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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation

Authors:
Yan MS, Turgeon PJ, Man HSJ, Dubinsky MK, Ho Jr JD, El-Rass S, Wang Y-D, Wen X-Y, Marsden PA
Citation:
J Biol Chem. 2018;[Epub ahead of print] doi:10.1074/jbc.RA117.001383
Epub:
Yes
Abstract:
Although the functional role of chromatin marks at promoters in mediating cell-restricted gene expression has been well...
Link:
http://www.jbc.org/content/early/2018/02/06/jbc.RA117.001383.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yan MS, Turgeon PJ, Man HSJ, Dubinsky MK, Ho Jr JD, El-Rass S, Wang Y-D, Wen X-Y, Marsden PA. Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation. J Biol Chem. 2018;[Epub ahead of print] doi:10.1074/jbc.RA117.001383.

Deficiency of a novel gene, Yulink, predisposes to heart failure and ventricular arrhythmia

Authors:
Tsai CT, Kuo MW, Lin JL, Yu AL, Yu J
Citation:
FASEB J. 2018 Jan 11:fj201700932RR. doi: 10.1096/fj.201700932RR. [Epub ahead of print]
Epub:
Yes
Abstract:
Heart failure is a major cardiovascular disease and is associated with significant morbidity and mortality. Sudden cardiac...
Link:
http://www.fasebj.org/doi/abs/10.1096/fj.201700932RR
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tsai CT, Kuo MW, Lin JL, Yu AL, Yu J. Deficiency of a novel gene, Yulink, predisposes to heart failure and ventricular arrhythmia. FASEB J. 2018 Jan 11:fj201700932RR. doi: 10.1096/fj.201700932RR. [Epub ahead of print].

Modifier variant of METTL13 suppresses human GAB1-associated profound deafness

Authors:
Yousaf R, Ahmed ZM, Giese AP, Morell RJ, Lagziel A, Dabdoub A, Wilcox ER, Riazuddin S, Friedman TB, Riazuddin S
Citation:
J Clin Invest. 2018 Feb 6. pii: 97350. doi: 10.1172/JCI97350. [Epub ahead of print]
Epub:
Yes
Abstract:
A modifier variant can abrogate risk of a monogenic disorder. DFNM1 is a locus on chromosome 1 encoding a dominant suppressor...
Link:
https://www.jci.org/articles/view/97350
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yousaf R, Ahmed ZM, Giese AP, Morell RJ, Lagziel A, Dabdoub A, Wilcox ER, Riazuddin S, Friedman TB, Riazuddin S. Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. J Clin Invest. 2018 Feb 6. pii: 97350. doi: 10.1172/JCI97350. [Epub ahead of print].

Germ cell depletion in zebrafish leads to incomplete masculinization of the brain

Authors:
Pradhan A, Olsson PE
Citation:
Gen Comp Endocrinol. 2018 Feb 3. pii: S0016-6480(17)30670-6. doi: 10.1016/j.ygcen.2018.02.001. [Epub ahead of print]
Epub:
Yes
Abstract:
Zebrafish sex differentiation is under the control of multiple genes, but also relies on germ cell number for gonadal...
Link:
https://www.sciencedirect.com/science/article/pii/S0016648017306706
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pradhan A, Olsson PE. Germ cell depletion in zebrafish leads to incomplete masculinization of the brain. Gen Comp Endocrinol. 2018 Feb 3. pii: S0016-6480(17)30670-6. doi: 10.1016/j.ygcen.2018.02.001. [Epub ahead of print].

Developmental evolution of the forebrain in cavefish, from natural variations in neuropeptides to behavior

Authors:
Alié A, Devos L, Torres-Paz J, Prunier L, Boulet F, Blin M, Elipot Y, Retaux S
Citation:
eLife. 2018:e32808. doi:10.7554/eLife.32808
Epub:
Not Epub
Abstract:
The fish Astyanax mexicanus comes in two forms: the normal surface-dwelling and the blind depigmented cave-adapted morphs....
Link:
https://elifesciences.org/articles/32808
Delivery Method:
microinjection
Organism or Cell Type:
Astyanax mexicanus (fish, with cavefish form)
Citation Extract:
Alié A, Devos L, Torres-Paz J, Prunier L, Boulet F, Blin M, Elipot Y, Retaux S. Developmental evolution of the forebrain in cavefish, from natural variations in neuropeptides to behavior. eLife. 2018:e32808. doi:10.7554/eLife.32808.

LSD1 interacts with cMYB to demethylate repressive histone marks and maintains inner ear progenitor identity

Authors:
Ahmed M, Streit A
Citation:
Development. 2018;[Epub ahead of print] doi:10.1242/dev.160325
Epub:
Yes
Abstract:
During development, multipotent progenitor cells must maintain their identity while retaining the competence to respond to new...
Link:
http://dev.biologists.org/content/early/2018/02/03/dev.160325
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Ahmed M, Streit A. LSD1 interacts with cMYB to demethylate repressive histone marks and maintains inner ear progenitor identity. Development. 2018;[Epub ahead of print] doi:10.1242/dev.160325.

Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue

Authors:
Hatte G, Prigent C, Tassan JP
Citation:
J Cell Sci. 2017 Dec 15. pii: jcs.208736. doi: 10.1242/jcs.208736. [Epub ahead of print]
Epub:
Yes
Abstract:
Epithelia are layers of polarised cells tightly bound to each other by adhesive contacts. Epithelia act as barriers between an...
Link:
http://jcs.biologists.org/content/131/3/jcs208736
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Hatte G, Prigent C, Tassan JP. Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue. J Cell Sci. 2017 Dec 15. pii: jcs.208736. doi: 10.1242/jcs.208736. [Epub ahead of print].

Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP

Authors:
Chiu AC, Suzuki HI, Wu X, Mahat DB, Kriz AJ, Sharp PA
Citation:
Molec Cell. 2018;[Epub ahead of print] doi:10.1016/j.molcel.2018.01.006
Epub:
Not Epub
Abstract:
Regulation of RNA polymerase II (Pol II) elongation is a critical step in gene regulation. Here, we report that U1 snRNP...
Link:
http://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30006-6
Citation Extract:
Chiu AC, Suzuki HI, Wu X, Mahat DB, Kriz AJ, Sharp PA. Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Molec Cell. 2018;[Epub ahead of print] doi:10.1016/j.molcel.2018.01.006.

Differentiation-dependent antiviral capacities of amphibian (Xenopus laevis) macrophages

Authors:
Yaparla A, Popovic M, Grayfer L
Citation:
J Biol Chem. 2018 Feb 2;293(5):1736-1744. doi: 10.1074/jbc.M117.794065. Epub 2017 Dec 19. PMID: 29259133; PMCID: PMC5798303
Epub:
Yes
Abstract:
Infections by ranaviruses such as Frog virus 3 (Fv3) are significantly contributing to the worldwide amphibian population...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC5798303/
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
cell culture: Xenopus laevis kidney (A6) cell line
Citation Extract:
Yaparla A, Popovic M, Grayfer L. Differentiation-dependent antiviral capacities of amphibian (Xenopus laevis) macrophages. J Biol Chem. 2018 Feb 2;293(5):1736-1744. doi: 10.1074/jbc.M117.794065. Epub 2017 Dec 19. PMID: 29259133; PMCID: PMC5798303.

A novel gene's role in an ancient mechanism: secreted Frizzled-related protein 1 is a critical component in the anterior-posterior Wnt signaling network that governs the establishment of the anterior neuroectoderm in sea urchin embryos

Authors:
Khadka A, Martínez-Bartolomé M, Burr SD, Range RC
Citation:
Evodevo. 2018 Jan 22;9:1. doi: 10.1186/s13227-017-0089-3. eCollection 2018
Epub:
Not Epub
Abstract:
The anterior neuroectoderm (ANE) in many deuterostome embryos (echinoderms, hemichordates, urochordates, cephalochordates, and...
Link:
https://evodevojournal.biomedcentral.com/articles/10.1186/s13227-017-0089-3
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Khadka A, Martínez-Bartolomé M, Burr SD, Range RC. A novel gene's role in an ancient mechanism: secreted Frizzled-related protein 1 is a critical component in the anterior-posterior Wnt signaling network that governs the establishment of the anterior neuroectoderm in sea urchin embryos. Evodevo. 2018 Jan 22;9:1. doi: 10.1186/s13227-017-0089-3. eCollection 2018.

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