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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development

Authors:
Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS-K, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP
Citation:
PNAS USA. 2018;[Epub ahead of print] doi:10.1073/pnas.1811624115
Epub:
Yes
Abstract:
Codevelopment of the lungs and heart underlies key evolutionary innovations in the transition to terrestrial life. Cardiac...
Link:
http://www.pnas.org/content/early/2018/10/22/1811624115
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS-K, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP. Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. PNAS USA. 2018;[Epub ahead of print] doi:10.1073/pnas.1811624115.

K120R mutation inactivates p53 by creating an aberrant splice site leading to nonsense-mediated mRNA decay

Authors:
Lee SY, Park JH, Jeong S, Kim BY, Kang YK, Xu Y, Chung SK
Citation:
Oncogene. 2018 Oct 22. doi: 10.1038/s41388-018-0542-3. [Epub ahead of print]
Epub:
Yes
Abstract:
The point mutation that substitutes lysine with arginine at position 120 of human p53 has been characterized as a missense...
Link:
https://www.nature.com/articles/s41388-018-0542-3
Organism or Cell Type:
cell culture: human engineered iPSC line
Citation Extract:
Lee SY, Park JH, Jeong S, Kim BY, Kang YK, Xu Y, Chung SK. K120R mutation inactivates p53 by creating an aberrant splice site leading to nonsense-mediated mRNA decay. Oncogene. 2018 Oct 22. doi: 10.1038/s41388-018-0542-3. [Epub ahead of print].

Electroporation and in vitro culture of early rabbit embryos

Authors:
Betters E, Charney RM, García-Castro MI
Citation:
Dev Biol. 2018;[Epub ahead of print] doi:10.1016/j.ydbio.2018.06.012
Epub:
Yes
Abstract:
The phenomenal migratory and differentiation capacity of neural crest cells has been well established across model organisms....
Link:
https://www.sciencedirect.com/science/article/pii/S0012160618301477
Delivery Method:
electroporation
Organism or Cell Type:
Oryctolagus cuniculus (rabbit)
Citation Extract:
Betters E, Charney RM, García-Castro MI. Electroporation and in vitro culture of early rabbit embryos. Dev Biol. 2018;[Epub ahead of print] doi:10.1016/j.ydbio.2018.06.012.

Efficacy of multi-exon skipping treatment in Duchenne muscular dystrophy dog model neonates

Authors:
Lim KRQ, Echigoya Y, Nagata T, Kuraoka M, Kobayashi M, Aoki Y, Partridge T, Maruyama R, Takeda S, Yokota T
Citation:
Molec Therapy. 2018;[Epub ahead of print] doi:10.1016/j.ymthe.2018.10.011
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, which codes for dystrophin. Because the progressive and...
Link:
https://www.sciencedirect.com/science/article/pii/S1525001618305008
Delivery Method:
i.v. infusion
Organism or Cell Type:
Canis familiaris (dog)
Citation Extract:
Lim KRQ, Echigoya Y, Nagata T, Kuraoka M, Kobayashi M, Aoki Y, Partridge T, Maruyama R, Takeda S, Yokota T. Efficacy of multi-exon skipping treatment in Duchenne muscular dystrophy dog model neonates. Molec Therapy. 2018;[Epub ahead of print] doi:10.1016/j.ymthe.2018.10.011.

Interaction of modified oligonucleotides with nuclear proteins, formation of novel nuclear structures and sequence-independent effects on RNA processing

Authors:
Flynn LL, Li R, Aung-Htut MT, Pitout IL, Cooper J, Hubbard A, Griffiths L, Bond C, Wilton SD, Fox AH, Fletcher S
Citation:
bioRxiv. 2018:446773[Preprint] doi:10.1101/446773
Epub:
Not Epub
Abstract:
Oligonucleotides and nucleic acid analogues that alter gene expression are showing therapeutic promise for selected human...
Link:
https://www.biorxiv.org/content/early/2018/10/18/446773
Organism or Cell Type:
cell culture
Citation Extract:
Flynn LL, Li R, Aung-Htut MT, Pitout IL, Cooper J, Hubbard A, Griffiths L, Bond C, Wilton SD, Fox AH, Fletcher S. Interaction of modified oligonucleotides with nuclear proteins, formation of novel nuclear structures and sequence-independent effects on RNA processing. bioRxiv. 2018:446773[Preprint] doi:10.1101/446773 .

NADPH-Oxidase-derived reactive oxygen species are required for cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly

Authors:
Mendieta-Serrano MA, Mendez-Cruz FJ, Antúnez-Mojica M, Schnabel D, Alvarez L, Cárdenas L, Lomelí H, Ruiz-Santiesteban JA, Salas-Vidal E
Citation:
Free Radic Biol Med. 2018 Oct 17. pii: S0891-5849(18)32192-0. doi: 10.1016/j.freeradbiomed.2018.10.416. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Cell movements are essential for morphogenesis during animal development. Epiboly is the first morphogenetic process in...
Link:
https://www.sciencedirect.com/science/article/pii/S0891584918321920
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mendieta-Serrano MA, Mendez-Cruz FJ, Antúnez-Mojica M, Schnabel D, Alvarez L, Cárdenas L, Lomelí H, Ruiz-Santiesteban JA, Salas-Vidal E. NADPH-Oxidase-derived reactive oxygen species are required for cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly. Free Radic Biol Med. 2018 Oct 17. pii: S0891-5849(18)32192-0. doi: 10.1016/j.freeradbiomed.2018.10.416. [Epub ahead of print].

Basal epithelial tissue folding is mediated by differential regulation of microtubules

Authors:
Visetsouk MR, Falat EJ, Garde RJ, Wendlick JL, Gutzman JH
Citation:
Development. 2018 Oct 17. pii: dev.167031. doi: 10.1242/dev.167031. [Epub ahead of print]
Epub:
Yes
Abstract:
The folding of epithelial tissues is critical for development of three-dimensional structure and function. Understanding this...
Link:
http://dev.biologists.org/content/early/2018/10/10/dev.167031
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Visetsouk MR, Falat EJ, Garde RJ, Wendlick JL, Gutzman JH. Basal epithelial tissue folding is mediated by differential regulation of microtubules. Development. 2018 Oct 17. pii: dev.167031. doi: 10.1242/dev.167031. [Epub ahead of print].

Resting cells rely on the DNA helicase component MCM2 to build cilia

Authors:
Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M
Citation:
Nucleic Acids Res. 2018 Oct 17. doi: 10.1093/nar/gky945. [Epub ahead of print]
Epub:
Yes
Abstract:
Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand....
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky945/5133663
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M. Resting cells rely on the DNA helicase component MCM2 to build cilia. Nucleic Acids Res. 2018 Oct 17. doi: 10.1093/nar/gky945. [Epub ahead of print].

EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish

Authors:
Barrodia P, Patra C, Swain RK
Citation:
Cell & Biosci. 2018;8:53. doi:10.1186/s13578-018-0253-z
Epub:
Not Epub
Abstract:
Background: The blood filtering organ in zebrafish embryos is the pronephros, which consists of two functional nephrons....
Link:
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-018-0253-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Barrodia P, Patra C, Swain RK. EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish. Cell & Biosci. 2018;8:53. doi:10.1186/s13578-018-0253-z.

Identification of novel antisense-mediated exon skipping targets in DYSF for therapeutic treatment of dysferlinopathy

Authors:
Lee JJA, Maruyama R, Duddy W, Sakurai H, Yokota T
Citation:
Molec Ther Nucleic Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.10.004
Epub:
Yes
Abstract:
Dysferlinopathy is a progressive myopathy caused by mutations in the dysferlin (DYSF) gene. Dysferlin protein plays a major...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30275-0
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human fibroblast
Citation Extract:
Lee JJA, Maruyama R, Duddy W, Sakurai H, Yokota T. Identification of novel antisense-mediated exon skipping targets in DYSF for therapeutic treatment of dysferlinopathy. Molec Ther Nucleic Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.10.004.

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