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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
CFAP43 modulates ciliary beating in mouse and Xenopus
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Citation:
Dev Biol. 2019 Dec 27. pii: S0012-1606(19)30471-3. doi: 10.1016/j.ydbio.2019.12.010. [Epub ahead of print] Epub:
Yes Abstract:
Malfunctions of motile cilia cause a variety of developmental defects and diseases in humans and animal model organisms.... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Rachev E, Schuster-Gossler K, Fuhl F, Ott T, Tveriakhina L, Beckers A, Hegermann J, Boldt K, Mai M, Kremmer E, Ueffing M, Blum M, Gossler A. CFAP43 modulates ciliary beating in mouse and Xenopus. Dev Biol. 2019 Dec 27. pii: S0012-1606(19)30471-3. doi: 10.1016/j.ydbio.2019.12.010. [Epub ahead of print]. |
Differential Induction of SOCS Isoforms by Leishmania donovani Impairs Macrophage-T Cell Cross-Talk and Host Defense
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Citation:
J Immunol. 2019 Dec 27. pii: ji1900412. doi: 10.4049/jimmunol.1900412. [Epub ahead of print] Epub:
Yes Abstract:
Immune evasion strategies adopted by Leishmania donovani involve the exploitation of suppressor of cytokine signaling (SOCS)... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
BALB/c mice Citation Extract: Chandrakar P, Parmar N, Descoteaux A, Kar S. Differential Induction of SOCS Isoforms by Leishmania donovani Impairs Macrophage-T Cell Cross-Talk and Host Defense. J Immunol. 2019 Dec 27. pii: ji1900412. doi: 10.4049/jimmunol.1900412. [Epub ahead of print]. |
Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene
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Citation:
Mol Neurobiol. 2019 Dec 26. doi: 10.1007/s12035-019-01860-x. [Epub ahead of print] Epub:
Yes Abstract:
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gawel K, Turski WA, van der Ent W, Mathai BJ, Kirstein-Smardzewska KJ, Simonsen A, Esguerra CV. Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene. Mol Neurobiol. 2019 Dec 26. doi: 10.1007/s12035-019-01860-x. [Epub ahead of print]. |
A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo
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Citation:
Nat Biotechnol. 2020 Feb;38(2):169-175. doi: 10.1038/s41587-019-0357-y. Epub 2019 Dec 23. PMID: 31873216; PMCID: PMC7008088 Epub:
Not Epub Abstract:
Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell cultures, mice Citation Extract: Zhong G, Wang H, He W, Li Y, Mou H, Tickner ZJ, Tran MH, Ou T, Yin Y, Diao H, Farzan M. A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo. Nat Biotechnol. 2020 Feb;38(2):169-175. doi: 10.1038/s41587-019-0357-y. Epub 2019 Dec 23. PMID: 31873216; PMCID: PMC7008088. |
Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome
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Citation:
Matrix Biol. 2019 Dec 17. pii: S0945-053X(19)30400-7. doi: 10.1016/j.matbio.2019.12.002. [Epub ahead of print] Epub:
Yes Abstract:
β4GalT7 is a transmembrane Golgi enzyme, encoded by B4GALT7, that plays a pivotal role in the proteoglycan linker region... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Delbaere S, Van Damme T, Syx D, Symoens S, Coucke P, Willaert A, Malfait F. Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome. Matrix Biol. 2019 Dec 17. pii: S0945-053X(19)30400-7. doi: 10.1016/j.matbio.2019.12.002. [Epub ahead of print]. |
Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects
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Citation:
bioRxiv. 2019;[preprint] doi:10.1101/2019.12.19.880815 Epub:
Not Epub Abstract:
Background: Congenital hypothyroidism (CH) due to thyroid dysgenesis is a frequent congenital endocrine disorder for which the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Vandernoot I, Haerlingen B, Trubiroha A, Gillotay P, Janssens V, Opitz R, Costagliola S. Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects. bioRxiv. 2019;[preprint] doi:10.1101/2019.12.19.880815. |
Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease
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Citation:
Dis Model Mech. 2019;[Epub ahead of print] doi:10.1242/dmm.041426 Epub:
Yes Abstract:
Induction of endoplasmic reticulum (ER) stress is associated with diverse developmental and degenerative diseases. Modified ER... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Clark EM, Nonarath HJT, Bostrom JR, Link BA. Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease. Dis Model Mech. 2019;[Epub ahead of print] doi:10.1242/dmm.041426. |
Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology
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Citation:
J Cachexia Sarcopenia Musc. 2019;[Epub] doi:10.1002/jcsm.12506 Epub:
Yes Abstract:
Background: Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein.... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: van Westering TLE, Lomonosova Y, Coenen‐Stass AML, Betts CA, Bhomra A, Hulsker M, Clark LE, McClorey G, Aartsma‐Rus A, van Putten M, Wood MJA, Roberts TC. Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology. J Cachexia Sarcopenia Musc. 2019;[Epub] doi:10.1002/jcsm.12506. |
The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis
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Citation:
J Biol Chem. 2019;[Epub ahead of print] doi:10.1074/jbc.RA119.011751 Epub:
Yes Abstract:
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best characterized inflammasomes in humans and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li J-Y, Wang Y-Y, Shao T, Fan D-D, Lin A-F, Xiang L-X, Shao J-Z. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis. J Biol Chem. 2019;[Epub ahead of print] doi:10.1074/jbc.RA119.011751. |
Reassessing the contribution of the Na+/H+ exchanger Nhe3b to Na+ uptake in zebrafish (Danio rerio) using CRISPR/Cas9 gene editing
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Citation:
J Exp Biol. 2019;[Epub ahead of print] doi: 10.1242/jeb.215111 Epub:
Yes Abstract:
Freshwater fishes absorb Na+ from their dilute environment using ion-transporting cells. In larval zebrafish (Danio rerio), Na... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zimmer AM, Shir-Mohammadi K, Kwong RWM, Perry SF. Reassessing the contribution of the Na+/H+ exchanger Nhe3b to Na+ uptake in zebrafish (Danio rerio) using CRISPR/Cas9 gene editing. J Exp Biol. 2019;[Epub ahead of print] doi: 10.1242/jeb.215111. |