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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy

Authors:
Blain AM, Greally E, McClorey G, Manzano R, Betts CA, Godfrey C, O'Donovan L, Coursindel T, Gait MJ, Wood MJ, MacGowan GA, Straub VW
Citation:
PLoS One. 2018 Jun 18;13(6):e0198897. doi: 10.1371/journal.pone.0198897. eCollection 2018
Epub:
Not Epub
Abstract:
Blain AM, Greally E, McClorey G, Manzano R, Betts CA, Godfrey C, O'Donovan L, Coursindel T, Gait MJ, Wood MJ, MacGowan GA...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198897
Delivery Method:
peptide-linked
Organism or Cell Type:
mice mdx
Citation Extract:
Blain AM, Greally E, McClorey G, Manzano R, Betts CA, Godfrey C, O'Donovan L, Coursindel T, Gait MJ, Wood MJ, MacGowan GA, Straub VW. Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy. PLoS One. 2018 Jun 18;13(6):e0198897. doi: 10.1371/journal.pone.0198897. eCollection 2018.

Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly

Authors:
Li D, Wenger TL, Seiler C, March ME, Gutierrez-Uzquiza A, Kao C, Bhoj E, Tian L, Rosenbach M, Liu Y, Robinson N, Behr M, Chiavacci R, Hou C, Wang T, Bakay M, Pellegrino da Silva R, Perkins JA, Sleiman P, Levine MA, Hicks PJ, Itkin M, Dori Y, Hakonarson H
Citation:
Hum Mol Genet. 2018 Jun 14. doi: 10.1093/hmg/ddy218. [Epub ahead of print]
Epub:
Yes
Abstract:
Central conducting lymphatic anomaly (CCLA) is one of the complex lymphatic anomalies characterized by dilated lymphatic...
Link:
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddy218/5037907
Organism or Cell Type:
zebrafish
Citation Extract:
Li D, Wenger TL, Seiler C, March ME, Gutierrez-Uzquiza A, Kao C, Bhoj E, Tian L, Rosenbach M, Liu Y, Robinson N, Behr M, Chiavacci R, Hou C, Wang T, Bakay M, Pellegrino da Silva R, Perkins JA, Sleiman P, Levine MA, Hicks PJ, Itkin M, Dori Y, Hakonarson H. Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly. Hum Mol Genet. 2018 Jun 14. doi: 10.1093/hmg/ddy218. [Epub ahead of print].

LHX2 Mediates the FGF-to-SHH Regulatory Loop during Limb Development

Authors:
Watson BA, Feenstra JM, Van Arsdale JM, Rai-Bhatti KS, Kim DJH, Coggins AS, Mattison GL, Yoo S, Steinman ED, Pira CU, Gongol BR, Oberg KC
Citation:
J Dev Biol. 2018 Jun 15;6(2). pii: E13. doi: 10.3390/jdb6020013
Epub:
Not Epub
Abstract:
During limb development, fibroblast growth factors (Fgfs) govern proximal⁻distal outgrowth and patterning. FGFs also...
Link:
http://www.mdpi.com/2221-3759/6/2/13/htm
Delivery Method:
injection and electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Watson BA, Feenstra JM, Van Arsdale JM, Rai-Bhatti KS, Kim DJH, Coggins AS, Mattison GL, Yoo S, Steinman ED, Pira CU, Gongol BR, Oberg KC. LHX2 Mediates the FGF-to-SHH Regulatory Loop during Limb Development. J Dev Biol. 2018 Jun 15;6(2). pii: E13. doi: 10.3390/jdb6020013.

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Authors:
Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP
Citation:
Nat Comm. 2018;2292(9):[Epub] doi:10.1038/s41467-018-04602-0
Epub:
Not Epub
Abstract:
Oxidized phospholipids (oxPAPC) induce endothelial dysfunction and atherosclerosis. Here we show that oxPAPC induce a gene...
Link:
https://www.nature.com/articles/s41467-018-04602-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nat Comm. 2018;2292(9):[Epub] doi:10.1038/s41467-018-04602-0.

ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells

Authors:
Hofsteen P, Robitaille AM, Strash N, Palpant N, Moon RT, Pabon L, Murry CE
Citation:
iScience. 2018 Apr 27;2:88-100. doi: 10.1016/j.isci.2018.03.010
Epub:
Not Epub
Abstract:
Cardiac development requires coordinated biphasic regulation of the WNT/β-catenin signaling pathway. By intersecting gene...
Link:
https://www.cell.com/iscience/abstract/S2589-0042(18)30019-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hofsteen P, Robitaille AM, Strash N, Palpant N, Moon RT, Pabon L, Murry CE. ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. iScience. 2018 Apr 27;2:88-100. doi: 10.1016/j.isci.2018.03.010.

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins

Authors:
Chi B, O'Connell JD, Yamazaki T, Gangopadhyay J, Gygi SP, Reed R
Citation:
Sci Rep. 2018 Jun 8;8(1):8755. doi: 10.1038/s41598-018-27136-3
Epub:
Not Epub
Abstract:
Mutations in multiple RNA/DNA binding proteins cause Amyotrophic Lateral Sclerosis (ALS). Included among these are the three...
Link:
https://www.nature.com/articles/s41598-018-27136-3
Organism or Cell Type:
cell-free: HeLa nuclear extract
Citation Extract:
Chi B, O'Connell JD, Yamazaki T, Gangopadhyay J, Gygi SP, Reed R. Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins. Sci Rep. 2018 Jun 8;8(1):8755. doi: 10.1038/s41598-018-27136-3.

Controlling Cell Fate Specification System by Key Genes Determined from Network Structure

Authors:
Kobayashi K, Maeda K, Tokuoka M, Mochizuki A, Satou Y
Citation:
iScience. 2018;4:281-93. doi:10.1016/j.isci.2018.05.004
Epub:
Yes
Abstract:
Network structures describing regulation between biomolecules have been determined in many biological systems. Dynamics of...
Link:
https://www.sciencedirect.com/science/article/pii/S2589004218300592
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Kobayashi K, Maeda K, Tokuoka M, Mochizuki A, Satou Y. Controlling Cell Fate Specification System by Key Genes Determined from Network Structure. iScience. 2018;4:281-93. doi:10.1016/j.isci.2018.05.004.

HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

Authors:
Swaroop S, Mahadevan A, Shankar SK, Adlakha YK, Basu A
Citation:
J Neuroinflammation. 2018 Jun 9;15(1):177. doi: 10.1186/s12974-018-1214-5
Epub:
Not Epub
Abstract:
BACKGROUND: Interleukin-1β (IL-1β) is one of the most important cytokine secreted by activated microglia as it orchestrates the...
Link:
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1214-5
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
BALB/c mice
Citation Extract:
Swaroop S, Mahadevan A, Shankar SK, Adlakha YK, Basu A. HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway. J Neuroinflammation. 2018 Jun 9;15(1):177. doi: 10.1186/s12974-018-1214-5.

Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo

Authors:
Ellett F, Pazhakh V, Pase L, Benard EL, Weerasinghe H, Azabdaftari D, Alasmari S, Andrianopoulos A, Lieschke GJ
Citation:
PLoS Pathog. 2018 Jun 8;14(6):e1007063. doi: 10.1371/journal.ppat.1007063. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Neutrophils and macrophages provide the first line of cellular defence against pathogens once physical barriers are breached,...
Link:
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007063
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ellett F, Pazhakh V, Pase L, Benard EL, Weerasinghe H, Azabdaftari D, Alasmari S, Andrianopoulos A, Lieschke GJ. Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo. PLoS Pathog. 2018 Jun 8;14(6):e1007063. doi: 10.1371/journal.ppat.1007063. [Epub ahead of print].

Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation

Authors:
Ashikov A, Abu Bakar N, Wen XY, Niemeijer M, Rodrigues Pinto Osorio G, Brand-Arzamendi K, Hasadsri L, Hansikova H, Raymond K, Vicogne D, Simon MEH, Pfundt R, Timal S, Beumers R, Biot C, Smeets R, Kersten M, Huijben K; CDG group , Ta Linders P, van den Bogaart G, van Hijum SAFT, Rodenburg R, van den Heuvel LP, van Spronsen F, Honzik T, Foulquier F, van Scherpenzeel M, Lefeber DJ
Citation:
Hum Mol Genet. 2018 Jun 5. doi: 10.1093/hmg/ddy213. [Epub ahead of print]
Epub:
Yes
Abstract:
Genomics methodologies have significantly improved elucidation of Mendelian disorders. The combination with high-throughput...
Link:
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddy213/5033379
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ashikov A, Abu Bakar N, Wen XY, Niemeijer M, Rodrigues Pinto Osorio G, Brand-Arzamendi K, Hasadsri L, Hansikova H, Raymond K, Vicogne D, Simon MEH, Pfundt R, Timal S, Beumers R, Biot C, Smeets R, Kersten M, Huijben K; CDG group , Ta Linders P, van den Bogaart G, van Hijum SAFT, Rodenburg R, van den Heuvel LP, van Spronsen F, Honzik T, Foulquier F, van Scherpenzeel M, Lefeber DJ. Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation. Hum Mol Genet. 2018 Jun 5. doi: 10.1093/hmg/ddy213. [Epub ahead of print].

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