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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Pseudoexon exclusion by antisense therapy in 6-pyruvoyl-tetrahydropterin synthase deficiency

Authors:
Brasil S, Viecelli HM, Meili D, Rassi A, Desviat LR, Pérez B, Ugarte M, Thöny B
Citation:
Hum Mutat. 2011 May 3. doi: 10.1002/humu.21529. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Antisense oligonucleotide therapy to modulate splicing mutations in inherited diseases is emerging as a treatment option also...
Organism or Cell Type:
cell culture: human primary dermal fibroblasts
Citation Extract:
Brasil S, Viecelli HM, Meili D, Rassi A, Desviat LR, Pérez B, Ugarte M, Thöny B. Pseudoexon exclusion by antisense therapy in 6-pyruvoyl-tetrahydropterin synthase deficiency. Hum Mutat. 2011 May 3. doi: 10.1002/humu.21529. [Epub ahead of print].

Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein

Authors:
Calarco JA, Superina S, O'Hanlon D, Gabut M, Raj B, Pan Q, Skalska U, Clarke L, Gelinas D, van der Kooy D, Zhen M, Ciruna B, Blencowe BJ
Citation:
Cell. 2009 Sep 4;138(5):898-910
Epub:
Not Epub
Abstract:
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Calarco JA, Superina S, O'Hanlon D, Gabut M, Raj B, Pan Q, Skalska U, Clarke L, Gelinas D, van der Kooy D, Zhen M, Ciruna B, Blencowe BJ. Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell. 2009 Sep 4;138(5):898-910.

Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase

Authors:
Burns DM, Ying W, Kauppinen TM, Zhu K, Swanson RA
Citation:
PLoS ONE. 2009;4(3):e4896. Epub 2009 Mar 25
Epub:
Not Epub
Abstract:
BACKGROUND: The formation of ADP-ribose polymers on target proteins by poly(ADP-ribose) polymerases serves a variety of cell...
Delivery Method:
Special Delivery
Organism or Cell Type:
cell culture: mouse astrocytes
Citation Extract:
Burns DM, Ying W, Kauppinen TM, Zhu K, Swanson RA. Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. PLoS ONE. 2009;4(3):e4896. Epub 2009 Mar 25.

Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor

Authors:
Brugmann SA, Pandur PD, Kenyon KL, Pignoni F, Moody SA
Citation:
Development. 2004 Dec;131(23):5871-81. Epub 2004 Nov 3
Epub:
Not Epub
Abstract:
Cranial placodes, which give rise to sensory organs in the vertebrate head, are important embryonic structures whose...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Brugmann SA, Pandur PD, Kenyon KL, Pignoni F, Moody SA. Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development. 2004 Dec;131(23):5871-81. Epub 2004 Nov 3.

Slit1a Inhibits Retinal Ganglion Cell Arborization and Synaptogenesis via Robo2-Dependent and -Independent Pathways

Authors:
Campbell DS, Stringham SA, Timm A, Xiao T, Law MY, Baier H, Nonet ML, Chien CB
Citation:
Neuron. 2007 Jul 19;55(2):231-245
Epub:
Not Epub
Abstract:
Upon arriving at their targets, developing axons cease pathfinding and begin instead to arborize and form synapses. To test...
Citation Extract:
Campbell DS, Stringham SA, Timm A, Xiao T, Law MY, Baier H, Nonet ML, Chien CB. Slit1a Inhibits Retinal Ganglion Cell Arborization and Synaptogenesis via Robo2-Dependent and -Independent Pathways. Neuron. 2007 Jul 19;55(2):231-245.

Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells

Authors:
Bulut G, Hong SH, Chen K, Beauchamp EM, Rahim S, Kosturko GW, Glasgow E, Dakshanamurthy S, Lee HS, Daar I, Toretsky JA, Khanna C, Uren A
Citation:
Oncogene. 2012 Jan 19;31(3):269-81. doi: 10.1038/onc.2011.245. Epub 2011 Jun 27
Epub:
Not Epub
Abstract:
Ezrin is a multifunctional protein that connects the actin cytoskeleton to the extracellular matrix through transmembrane...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bulut G, Hong SH, Chen K, Beauchamp EM, Rahim S, Kosturko GW, Glasgow E, Dakshanamurthy S, Lee HS, Daar I, Toretsky JA, Khanna C, Uren A. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-81. doi: 10.1038/onc.2011.245. Epub 2011 Jun 27.

STAC3 is required for myotube formation and myogenic differentiation in vertebrate skeletal muscle

Authors:
Bower NI, Garcia de la Serrana D, Cole NJ, Hollway GE, Lee HT, Assinder S, Johnston IA
Citation:
J Biol Chem. 2012 Oct 17. [Epub ahead of print]
Epub:
Not Epub
Abstract:
STAC3 was identified as a nutritionally regulated gene from an Atlantic salmon subtractive hybridisation library with highest...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bower NI, Garcia de la Serrana D, Cole NJ, Hollway GE, Lee HT, Assinder S, Johnston IA. STAC3 is required for myotube formation and myogenic differentiation in vertebrate skeletal muscle. J Biol Chem. 2012 Oct 17. [Epub ahead of print].

T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish

Authors:
Bruce AE, Howley C, Dixon Fox M, Ho RK
Citation:
Dev Dyn. 2005 May;233(1):105-14.
Epub:
Not Epub
Abstract:
The T-box gene eomesodermin (eomes) has been implicated in mesoderm specification and patterning in both zebrafish and frog....
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bruce AE, Howley C, Dixon Fox M, Ho RK. T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish. Dev Dyn. 2005 May;233(1):105-14..

T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.

Authors:
Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S.
Citation:
Development. 2005 May;132(10):2475-87. Epub 2005 Apr 20.
Epub:
Not Epub
Abstract:
Mutations in T-box genes are the cause of several congenital diseases and are implicated in cancer. Tbx20-null mice exhibit...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S.. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.. Development. 2005 May;132(10):2475-87. Epub 2005 Apr 20..

Targeted 'knockdown' of channel expression in vivo with an antisense morpholino oligonucleotide

Authors:
Brent L, Drapeau P
Citation:
Neuroscience 2002 Oct 1;114(2):275
Epub:
Not Epub
Abstract:
We have examined whether antisense morpholino oligonucleotides (morpholinos) can be used as a tool to suppress or \"...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brent L, Drapeau P. Targeted 'knockdown' of channel expression in vivo with an antisense morpholino oligonucleotide. Neuroscience 2002 Oct 1;114(2):275.

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