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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses

Authors:
Isenberg JS, Annis DS, Pendrak ML, Ptaszynska M, Frazier WA, Mosher DF, Roberts DD
Citation:
J Biol Chem. 2009 Jan 9;284(2):1116-25. Epub 2008 Nov 11
Epub:
Not Epub
Abstract:
Thrombospondin-1 regulates nitric oxide (NO) signaling in vascular cells via CD47. Because CD47 binding motifs are conserved in...
Organism or Cell Type:
cell culture: primary TSP1-null vascular cells
Citation Extract:
Isenberg JS, Annis DS, Pendrak ML, Ptaszynska M, Frazier WA, Mosher DF, Roberts DD. Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. J Biol Chem. 2009 Jan 9;284(2):1116-25. Epub 2008 Nov 11.

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

Authors:
Iversen PL, Warren TK, Wells JB, Garza NL, Mourich DV, Welch LS, Panchal RG, Bavari S
Citation:
Viruses. 2012;4(11):2806-2830. doi:10.3390/v4112806
Epub:
Not Epub
Abstract:
There are no currently approved treatments for filovirus infections. In this study we report the discovery process which led to...
Link:
http://www.mdpi.com/1999-4915/4/11/2806
Organism or Cell Type:
Ebola and Marburg virus, various hosts
Citation Extract:
Iversen PL, Warren TK, Wells JB, Garza NL, Mourich DV, Welch LS, Panchal RG, Bavari S. Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections. Viruses. 2012;4(11):2806-2830. doi:10.3390/v4112806.

Effect of morpholino antisense oligonucleotide against lumican mRNA in human embryonic kidney (HEK) 293 cells

Authors:
Ishiwata T, Fujii T, Ishiwata S, Ikegawa S, Naito Z
Citation:
Pathol Int. 2004 Feb; 54(2): 77-81
Epub:
Not Epub
Abstract:
Lumican is a member of the small-leucine-rich proteoglycan (SLRP) family and is overexpressed during wound healing of the...
Delivery Method:
Special Delivery
Organism or Cell Type:
cell culture: human embryonic kidney (HEK 293)
Citation Extract:
Ishiwata T, Fujii T, Ishiwata S, Ikegawa S, Naito Z. Effect of morpholino antisense oligonucleotide against lumican mRNA in human embryonic kidney (HEK) 293 cells. Pathol Int. 2004 Feb; 54(2): 77-81.

Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans

Authors:
Iversen PL, Arora V, Acker AJ, Mason DH, Devi GR
Citation:
Clin Cancer Res. 2003 Jul;9(7):2510-9
Epub:
Not Epub
Abstract:
PURPOSE: The overexpression of c-myc associated with uncontrolled cell proliferation is a frequent genetic event in androgen-...
Delivery Method:
Special Delivery
Organism or Cell Type:
Cell Culture: PC-3 human androgen-independent prostate carcinoma
Citation Extract:
Iversen PL, Arora V, Acker AJ, Mason DH, Devi GR. Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. Clin Cancer Res. 2003 Jul;9(7):2510-9.

Emergence of traveling waves in the zebrafish segmentation clock

Authors:
Ishimatsu K, Takamatsu A, Takeda H
Citation:
Development. 2010 May;137(10):1595-9. doi: 10.1242/dev.046888. Epub 2010 Apr 14.
Epub:
Not Epub
Abstract:
The spatial and temporal periodicity of somite formation is controlled by the segmentation clock, in which numerous cells...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ishimatsu K, Takamatsu A, Takeda H. Emergence of traveling waves in the zebrafish segmentation clock. Development. 2010 May;137(10):1595-9. doi: 10.1242/dev.046888. Epub 2010 Apr 14..

Evaluation of Antisense Mechanisms of Action

Authors:
Iversen P, Ghosh C, Stein D, Weller D
Citation:
Antisense Technology, Part A, General Methods, Methods of Delivery, and RNA Studies. Phillips I, Abelson J, Simon M eds. Methods in Enzymology. 1999 313:
Epub:
Not Epub
Abstract:
Citation Extract:
Iversen P, Ghosh C, Stein D, Weller D. Evaluation of Antisense Mechanisms of Action. Antisense Technology, Part A, General Methods, Methods of Delivery, and RNA Studies. Phillips I, Abelson J, Simon M eds. Methods in Enzymology. 1999 313:.

Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos

Authors:
Ishibashi H, Matsumura N, Hanafusa H, Matsumoto K, Robertis EM, Kuroda H
Citation:
Mech Dev. 2008 Jan-Feb;125(1-2):58-66. Epub 2007 Oct 12
Epub:
Not Epub
Abstract:
The blastula Chordin- and Noggin-expressing (BCNE) center located in the dorsal animal region of the Xenopus blastula embryo...
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ishibashi H, Matsumura N, Hanafusa H, Matsumoto K, Robertis EM, Kuroda H. Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos. Mech Dev. 2008 Jan-Feb;125(1-2):58-66. Epub 2007 Oct 12.

Fbxw7 Controls Angiogenesis by Regulating Endothelial Notch Activity

Authors:
Izumi N, Helker C, Ehling M, Behrens A, Herzog W, Adams RH
Citation:
PLoS ONE. 2012;7(7):e41116. doi:10.1371/journal.pone.0041116
Epub:
Not Epub
Abstract:
Notch signaling controls fundamental aspects of angiogenic blood vessel growth including the selection of sprouting tip cells,...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Izumi N, Helker C, Ehling M, Behrens A, Herzog W, Adams RH. Fbxw7 Controls Angiogenesis by Regulating Endothelial Notch Activity. PLoS ONE. 2012;7(7):e41116. doi:10.1371/journal.pone.0041116.

FGF4 regulates blood and muscle specification in Xenopus laevis

Authors:
Isaacs HV, Deconinck AE, Pownall ME
Citation:
Biol Cell. 2007 Mar;99(3):165-73
Epub:
Not Epub
Abstract:
Background information: FGF signaling is known to be required for many aspects of mesoderm formation and patterning during...
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Isaacs HV, Deconinck AE, Pownall ME. FGF4 regulates blood and muscle specification in Xenopus laevis. Biol Cell. 2007 Mar;99(3):165-73.

Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model: Implications for human disease.

Authors:
Isenberg JS, Romeo MJ, Maxhimer JB, Smedley J, Frazier WA, Roberts DD
Citation:
Ann. Surg. 247(5):860-868, 2008.
Epub:
Not Epub
Abstract:
BACKGROUND: Insufficient tissue perfusion underlies many acute and chronic diseases. Tissue perfusion in turn requires adequate...
Delivery Method:
in vivo: injection
Organism or Cell Type:
pig
Citation Extract:
Isenberg JS, Romeo MJ, Maxhimer JB, Smedley J, Frazier WA, Roberts DD. Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model: Implications for human disease.. Ann. Surg. 247(5):860-868, 2008..

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