin Cancer Res. 2005 May 15;11(10):3930-8
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMO) inhibit targeted gene expression by preventing ribosomal assembly, thereby...
Link:
https://aacrjournals.org/clincancerres/article/11/10/3930/186123/In-vivo-Bioavailability-and-Pharmacokinetics-of-a
Delivery Method:
culture: scrape loading and syringe loading; mouse: IP injection
Organism or Cell Type:
cultures & mice: human DU145, PC-3, LNCaP prostate cancer lines, male athymic (Ncr nu/nu) mice
Citation Extract:
Devi GR, Beer TM, Corless CL, Arora V, Weller DL, Iversen PL. In vivo Bioavailability and Pharmacokinetics of a c-MYC Antisense Phosphorodiamidate Morpholino Oligomer, AVI-4126, in Solid Tumors. Clin Cancer Res. 2005 May 15;11(10):3930-8.

In Vivo Efficacy of Phosphorodiamidate Morpholino-Based Antisense Oligomers in Tumor and Angiogenesis Models

Authors:
Devi G
Citation:
Cancer Gene Therapy, 2003, vol. 10, no. SUPP/1, pp. 9
Epub:
Not Epub
Citation Extract:
Devi G. In Vivo Efficacy of Phosphorodiamidate Morpholino-Based Antisense Oligomers in Tumor and Angiogenesis Models. Cancer Gene Therapy, 2003, vol. 10, no. SUPP/1, pp. 9.

In vivo validation of a computationally predicted conserved Ath5 target gene set

Authors:
Del Bene F, Ettwiller L, Skowronska-Krawczyk D, Baier H, Matter JM, Birney E, Wittbrodt J
Citation:
PLoS Genet. 2007 Sep 21;3(9):1661-71. Epub 2007 Aug 1
Epub:
Not Epub
Abstract:
So far, the computational identification of transcription factor binding sites is hampered by the complexity of vertebrate...
Organism or Cell Type:
medaka embryos
Citation Extract:
Del Bene F, Ettwiller L, Skowronska-Krawczyk D, Baier H, Matter JM, Birney E, Wittbrodt J. In vivo validation of a computationally predicted conserved Ath5 target gene set. PLoS Genet. 2007 Sep 21;3(9):1661-71. Epub 2007 Aug 1.

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

Authors:
Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY
Citation:
J Virol. 2005 Apr;79(8):4599-609
Epub:
Not Epub
Abstract:
RNA elements within flavivirus genomes are potential targets for antiviral therapy. A panel of phosphorodiamidate morpholino...
Link:
http://jvi.asm.org/content/79/8/4599.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
West Nile Virus
Citation Extract:
Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol. 2005 Apr;79(8):4599-609.

Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells

Authors:
Devi GR, Oldenkamp JR, London CA, Iversen PL
Citation:
Prostate. 2002 Nov 1;53(3):200-10
Epub:
Not Epub
Abstract:
BACKGROUND: Amplification of the proto-oncogene c-myc has been identified as one of the most common genetic alterations in...
Delivery Method:
culture: scrape loading and syringe loading; mouse: IP injection
Organism or Cell Type:
cultures & mice: human DU145, PC-3, LNCaP prostate cancer lines, male athymic (Ncr nu/nu) mice
Citation Extract:
Devi GR, Oldenkamp JR, London CA, Iversen PL. Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells. Prostate. 2002 Nov 1;53(3):200-10.

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