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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technology

Authors:
Chen X, Liu M, Lou H, Lu Y, Zhou M-T, Ou R, Xu Y, Kai-Fu Tang K-F
Citation:
Genome Bio. 2019;20:19. doi:10.1186/s13059-019-1624-4
Epub:
Not Epub
Abstract:
Trim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins...
Link:
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1624-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen X, Liu M, Lou H, Lu Y, Zhou M-T, Ou R, Xu Y, Kai-Fu Tang K-F. Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technology. Genome Bio. 2019;20:19. doi:10.1186/s13059-019-1624-4.

Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance

Authors:
Bustamante-Marin XM, Yin WN, Sears PR, Werner ME, Brotslaw EJ, Mitchell BJ, Jania CM, Zeman KL, Rogers TD, Herring LE, Refabért L, Thomas L, Amselem S, Escudier E, Legendre M, Grubb BR, Knowles MR, Zariwala MA, Ostrowski LE
Citation:
Am J Hum Genet. 2019 Jan 18. pii: S0002-9297(18)30460-9. doi: 10.1016/j.ajhg.2018.12.009. [Epub ahead of print]
Epub:
Yes
Abstract:
Primary ciliary dyskinesia (PCD) is a genetic disorder in which impaired ciliary function leads to chronic airway disease....
Link:
https://www.cell.com/ajhg/pdfExtended/S0002-9297(18)30460-9
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bustamante-Marin XM, Yin WN, Sears PR, Werner ME, Brotslaw EJ, Mitchell BJ, Jania CM, Zeman KL, Rogers TD, Herring LE, Refabért L, Thomas L, Amselem S, Escudier E, Legendre M, Grubb BR, Knowles MR, Zariwala MA, Ostrowski LE. Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance. Am J Hum Genet. 2019 Jan 18. pii: S0002-9297(18)30460-9. doi: 10.1016/j.ajhg.2018.12.009. [Epub ahead of print].

An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy

Authors:
Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S
Citation:
Nat Cell Biol. 2019 Jan 21. doi: 10.1038/s41556-018-0260-7. [Epub ahead of print]
Epub:
Yes
Abstract:
Drug-based strategies to overcome tumour resistance to radiotherapy (R-RT) remain limited by the single-agent toxicity of...
Link:
https://www.nature.com/articles/s41556-018-0260-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nat Cell Biol. 2019 Jan 21. doi: 10.1038/s41556-018-0260-7. [Epub ahead of print].

The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation

Authors:
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ, Pitzalis C, Wilson AG
Citation:
J Immunol. 2019 Jan 18. pii: ji1801155. doi: 10.4049/jimmunol.1801155. [Epub ahead of print]
Epub:
Yes
Abstract:
Genetic variants in C5orf30 have been associated with development of the autoimmune conditions primary biliary cirrhosis and...
Link:
http://www.jimmunol.org/content/early/2019/01/17/jimmunol.1801155
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ, Pitzalis C, Wilson AG. The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation. J Immunol. 2019 Jan 18. pii: ji1801155. doi: 10.4049/jimmunol.1801155. [Epub ahead of print].

N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway

Authors:
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, Groth J, Foo WC, Liang C, Hu H, Huang J
Citation:
Mol Cancer. 2019 Jan 18;18(1):11. doi: 10.1186/s12943-019-0941-2
Epub:
Not Epub
Abstract:
BACKGROUND: MYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc...
Link:
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-019-0941-2
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: LNCaP
Citation Extract:
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, Groth J, Foo WC, Liang C, Hu H, Huang J. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. Mol Cancer. 2019 Jan 18;18(1):11. doi: 10.1186/s12943-019-0941-2.

Krüppel-like factor gene function in the ctenophore Mnemiopsis suggests an ancient role in promoting cell proliferation in metazoan stem cell niches

Authors:
Presnell JS, Browne WE
Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/527002
Epub:
Not Epub
Abstract:
All animals possess pluripotent stem cells that during an organism's lifespan give rise to differentiated cell types and...
Link:
https://www.biorxiv.org/content/early/2019/01/21/527002
Delivery Method:
microinjection
Organism or Cell Type:
Mnemiopsis leidyi (ctenophore)
Citation Extract:
Presnell JS, Browne WE. Krüppel-like factor gene function in the ctenophore Mnemiopsis suggests an ancient role in promoting cell proliferation in metazoan stem cell niches. bioRxiv. 2018;[Preprint] doi:10.1101/527002 .

Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity

Authors:
Wang H, Paulson EE, Ma L, Ross PJ, Schultz RM
Citation:
Epigenetics. 2019 Jan 19. doi: 10.1080/15592294.2019.1570771. [Epub ahead of print]
Epub:
Yes
Abstract:
Enhancer of zeste homolog 2 (EZH2), a component of the PRC2 complex, trimethylates H3K27, a transcriptionally repressive...
Link:
https://www.tandfonline.com/doi/abs/10.1080/15592294.2019.1570771
Organism or Cell Type:
mouse eggs & diploidized parthenotes
Citation Extract:
Wang H, Paulson EE, Ma L, Ross PJ, Schultz RM. Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity. Epigenetics. 2019 Jan 19. doi: 10.1080/15592294.2019.1570771. [Epub ahead of print].

A dual function of FGF signaling in Xenopus left-right axis formation

Authors:
Schneider I, Kreis J, Schweickert A, Blum M, Vick P
Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/469791
Epub:
Not Epub
Abstract:
Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-sided activation of Nodal...
Link:
https://www.biorxiv.org/content/early/2018/11/13/469791
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schneider I, Kreis J, Schweickert A, Blum M, Vick P. A dual function of FGF signaling in Xenopus left-right axis formation. bioRxiv. 2018;[Preprint] doi:10.1101/469791.

De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism

Authors:
Zawerton A, Yao B, Yeager JP, Pippucci T, Haseeb A, Smith JD, Wischmann L, Kühl SJ, Dean JCS, Pilz DT, Holder SE, Deciphering Developmental Disorders Study, University of Washington Center for Mendelian Genomics, McNeill A, Graziano C, Lefebvre V
Citation:
Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2018.12.014
Epub:
Yes
Abstract:
SOX4, together with SOX11 and SOX12, forms group C of SRY-related (SOX) transcription factors. They play key roles, often in...
Link:
https://www.cell.com/ajhg/pdfExtended/S0002-9297(18)30467-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Zawerton A, Yao B, Yeager JP, Pippucci T, Haseeb A, Smith JD, Wischmann L, Kühl SJ, Dean JCS, Pilz DT, Holder SE, Deciphering Developmental Disorders Study, University of Washington Center for Mendelian Genomics, McNeill A, Graziano C, Lefebvre V. De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism. Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2018.12.014.

TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis

Authors:
Lan Y, Pan H, Li C, Banks KM, Sam J, Ding B, Elemento O, Goll MG, Evans T
Citation:
Cell Rep. 2019;26:720-32. doi:10.1016/j.celrep.2018.12.076
Epub:
Not Epub
Abstract:
Ten-eleven translocation (Tet) enzymes (Tet1/2/3) mediate 5-methylcytosine (5mC) hydroxylation, which can facilitate DNA...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)32021-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lan Y, Pan H, Li C, Banks KM, Sam J, Ding B, Elemento O, Goll MG, Evans T. TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Cell Rep. 2019;26:720-32. doi:10.1016/j.celrep.2018.12.076.

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