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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

A Conserved Role of the Unconventional Myosin 1d in Laterality Determination

Authors:
Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, LeBlanc-Straceski JM, Noselli S, Blum M
Citation:
Curr Biol. 2018;[Epub ahead of print] doi:10.1016/j.cub.2018.01.075
Epub:
Yes
Abstract:
Anatomical and functional asymmetries are widespread in the animal kingdom [1, 2]. In vertebrates, many visceral organs are...
Link:
www.cell.com/current-biology/fulltext/S0960-9822(18)30108-8
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, LeBlanc-Straceski JM, Noselli S, Blum M. A Conserved Role of the Unconventional Myosin 1d in Laterality Determination. Curr Biol. 2018;[Epub ahead of print] doi:10.1016/j.cub.2018.01.075.

Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus

Authors:
Gentsch GE, Spruce T, Monteiro RS, Owens NDL, Martin SR, Smith JC
Citation:
Dev Cell. 2018;[Epub ahead of print] doi:10.1016/j.devcel.2018.01.022
Epub:
Yes
Abstract:
Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD)...
Link:
http://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30057-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Gentsch GE, Spruce T, Monteiro RS, Owens NDL, Martin SR, Smith JC. Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus. Dev Cell. 2018;[Epub ahead of print] doi:10.1016/j.devcel.2018.01.022.

Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish

Authors:
Mukaigasa K, Tsujita T, Nguyen VT, Li L, Yagi H, Fuse Y, Nakajima-Takagi Y, Kato K, Yamamoto M, Kobayashi M
Citation:
PNAS. 2018;[Epub ahead of print] doi:10.1073/pnas.1714056115
Epub:
Yes
Abstract:
Nrf2 plays critical roles in animals’ defense against electrophiles and oxidative stress by orchestrating the induction of...
Link:
http://www.pnas.org/content/early/2018/02/21/1714056115
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mukaigasa K, Tsujita T, Nguyen VT, Li L, Yagi H, Fuse Y, Nakajima-Takagi Y, Kato K, Yamamoto M, Kobayashi M. Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish. PNAS. 2018;[Epub ahead of print] doi:10.1073/pnas.1714056115.

The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

Authors:
Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Nadendla EK, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M
Citation:
Sci Adv. 2018;4:eaao1261 doi:10.1126/sciadv.aao1261
Epub:
Not Epub
Abstract:
Retinoic acid (RA) is an important intercellular signaling molecule in vertebrate development, with a well-established role in...
Link:
http://advances.sciencemag.org/content/4/2/eaao1261
Delivery Method:
microinjection
Organism or Cell Type:
Platynereis dumerilii (annelid)
Citation Extract:
Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Nadendla EK, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M. The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation. Sci Adv. 2018;4:eaao1261 doi:10.1126/sciadv.aao1261.

Repurposing Dantrolene for Long-term Combination Therapy to Potentiate Antisense-Mediated DMD Exon-Skipping in the mdx mouse

Authors:
Wang DW, Mokhonova EI, Genevieve C. Kendall GC, Becerra D, Naeini YB, Cantor RM, Spencer MJ, Nelson SF, Miceli MC
Citation:
Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.002
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, essential to muscle health....
Link:
https://www.sciencedirect.com/science/article/pii/S2162253118300167
Delivery Method:
retroorbital injection
Organism or Cell Type:
mice mdx
Citation Extract:
Wang DW, Mokhonova EI, Genevieve C. Kendall GC, Becerra D, Naeini YB, Cantor RM, Spencer MJ, Nelson SF, Miceli MC. Repurposing Dantrolene for Long-term Combination Therapy to Potentiate Antisense-Mediated DMD Exon-Skipping in the mdx mouse. Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.002.

A dystrophic Duchenne mouse model for testing human antisense oligonucleotides

Authors:
Veltrop M, van Vliet L, Hulsker M, Claassens J, Brouwers C, Breukel C, van der Kaa J, Linssen MM, den Dunnen JT, Verbeek S, Aartsma-Rus A, van Putten M
Citation:
PLoS ONE. 2018;13(2):e0193289. doi:10.1371/journal.pone.0193289
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease generally caused by reading frame disrupting mutations in...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193289
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
del52hDMD/mdx mouse
Citation Extract:
Veltrop M, van Vliet L, Hulsker M, Claassens J, Brouwers C, Breukel C, van der Kaa J, Linssen MM, den Dunnen JT, Verbeek S, Aartsma-Rus A, van Putten M. A dystrophic Duchenne mouse model for testing human antisense oligonucleotides. PLoS ONE. 2018;13(2):e0193289. doi:10.1371/journal.pone.0193289.

Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery in vitro and in mdx Mice

Authors:
Wang M, Wu B, Shah SN, Lu P, Lu Q
Citation:
Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.004
Epub:
Yes
Abstract:
Antisense oligonucleotide (AON) therapy for Duchenne muscular dystrophy has drawn great attention in preclinical and clinical...
Link:
https://www.sciencedirect.com/science/article/pii/S2162253118300180
Delivery Method:
Endo-Porter or Saponin in culture, injection in mice
Organism or Cell Type:
cell culture: C2C12E50, C2C12E23; mice, mdx
Citation Extract:
Wang M, Wu B, Shah SN, Lu P, Lu Q. Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery in vitro and in mdx Mice. Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.004.

Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates

Authors:
Kirillova A, Genikhovich G, Pukhlyakova E, Demilly A, Kraus Y, Technau U
Citation:
Proc Natl Acad Sci U S A. 2018 Feb 9. pii: 201711516. doi: 10.1073/pnas.1711516115. [Epub ahead of print]
Epub:
Yes
Abstract:
Robust morphogenetic events are pivotal for animal embryogenesis. However, comparison of the modes of development of different...
Link:
http://www.pnas.org/content/115/8/1813
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Kirillova A, Genikhovich G, Pukhlyakova E, Demilly A, Kraus Y, Technau U. Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates. Proc Natl Acad Sci U S A. 2018 Feb 9. pii: 201711516. doi: 10.1073/pnas.1711516115. [Epub ahead of print].

Antisense inhibitors retain activity in pulmonary models of Burkholderia infection

Authors:
Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller B, Greenberg D
Citation:
ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print]
Epub:
Yes
Abstract:
The Burkholderia cepacia complex is a group of gram-negative bacteria that are opportunistic pathogens in immunocompromised...
Link:
https://pubs.acs.org/doi/10.1021/acsinfecdis.7b00235
Delivery Method:
peptide-linked
Organism or Cell Type:
Burkholderia cepacia, Pseudomonas
Citation Extract:
Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller B, Greenberg D. Antisense inhibitors retain activity in pulmonary models of Burkholderia infection. ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print].

Amplification-free detection of DNA in a paper-based microfluidic device using electroosmotically balanced isotachophoresis

Authors:
Rosenfeld T, Bercovici M
Citation:
Lab Chip. 2018 Feb 20. doi: 10.1039/c7lc01250k. [Epub ahead of print]
Epub:
Not Epub
Abstract:
We present a novel microfluidic paper-based analytical device (μPAD) which utilizes the native high electroosmotic flow (EOF)...
Link:
http://pubs.rsc.org/en/content/articlelanding/2018/lc/c7lc01250k#!divAbstract
Citation Extract:
Rosenfeld T, Bercovici M. Amplification-free detection of DNA in a paper-based microfluidic device using electroosmotically balanced isotachophoresis. Lab Chip. 2018 Feb 20. doi: 10.1039/c7lc01250k. [Epub ahead of print].

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