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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Xbra modulates the activity of linker region phosporlated Smad1 during Xenopus somitogenesis

Authors:
Kim J, Kumar S, Umair Z, Goutam RS, Lee U
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.11.561863
Epub:
Not Epub
Abstract:
The Bmp/Smad1 pathway plays a crucial role in developmental processes and tissue homeostasis. Mitogen-activated protein kinase...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.11.561863v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim J, Kumar S, Umair Z, Goutam RS, Lee U. Xbra modulates the activity of linker region phosporlated Smad1 during Xenopus somitogenesis. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.11.561863.

Rtf1-dependent transcriptional pausing regulates cardiogenesis

Authors:
Langenbacher AD, Fei Lu, Tsang L, Yi Z, Huang S, Keer B, Tian X, Eide A, Pellegrini M, Nakano H, Nakano A, Chen J-N
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.13.562296
Epub:
Not Epub
Abstract:
During heart development, a well-characterized network of transcription factors initiates cardiac gene expression and defines...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.13.562296v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Langenbacher AD, Fei Lu, Tsang L, Yi Z, Huang S, Keer B, Tian X, Eide A, Pellegrini M, Nakano H, Nakano A, Chen J-N. Rtf1-dependent transcriptional pausing regulates cardiogenesis. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.13.562296.

Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs

Authors:
Das A, Ghosh A, Kundu J, Egli M, Manoharan M, Sinha S
Citation:
J Org Chem. 2023 Oct 16. doi: 10.1021/acs.joc.3c01658. Online ahead of print
Epub:
Yes
Abstract:
Successful syntheses of chlorophosphoramidate morpholino monomers containing tricyclic cytosine analogs phenoxazine, G-clamp,...
Link:
https://pubs.acs.org/doi/10.1021/acs.joc.3c01658
Citation Extract:
Das A, Ghosh A, Kundu J, Egli M, Manoharan M, Sinha S. Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs. J Org Chem. 2023 Oct 16. doi: 10.1021/acs.joc.3c01658. Online ahead of print.

Crb3 is required to organize the apical domain of multiciliated cells

Authors:
Burcklé C, Raitière J, Michaux G, Kodjabachian L, Bivic AL
Citation:
J Cell Sci. 2023 Oct 16:jcs.261046. doi: 10.1242/jcs.261046. Online ahead of print
Epub:
Yes
Abstract:
Cell shape changes mainly rely on the remodeling of the actin cytoskeleton. Multiciliated cells (MCCs) of the mucociliary...
Link:
https://journals.biologists.com/jcs/article-abstract/doi/10.1242/jcs.261046/333513/Crb3-is-required-to-organize-the-apical-domain-of
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Burcklé C, Raitière J, Michaux G, Kodjabachian L, Bivic AL. Crb3 is required to organize the apical domain of multiciliated cells. J Cell Sci. 2023 Oct 16:jcs.261046. doi: 10.1242/jcs.261046. Online ahead of print.

Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors

Authors:
Gambles MT, Sborov D, Shami P, Yang J, Kopeček J
Citation:
Macromol Biosci. 2023 Oct 15:e2300375. doi: 10.1002/mabi.202300375. Online ahead of print
Epub:
Yes
Abstract:
Drug-Free Macromolecular Therapeutics (DFMT) utilizes modified monoclonal antibodies (or antibody fragments) to generate...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mabi.202300375
Delivery Method:
cell bathing; injection
Organism or Cell Type:
cell culture: Raji (B cells); mice
Citation Extract:
Gambles MT, Sborov D, Shami P, Yang J, Kopeček J. Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors. Macromol Biosci. 2023 Oct 15:e2300375. doi: 10.1002/mabi.202300375. Online ahead of print.

Chaperone-mediated autophagy protects against hyperglycemic stress

Authors:
Vélez EJ, Schnebert S, Goguet M, Balbuena-Pecino S, Dias K, Beauclair L, Fontagné-Dicharry S, Véron V, Depincé A, Beaumatin F, Herpin A, Seiliez I
Citation:
Autophagy. 2023 Oct 5:[Epub ahead of print]. doi:10.1080/15548627.2023.2267415
Epub:
Yes
Abstract:
Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homeostasis and metabolism...
Link:
https://www.tandfonline.com/doi/figure/10.1080/15548627.2023.2267415
Organism or Cell Type:
Oncorhynchus mykiss (rainbow trout)
Citation Extract:
Vélez EJ, Schnebert S, Goguet M, Balbuena-Pecino S, Dias K, Beauclair L, Fontagné-Dicharry S, Véron V, Depincé A, Beaumatin F, Herpin A, Seiliez I. Chaperone-mediated autophagy protects against hyperglycemic stress. Autophagy. 2023 Oct 5:[Epub ahead of print]. doi:10.1080/15548627.2023.2267415.

Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification

Authors:
Hu P, Wang B, Jin D, Gu Y, He H, Meng X, Zhu W, Chiang DY, Li W, MacRae CA, Zu Y
Citation:
Cell Mol Life Sci. 2023;80:317. doi:10.1007/s00018-023-04933-2
Epub:
Not Epub
Abstract:
Hox genes orchestrate the segmental specification of the muscular circulatory system in invertebrates but it has not proven...
Link:
https://link.springer.com/article/10.1007/s00018-023-04933-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hu P, Wang B, Jin D, Gu Y, He H, Meng X, Zhu W, Chiang DY, Li W, MacRae CA, Zu Y. Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification. Cell Mol Life Sci. 2023;80:317. doi:10.1007/s00018-023-04933-2.

An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis

Authors:
González-Llera L, Sobrido-Cameán D, Quelle-Regaldie A, Sánchez L, Barreiro-Iglesias A
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.05.561099
Epub:
Not Epub
Abstract:
The study of neurogenesis is essential to understand fundamental developmental processes and for the development of cell...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.05.561099v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
González-Llera L, Sobrido-Cameán D, Quelle-Regaldie A, Sánchez L, Barreiro-Iglesias A. An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.05.561099.

P29 DMD transcript imbalance and nuclear trafficking evaluation in muscle biopsies from baseline and golodirsen treated 4053-101 clinical trial patients

Authors:
Rossi R, Singh S, Torelli S, Catapano F, Chambers D, Morgan J, Malhotra J, Muntoni F
Citation:
Neuromuscul Disord. 2023;33(Supp 1):S104. doi:10.1016/j.nmd.2023.07.156
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked, rare, neuromuscular disease caused by mutations in the DMD gene affecting its...
Link:
https://www.nmd-journal.com/article/S0960-8966(23)00336-X/pdf
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Rossi R, Singh S, Torelli S, Catapano F, Chambers D, Morgan J, Malhotra J, Muntoni F. P29 DMD transcript imbalance and nuclear trafficking evaluation in muscle biopsies from baseline and golodirsen treated 4053-101 clinical trial patients. Neuromuscul Disord. 2023;33(Supp 1):S104. doi:10.1016/j.nmd.2023.07.156.

P23 Evaluation of safety parameters and dystrophin expression by sequential administration of exon-skipping and gene therapy in a DMDmdx mouse model

Authors:
Potter R, Cooper Olson GC, Smith L, Greve J, Haile A, Wier C, Snedeker J, Burch P, Hunter B, Malmberg A, Rodino-Klapac L
Citation:
Neuromuscul Disord. 2023;33(Supp 1):S102-3. doi:10.1016/j.nmd.2023.07.150
Epub:
Not Epub
Abstract:
There are promising treatment approaches emerging for Duchenne muscular dystrophy (DMD): exon skipping with peptide-conjugated...
Link:
https://www.nmd-journal.com/article/S0960-8966(23)00330-9/pdf
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Potter R, Cooper Olson GC, Smith L, Greve J, Haile A, Wier C, Snedeker J, Burch P, Hunter B, Malmberg A, Rodino-Klapac L. P23 Evaluation of safety parameters and dystrophin expression by sequential administration of exon-skipping and gene therapy in a DMDmdx mouse model. Neuromuscul Disord. 2023;33(Supp 1):S102-3. doi:10.1016/j.nmd.2023.07.150.

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